Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DDX11,DDX11L8,DDX12P
  • Mouse genes Ddx11
  • Rat genes Ddx11
  • Zfish genes ddx11
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ddx11

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043139	5'-3' DNA helicase activity	DDX11	IDA		Human	PMID:18499658
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	DDX11	IDA		Human	PMID:10648783
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	DDX11	IMP		Human	PMID:26089203
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	DDX11	IDA		Human	PMID:26503245
Molecular Function	GO:0008186	ATP-dependent activity, acting on RNA	DDX11	IDA		Human	PMID:27477908
Molecular Function	GO:0003682	chromatin binding	DDX11	IMP		Human	PMID:20124417
Molecular Function	GO:0003682	chromatin binding	DDX11	IMP		Human	PMID:26089203
Molecular Function	GO:0003682	chromatin binding	DDX11	IDA		Human	PMID:26503245
Molecular Function	GO:0003682	chromatin binding	DDX11	IMP		Human	PMID:27477908
Molecular Function	GO:0003677	DNA binding	DDX11	IDA		Human	PMID:26503245
Molecular Function	GO:0003678	DNA helicase activity	DDX11	IDA		Human	PMID:26503245
Molecular Function	GO:0003688	DNA replication origin binding	DDX11	IMP		Human	PMID:27477908
Molecular Function	GO:0003690	double-stranded DNA binding	DDX11	IDA		Human	PMID:9013641
Molecular Function	GO:0051880	G-quadruplex DNA binding	DDX11	IDA		Human	PMID:26503245
Molecular Function	GO:0004386	helicase activity	DDX11	IDA		Human	PMID:10648783
Molecular Function	GO:0004386	helicase activity	DDX11	IDA		Human	PMID:18499658
Molecular Function	GO:0005515	protein binding	DDX11L8	IPI	UniProtKB:P29991:PRO_0000308465	Human	PMID:21911577
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:O60216	Human	PMID:17105772
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:Q9UQE7	Human	PMID:17105772
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:P03122	Human	PMID:17189189
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:P12004	Human	PMID:18499658
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:P35250	Human	PMID:18499658
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:P39748	Human	PMID:18499658
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:Q8WVB6	Human	PMID:18499658
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:Q9BVC3	Human	PMID:18499658
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:Q9UNS1	Human	PMID:20124417
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:O95602	Human	PMID:26089203
Molecular Function	GO:0005515	protein binding	DDX11	IPI	UniProtKB:P17480	Human	PMID:26089203
Molecular Function	GO:0003697	single-stranded DNA binding	DDX11	IDA		Human	PMID:9013641
Molecular Function	GO:0003727	single-stranded RNA binding	DDX11	IDA		Human	PMID:27477908
Molecular Function	GO:0045142	triplex DNA binding	DDX11	IDA		Human	PMID:26503245
Cellular Component	GO:0005813	centrosome	DDX11	IDA		Human	PMID:17105772
Cellular Component	GO:0000785	chromatin	DDX11	IDA		Human	PMID:17105772
Cellular Component	GO:0070062	extracellular exosome	DDX11	HDA		Human	PMID:18570454
Cellular Component	GO:0030496	midbody	DDX11	IDA		Human	PMID:17105772
Cellular Component	GO:0005730	nucleolus	DDX11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	DDX11	IDA		Human	PMID:26089203
Cellular Component	GO:0005730	nucleolus	DDX11	IDA		Human	PMID:9013641
Cellular Component	GO:0005654	nucleoplasm	DDX11	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DDX11	IDA		Human	PMID:17189189
Cellular Component	GO:0000922	spindle pole	DDX11	IDA		Human	PMID:17105772
Biological Process	GO:1904976	cellular response to bleomycin	DDX11	IMP		Human	PMID:23797032
Biological Process	GO:0072719	cellular response to cisplatin	DDX11	IMP		Human	PMID:23797032
Biological Process	GO:0072711	cellular response to hydroxyurea	DDX11	IMP		Human	PMID:23797032
Biological Process	GO:0072711	cellular response to hydroxyurea	DDX11	IMP		Human	PMID:26503245
Biological Process	GO:0006974	DNA damage response	DDX11	IMP		Human	PMID:23797032
Biological Process	GO:0032508	DNA duplex unwinding	DDX11	IDA		Human	PMID:10648783
Biological Process	GO:0032508	DNA duplex unwinding	DDX11	IDA		Human	PMID:18499658
Biological Process	GO:0032508	DNA duplex unwinding	DDX11	IDA		Human	PMID:26503245
Biological Process	GO:0044806	G-quadruplex DNA unwinding	DDX11	IDA		Human	PMID:26503245
Biological Process	GO:0032091	negative regulation of protein binding	DDX11	IMP		Human	PMID:26089203
Biological Process	GO:1990700	nucleolar chromatin organization	DDX11	IMP		Human	PMID:26089203
Biological Process	GO:1990700	nucleolar chromatin organization	ddx11	IMP	ZFIN:ZDB-MRPHLNO-160307-1	Zfish	PMID:26089203
Biological Process	GO:1990700	nucleolar chromatin organization	ddx11	IMP	ZFIN:ZDB-MRPHLNO-160307-2	Zfish	PMID:26089203
Biological Process	GO:0035563	positive regulation of chromatin binding	DDX11	IDA		Human	PMID:26089203
Biological Process	GO:2000781	positive regulation of double-strand break repair	DDX11	IMP		Human	PMID:23797032
Biological Process	GO:0032079	positive regulation of endodeoxyribonuclease activity	DDX11	IDA		Human	PMID:18499658
Biological Process	GO:0045876	positive regulation of sister chromatid cohesion	DDX11	IMP		Human	PMID:18499658
Biological Process	GO:0045876	positive regulation of sister chromatid cohesion	DDX11	IMP		Human	PMID:20124417
Biological Process	GO:0045876	positive regulation of sister chromatid cohesion	DDX11	IMP		Human	PMID:27477908
Biological Process	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	DDX11	IMP		Human	PMID:26089203
Biological Process	GO:1901836	regulation of transcription of nucleolar large rRNA by RNA polymerase I	ddx11	IMP	ZFIN:ZDB-MRPHLNO-160307-1	Zfish	PMID:26089203
Biological Process	GO:1901836	regulation of transcription of nucleolar large rRNA by RNA polymerase I	ddx11	IMP	ZFIN:ZDB-MRPHLNO-160307-2	Zfish	PMID:26089203
Biological Process	GO:0031297	replication fork processing	DDX11	IMP		Human	PMID:26503245
Biological Process	GO:0009303	rRNA transcription	ddx11	IMP	ZFIN:ZDB-MRPHLNO-160307-1	Zfish	PMID:26089203
Biological Process	GO:0009303	rRNA transcription	ddx11	IMP	ZFIN:ZDB-MRPHLNO-160307-2	Zfish	PMID:26089203
Biological Process	GO:0007062	sister chromatid cohesion	DDX11	IDA		Human	PMID:17105772

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern