Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DDIT4
  • Mouse genes Ddit4
  • Rat genes Ddit4
  • Zfish genes ddit4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ddit4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	Ddit4	IDA		Mouse	PMID:18198340
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:P08195-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:P16284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:P40337-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:P57682	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:P58304	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:P61086	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:Q14145	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:Q3SYB3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:Q6P1K2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:Q96MN9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDIT4	IPI	UniProtKB:Q9Y483-4	Human	PMID:32814053
Cellular Component	GO:0005737	cytoplasm	DDIT4	IDA		Human	PMID:12453409
Cellular Component	GO:0005829	cytosol	DDIT4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Ddit4	IDA		Mouse	PMID:20176937
Biological Process	GO:0006915	apoptotic process	Ddit4	IDA		Rat	PMID:11884613|RGD:633979
Biological Process	GO:0007420	brain development	Ddit4	IMP		Rat	PMID:21368030|RGD:8554300
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Ddit4	IDA		Mouse	PMID:17556672
Biological Process	GO:0051607	defense response to virus	DDIT4	IDA		Human	PMID:21478870
Biological Process	GO:0009953	dorsal/ventral pattern formation	ddit4	IMP	ZFIN:ZDB-MRPHLNO-130225-7	Zfish	PMID:23300740
Biological Process	GO:0009953	dorsal/ventral pattern formation	ddit4	IMP	ZFIN:ZDB-MRPHLNO-130225-6	Zfish	PMID:23300740
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Ddit4	IMP		Mouse	MGI:MGI:5298149|PMID:21896779
Biological Process	GO:0045820	negative regulation of glycolytic process	Ddit4	IMP		Mouse	PMID:20176937
Biological Process	GO:1902532	negative regulation of intracellular signal transduction	Ddit4	IMP		Rat	PMID:19118169|RGD:8554415
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	Ddit4	IMP		Rat	PMID:19118169|RGD:8554415
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	Ddit4	IMP		Rat	PMID:19118169|RGD:8554415
Biological Process	GO:0032007	negative regulation of TOR signaling	DDIT4	IMP		Human	PMID:20166753
Biological Process	GO:0032007	negative regulation of TOR signaling	Ddit4	IMP		Mouse	PMID:18198340
Biological Process	GO:0032007	negative regulation of TOR signaling	Ddit4	IMP		Rat	PMID:21368030|RGD:8554300
Biological Process	GO:0030182	neuron differentiation	Ddit4	IMP		Rat	PMID:21368030|RGD:8554300
Biological Process	GO:0001764	neuron migration	Ddit4	IMP		Rat	PMID:21368030|RGD:8554300
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	Ddit4	IMP		Rat	PMID:21368030|RGD:8554300
Biological Process	GO:1901216	positive regulation of neuron death	Ddit4	IMP		Rat	PMID:19118169|RGD:8554415
Biological Process	GO:0032984	protein-containing complex disassembly	Ddit4	IMP		Mouse	PMID:18198340
Biological Process	GO:0072593	reactive oxygen species metabolic process	Ddit4	IMP		Mouse	PMID:20176937
Biological Process	GO:0001666	response to hypoxia	DDIT4	IDA		Human	PMID:20166753
Biological Process	GO:0001666	response to hypoxia	Ddit4	IMP		Mouse	PMID:18198340
Biological Process	GO:0001666	response to hypoxia	Ddit4	IDA		Rat	PMID:11884613|RGD:633979

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern