Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DDR2
  • Mouse genes Ddr2
  • Rat genes Ddr2
  • Zfish genes ddr2a,ddr2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ddr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	DDR2	IDA		Human	PMID:20004161
Molecular Function	GO:0005518	collagen binding	Ddr2	IDA		Mouse	PMID:16806867
Molecular Function	GO:0005518	collagen binding	Ddr2	IDA		Rat	PMID:12220173|RGD:727757
Molecular Function	GO:0005515	protein binding	DDR2	IPI	UniProtKB:P13942	Human	PMID:17703188
Molecular Function	GO:0005515	protein binding	DDR2	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	DDR2	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	DDR2	IPI	UniProtKB:P08238	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	DDR2	IPI	UniProtKB:Q08345	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	DDR2	IPI	UniProtKB:Q16288	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	DDR2	IPI	UniProtKB:Q16543	Human	PMID:35384245
Molecular Function	GO:0038062	protein tyrosine kinase collagen receptor activity	DDR2	IDA		Human	PMID:9659899
Molecular Function	GO:0038062	protein tyrosine kinase collagen receptor activity	Ddr2	IDA		Mouse	MGI:MGI:2158097|PMID:11723120
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	DDR2	IDA		Human	PMID:20004161
Cellular Component	GO:0015629	actin cytoskeleton	DDR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016324	apical plasma membrane	Ddr2	IDA		Rat	PMID:15218324|RGD:2303414
Cellular Component	GO:0005925	focal adhesion	DDR2	HDA		Human	PMID:21423176
Cellular Component	GO:0005886	plasma membrane	DDR2	IDA		Human	GO_REF:0000052
Biological Process	GO:0031214	biomineral tissue development	Ddr2	IMP		Mouse	MGI:MGI:5318020|PMID:19900459
Biological Process	GO:1904385	cellular response to angiotensin	Ddr2	IEP		Rat	PMID:26674152|RGD:11554781
Biological Process	GO:0071456	cellular response to hypoxia	Ddr2	IEP		Rat	PMID:18664364|RGD:150429768
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Ddr2	IEP		Rat	PMID:16087782|RGD:150429767
Biological Process	GO:0035988	chondrocyte proliferation	Ddr2	IMP		Mouse	MGI:MGI:2158837|PMID:11375938
Biological Process	GO:0030199	collagen fibril organization	Ddr2	IMP		Mouse	MGI:MGI:5318020|PMID:19900459
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	DDR2	IDA		Human	PMID:16186108
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	Ddr2	IDA		Mouse	MGI:MGI:2158097|PMID:11723120
Biological Process	GO:0003416	endochondral bone growth	Ddr2	IMP		Mouse	MGI:MGI:2158837|PMID:11375938
Biological Process	GO:0043066	negative regulation of apoptotic process	Ddr2	IMP		Rat	PMID:23409069|RGD:150517731
Biological Process	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	Ddr2	IMP		Rat	PMID:32412792|RGD:150429761
Biological Process	GO:0033673	negative regulation of kinase activity	Ddr2	IMP		Rat	PMID:19762078|RGD:150429972
Biological Process	GO:0060547	negative regulation of necrotic cell death	Ddr2	IMP		Rat	PMID:23409069|RGD:150517731
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	DDR2	IDA		Human	PMID:20004161
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ddr2	IMP	MGI:MGI:2388155	Mouse	PMID:11723120
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Ddr2	IDA		Rat	PMID:24938620|RGD:150429973
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	Ddr2	IMP		Rat	PMID:26674152|RGD:11554781
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	DDR2	IMP		Human	PMID:20564243
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Ddr2	IMP		Rat	PMID:26674152|RGD:11554781
Biological Process	GO:0090091	positive regulation of extracellular matrix disassembly	Ddr2	IMP		Mouse	MGI:MGI:2158097|PMID:11723120
Biological Process	GO:0010763	positive regulation of fibroblast migration	Ddr2	IMP		Mouse	MGI:MGI:2158097|PMID:11723120
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Ddr2	IMP		Mouse	MGI:MGI:2158097|PMID:11723120
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Ddr2	IMP		Mouse	MGI:MGI:2158837|PMID:11375938
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Ddr2	IMP		Rat	PMID:32412792|RGD:150429761
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	Ddr2	IMP		Rat	PMID:23409069|RGD:150517731
Biological Process	GO:1904899	positive regulation of hepatic stellate cell proliferation	Ddr2	IMP		Rat	PMID:23409069|RGD:150517731
Biological Process	GO:1901216	positive regulation of neuron death	Ddr2	IMP		Rat	PMID:28863860|RGD:150519888
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	DDR2	IMP		Human	PMID:20564243
Biological Process	GO:0045860	positive regulation of protein kinase activity	DDR2	IMP		Human	PMID:20564243
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	Ddr2	IMP		Rat	PMID:18664364|RGD:150429768
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Ddr2	IMP		Rat	PMID:16087782|RGD:150429767
Biological Process	GO:0090303	positive regulation of wound healing	Ddr2	IMP		Rat	PMID:26674152|RGD:11554781
Biological Process	GO:0046777	protein autophosphorylation	DDR2	IDA		Human	PMID:16186108
Biological Process	GO:0046777	protein autophosphorylation	Ddr2	IDA		Mouse	PMID:16806867
Biological Process	GO:0030500	regulation of bone mineralization	DDR2	IMP		Human	PMID:20564243
Biological Process	GO:0034103	regulation of tissue remodeling	DDR2	IMP		Human	PMID:30449416
Biological Process	GO:0035994	response to muscle stretch	Ddr2	IEP		Rat	PMID:16087782|RGD:150429767
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Ddr2	IDA		Mouse	PMID:11723120

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern