Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DDX3X
  • Mouse genes Ddx3x
  • Rat genes Ddx3x
  • Zfish genes ddx3xa,ddx3xb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ddx3x

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016887	ATP hydrolysis activity	DDX3X	IDA		Human	PMID:10074132
Molecular Function	GO:0016887	ATP hydrolysis activity	DDX3X	IDA		Human	PMID:21589879
Molecular Function	GO:0045296	cadherin binding	DDX3X	HDA		Human	PMID:25468996
Molecular Function	GO:0043273	CTPase activity	DDX3X	IDA		Human	PMID:10074132
Molecular Function	GO:0003677	DNA binding	DDX3X	IDA		Human	PMID:21589879
Molecular Function	GO:0003678	DNA helicase activity	DDX3X	IDA		Human	PMID:21589879
Molecular Function	GO:0008190	eukaryotic initiation factor 4E binding	DDX3X	IDA		Human	PMID:17667941
Molecular Function	GO:0043015	gamma-tubulin binding	DDX3X	IDA		Human	PMID:28842590
Molecular Function	GO:0003924	GTPase activity	DDX3X	IDA		Human	PMID:10074132
Molecular Function	GO:0048027	mRNA 5'-UTR binding	DDX3X	IDA		Human	PMID:22872150
Molecular Function	GO:0003729	mRNA binding	DDX3X	IDA		Human	PMID:29062139
Molecular Function	GO:0008143	poly(A) binding	DDX3X	IDA		Human	PMID:18596238
Molecular Function	GO:0070878	primary miRNA binding	Ddx3x	IDA		Mouse	PMID:28819115
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P27958:PRO_0000037566	Human	PMID:10074132
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q5EG65:PRO_0000037559	Human	PMID:10329544
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P26664:PRO_0000037517	Human	PMID:10336476
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P27958:PRO_0000037566	Human	PMID:17855521
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P05198	Human	PMID:18596238
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P11940	Human	PMID:18596238
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q9UBU9	Human	PMID:18596238
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P55884	Human	PMID:18628297
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q99613	Human	PMID:18628297
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P68467	Human	PMID:18636090
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q14164	Human	PMID:18636090
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P25445	Human	PMID:18846110
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P49840	Human	PMID:18846110
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P49841	Human	PMID:18846110
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q9WMX2:PRO_0000037541	Human	PMID:18985028
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P68466	Human	PMID:19913487
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:O95786	Human	PMID:20127681
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q7Z434	Human	PMID:20127681
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q14164	Human	PMID:20657822
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P27958:PRO_0000037566	Human	PMID:20862261
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q15003	Human	PMID:21730191
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P11940	Human	PMID:21883093
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P05198	Human	PMID:22323517
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q99613	Human	PMID:22323517
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q99IB8	Human	PMID:22616990
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P68466	Human	PMID:22810585
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P11940	Human	PMID:22872150
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q04637	Human	PMID:22872150
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P49674	Human	PMID:23413191
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P03427	Human	PMID:23816991
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P04608	Human	PMID:23840900
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q9WMX2:PRO_0000037541	Human	PMID:24169621
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q923J1	Human	PMID:24855944
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q03468	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q9H6R0	Human	PMID:26100019
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q04206	Human	PMID:27736973
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:A7MCY6|UniProtKB:Q13114|UniProtKB:Q14164|UniProtKB:Q14653|UniProtKB:Q7Z434	Human	PMID:27980081
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P41235|UniProtKB:Q09472|UniProtKB:Q15466|UniProtKB:Q92793	Human	PMID:28128295
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P03427	Human	PMID:28611246
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P06730|UniProtKB:P11940|UniProtKB:Q14444	Human	PMID:28733330
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P04637	Human	PMID:28842590
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:P14240	Human	PMID:29261807
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q9HBA0	Human	PMID:29899501
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:O14980	Human	PMID:30131165
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:O15111	Human	PMID:30341167
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:O14980	Human	PMID:31575075
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q03403	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q6P582	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DDX3X	IPI	UniProtKB:Q8TF63	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ddx3x	IPI	UniProtKB:Q8R4B8	Mouse	MGI:MGI:6368386|PMID:31511697
Molecular Function	GO:0005515	protein binding	Ddx3x	IPI	UniProtKB:Q9UHD2	Mouse	MGI:MGI:5508590|PMID:18583960
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	DDX3X	IDA		Human	PMID:23413191
Molecular Function	GO:0017111	ribonucleoside triphosphate phosphatase activity	DDX3X	IDA		Human	PMID:10074132
Molecular Function	GO:0043024	ribosomal small subunit binding	DDX3X	IDA		Human	PMID:22323517
Molecular Function	GO:0003723	RNA binding	DDX3X	IDA		Human	PMID:21589879
Molecular Function	GO:0003723	RNA binding	DDX3X	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	DDX3X	HDA		Human	PMID:22681889
Molecular Function	GO:0003724	RNA helicase activity	DDX3X	IDA		Human	PMID:21589879
Molecular Function	GO:0003724	RNA helicase activity	DDX3X	IDA		Human	PMID:31575075
Molecular Function	GO:0035613	RNA stem-loop binding	DDX3X	IDA		Human	PMID:22872150
Molecular Function	GO:0033592	RNA strand annealing activity	DDX3X	IDA		Human	PMID:27546789
Molecular Function	GO:0035591	signaling adaptor activity	DDX3X	IDA		Human	PMID:23478265
Molecular Function	GO:0008134	transcription factor binding	DDX3X	IDA		Human	PMID:16818630
Molecular Function	GO:0031369	translation initiation factor binding	DDX3X	IDA		Human	PMID:22323517
Molecular Function	GO:0031369	translation initiation factor binding	DDX3X	IDA		Human	PMID:22872150
Cellular Component	GO:0031252	cell leading edge	DDX3X	IDA		Human	PMID:28733330
Cellular Component	GO:0005813	centrosome	DDX3X	IDA		Human	PMID:28842590
Cellular Component	GO:0005737	cytoplasm	DDX3X	IDA		Human	PMID:18636090
Cellular Component	GO:0005737	cytoplasm	DDX3X	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	DDX3X	IMP		Human	PMID:10074132
Cellular Component	GO:0005737	cytoplasm	DDX3X	IDA		Human	PMID:10329544
Cellular Component	GO:0005737	cytoplasm	DDX3X	IDA		Human	PMID:24965446
Cellular Component	GO:0005737	cytoplasm	DDX3X	IMP		Human	PMID:26100019
Cellular Component	GO:0005737	cytoplasm	DDX3X	IDA		Human	PMID:27736973
Cellular Component	GO:0005737	cytoplasm	DDX3X	IDA		Human	PMID:28733330
Cellular Component	GO:0005737	cytoplasm	DDX3X	IDA		Human	PMID:30131165
Cellular Component	GO:0005737	cytoplasm	DDX3X	IDA		Human	PMID:30341167
Cellular Component	GO:0005737	cytoplasm	DDX3X	IDA		Human	PMID:31575075
Cellular Component	GO:0010494	cytoplasmic stress granule	DDX3X	IDA		Human	PMID:18596238
Cellular Component	GO:0010494	cytoplasmic stress granule	DDX3X	IDA		Human	PMID:21883093
Cellular Component	GO:0010494	cytoplasmic stress granule	Ddx3x	IDA		Mouse	MGI:MGI:6368386|PMID:31511697
Cellular Component	GO:0005829	cytosol	DDX3X	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	DDX3X	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	DDX3X	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	DDX3X	HDA		Human	PMID:20458337
Cellular Component	GO:0072559	NLRP3 inflammasome complex	Ddx3x	IDA		Mouse	MGI:MGI:6368386|PMID:31511697
Cellular Component	GO:0005654	nucleoplasm	DDX3X	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DDX3X	IDA		Human	PMID:10074132
Cellular Component	GO:0005634	nucleus	DDX3X	IDA		Human	PMID:10329544
Cellular Component	GO:0005634	nucleus	DDX3X	IDA		Human	PMID:29899501
Cellular Component	GO:0005634	nucleus	DDX3X	IDA		Human	PMID:30131165
Cellular Component	GO:0005634	nucleus	DDX3X	IDA		Human	PMID:31575075
Cellular Component	GO:0005886	plasma membrane	DDX3X	IDA		Human	PMID:29899501
Biological Process	GO:0007420	brain development	ddx3xb	IMP	ZFIN:ZDB-MRPHLNO-151109-9	Zfish	PMID:25533962
Biological Process	GO:0071243	cellular response to arsenic-containing substance	DDX3X	IDA		Human	PMID:21883093
Biological Process	GO:0071470	cellular response to osmotic stress	DDX3X	IDA		Human	PMID:21883093
Biological Process	GO:0098586	cellular response to virus	DDX3X	IDA		Human	PMID:31575075
Biological Process	GO:0007059	chromosome segregation	DDX3X	IMP		Human	PMID:21730191
Biological Process	GO:0042256	cytosolic ribosome assembly	DDX3X	IMP		Human	PMID:22323517
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	DDX3X	IMP		Human	PMID:18846110
Biological Process	GO:0045087	innate immune response	DDX3X	IMP		Human	PMID:18583960
Biological Process	GO:0035556	intracellular signal transduction	DDX3X	IDA		Human	PMID:18636090
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	DDX3X	IMP		Human	PMID:16301996
Biological Process	GO:0055088	lipid homeostasis	DDX3X	IMP		Human	PMID:28128295
Biological Process	GO:0043066	negative regulation of apoptotic process	DDX3X	IMP		Human	PMID:18846110
Biological Process	GO:0030308	negative regulation of cell growth	DDX3X	IDA		Human	PMID:16818630
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	DDX3X	IMP		Human	PMID:18846110
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	DDX3X	IMP		Human	PMID:18846110
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	DDX3X	IMP		Human	PMID:21883093
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	DDX3X	IMP		Human	PMID:27736973
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	DDX3X	IDA		Human	PMID:17667941
Biological Process	GO:0017148	negative regulation of translation	DDX3X	IMP		Human	PMID:17667941
Biological Process	GO:0030593	neutrophil chemotaxis	ddx3xa	IMP		Zfish	PMID:30373933
Biological Process	GO:0030593	neutrophil chemotaxis	ddx3xb	IGI	ZFIN:ZDB-GENE-030131-1565	Zfish	PMID:30373933
Biological Process	GO:0030593	neutrophil chemotaxis	ddx3xb	IMP		Zfish	PMID:30373933
Biological Process	GO:0030593	neutrophil chemotaxis	ddx3xa	IGI	ZFIN:ZDB-GENE-980526-150	Zfish	PMID:30373933
Biological Process	GO:0043065	positive regulation of apoptotic process	DDX3X	IMP		Human	PMID:16301996
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	DDX3X	IMP		Human	PMID:23413191
Biological Process	GO:0030307	positive regulation of cell growth	DDX3X	IMP		Human	PMID:18628297
Biological Process	GO:0030307	positive regulation of cell growth	DDX3X	IMP		Human	PMID:20837705
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	DDX3X	IMP		Human	PMID:16301996
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	DDX3X	IMP		Human	PMID:20837705
Biological Process	GO:0010628	positive regulation of gene expression	DDX3X	IDA		Human	PMID:10074132
Biological Process	GO:0032727	positive regulation of interferon-alpha production	DDX3X	IDA		Human	PMID:30341167
Biological Process	GO:0032728	positive regulation of interferon-beta production	DDX3X	IDA		Human	PMID:27980081
Biological Process	GO:0032728	positive regulation of interferon-beta production	DDX3X	IDA		Human	PMID:31575075
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	DDX3X	IMP		Human	PMID:30341167
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Ddx3x	IDA		Mouse	MGI:MGI:6368386|PMID:31511697
Biological Process	GO:1901985	positive regulation of protein acetylation	DDX3X	IMP		Human	PMID:28128295
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	DDX3X	IDA		Human	PMID:30341167
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	DDX3X	IDA		Human	PMID:27980081
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	DDX3X	IDA		Human	PMID:23413191
Biological Process	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	DDX3X	IDA		Human	PMID:30341167
Biological Process	GO:0034161	positive regulation of toll-like receptor 8 signaling pathway	DDX3X	IDA		Human	PMID:30341167
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DDX3X	IDA		Human	PMID:16818630
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DDX3X	IMP		Human	PMID:18583960
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DDX3X	IDA		Human	PMID:18636090
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DDX3X	IDA		Human	PMID:28128295
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DDX3X	IMP		Human	PMID:28842590
Biological Process	GO:0045727	positive regulation of translation	DDX3X	IDA		Human	PMID:18596238
Biological Process	GO:0045727	positive regulation of translation	DDX3X	IDA		Human	PMID:22872150
Biological Process	GO:0045727	positive regulation of translation	DDX3X	IMP		Human	PMID:28842590
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	DDX3X	IMP		Human	PMID:29062139
Biological Process	GO:0045948	positive regulation of translational initiation	DDX3X	IMP		Human	PMID:20837705
Biological Process	GO:0032481	positive regulation of type I interferon production	DDX3X	IDA		Human	PMID:23478265
Biological Process	GO:0045070	positive regulation of viral genome replication	DDX3X	IMP		Human	PMID:20862261
Biological Process	GO:0031053	primary miRNA processing	Ddx3x	IMP		Mouse	PMID:28819115
Biological Process	GO:0031053	primary miRNA processing	Ddx3x	IDA		Mouse	PMID:28819115
Biological Process	GO:1903608	protein localization to cytoplasmic stress granule	DDX3X	IMP		Human	PMID:24965446
Biological Process	GO:0009615	response to virus	DDX3X	IDA		Human	PMID:18636090
Biological Process	GO:0010501	RNA secondary structure unwinding	DDX3X	IDA		Human	PMID:22872150
Biological Process	GO:0034063	stress granule assembly	DDX3X	IDA		Human	PMID:21883093
Biological Process	GO:0034063	stress granule assembly	Ddx3x	IMP		Mouse	MGI:MGI:6368386|PMID:31511697
Biological Process	GO:0006413	translational initiation	DDX3X	IMP		Human	PMID:26100019
Biological Process	GO:0016055	Wnt signaling pathway	DDX3X	IMP		Human	PMID:26235985

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern