Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DDX5
  • Mouse genes Ddx5
  • Rat genes Ddx5
  • Zfish genes ddx5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ddx5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048306	calcium-dependent protein binding	Ddx5	IDA		Rat	PMID:7525583|RGD:5128519
Molecular Function	GO:0005516	calmodulin binding	Ddx5	IDA		Rat	PMID:7525583|RGD:5128519
Molecular Function	GO:0019899	enzyme binding	Ddx5	IDA		Rat	PMID:19224332|RGD:5128521
Molecular Function	GO:0035500	MH2 domain binding	DDX5	IPI	UniProtKB:Q15797	Human	PMID:18548003
Molecular Function	GO:0003730	mRNA 3'-UTR binding	DDX5	IDA		Human	PMID:23788676
Molecular Function	GO:0003730	mRNA 3'-UTR binding	ddx5	IDA		Zfish	PMID:31227602
Molecular Function	GO:0050681	nuclear androgen receptor binding	DDX5	IDA		Human	PMID:18829551
Molecular Function	GO:0036002	pre-mRNA binding	DDX5	IDA		Human	PMID:21343338
Molecular Function	GO:0070878	primary miRNA binding	DDX5	IDA		Human	PMID:18548003
Molecular Function	GO:1990841	promoter-specific chromatin binding	Ddx5	IDA		Mouse	MGI:MGI:5883203|PMID:24910439
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P22087	Human	PMID:10837141
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P24928	Human	PMID:12527917
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P45481	Human	PMID:12527917
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q09472	Human	PMID:12527917
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P27958:PRO_0000037577	Human	PMID:15113910
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q13547	Human	PMID:15298701
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P04637	Human	PMID:15660129
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P27958:PRO_0000037566	Human	PMID:15846844
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P10085	Human	PMID:17011493
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P24928	Human	PMID:17011493
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q9UKV8	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q9UL18	Human	PMID:17932509
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q08775-3	Human	PMID:17960593
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q9H2U1	Human	PMID:18279852
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q8AZK7	Human	PMID:18457437
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P84022	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q15797	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q99717	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q9NRR4	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q9NRR4	Human	PMID:19626115
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:O95983	Human	PMID:20676135
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q12873	Human	PMID:20676135
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P04637-1	Human	PMID:20818423
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P04637-7	Human	PMID:20818423
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q9BWF3	Human	PMID:21343338
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P29991:PRO_0000308465	Human	PMID:21911577
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q1K9H5	Human	PMID:21994455
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q9NRR4	Human	PMID:22222205
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:O94916	Human	PMID:22266867
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q92841	Human	PMID:22365833
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P27958:PRO_0000037577	Human	PMID:22640416
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q01780	Human	PMID:23143267
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P04618	Human	PMID:23741449
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P06730|UniProtKB:P11940|UniProtKB:P61326|UniProtKB:Q04637|UniProtKB:Q09161|UniProtKB:Q86U42|UniProtKB:Q92900|UniProtKB:Q9BZI7|UniProtKB:Q9HAU5	Human	PMID:23788676
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P04637	Human	PMID:24219989
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q92841	Human	PMID:24581491
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:O00192	Human	PMID:24644279
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P31943	Human	PMID:24910439
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:P19712:PRO_0000038050	Human	PMID:24965446
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q03468	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q15637	Human	PMID:26420826
Molecular Function	GO:0005515	protein binding	DDX5	IPI	UniProtKB:Q13148	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ddx5	IPI	UniProtKB:Q63014	Mouse	MGI:MGI:5810265|PMID:11279182
Molecular Function	GO:0005515	protein binding	Ddx5	IPI	UniProtKB:O35737	Mouse	MGI:MGI:5883203|PMID:24910439
Molecular Function	GO:0005515	protein binding	Ddx5	IPI	UniProtKB:Q91Y44	Mouse	MGI:MGI:5448498|PMID:22570411
Molecular Function	GO:0005515	protein binding	Ddx5	IPI	PR:O54943	Mouse	PMID:22767893
Molecular Function	GO:0005515	protein binding	Ddx5	IPI	PR:O70133	Mouse	PMID:22767893
Molecular Function	GO:0005515	protein binding	Ddx5	IPI	PR:Q8BUN5	Mouse	PMID:15464984
Molecular Function	GO:0005515	protein binding	Ddx5	IPI	PR:Q9WTK0	Mouse	PMID:19723804
Molecular Function	GO:0005515	protein binding	Ddx5	IPI	UniProtKB:Q08775	Rat	PMID:17960593|RGD:8554567
Molecular Function	GO:0005515	protein binding	Ddx5	IPI	UniProtKB:A0A3G5BIY8	Rat	PMID:19224332|RGD:5128521
Molecular Function	GO:0070412	R-SMAD binding	DDX5	IPI	UniProtKB:Q99717	Human	PMID:18548003
Molecular Function	GO:0043021	ribonucleoprotein complex binding	DDX5	IDA		Human	PMID:23788676
Molecular Function	GO:0003723	RNA binding	DDX5	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	DDX5	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	Ddx5	IDA		Mouse	PMID:22665494
Molecular Function	GO:0003724	RNA helicase activity	DDX5	IMP		Human	PMID:21343338
Molecular Function	GO:0003724	RNA helicase activity	Ddx5	IDA		Rat	PMID:7525583|RGD:5128519
Molecular Function	GO:0046332	SMAD binding	DDX5	IPI	UniProtKB:P84022	Human	PMID:18548003
Molecular Function	GO:0003712	transcription coregulator activity	Ddx5	IDA		Mouse	PMID:15464984
Cellular Component	GO:0071013	catalytic step 2 spliceosome	DDX5	IDA		Human	PMID:11991638
Cellular Component	GO:0070062	extracellular exosome	DDX5	HDA		Human	PMID:19056867
Cellular Component	GO:0016020	membrane	DDX5	HDA		Human	PMID:19946888
Cellular Component	GO:0016607	nuclear speck	DDX5	IDA		Human	PMID:24644279
Cellular Component	GO:0005730	nucleolus	DDX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	DDX5	IDA		Human	PMID:10837141
Cellular Component	GO:0005654	nucleoplasm	DDX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DDX5	HDA		Human	PMID:16791210
Cellular Component	GO:0005634	nucleus	DDX5	IDA		Human	PMID:24910439
Cellular Component	GO:1990904	ribonucleoprotein complex	DDX5	IDA		Human	PMID:18809582
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	DDX5	IMP		Human	PMID:24275493
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	DDX5	IMP		Human	PMID:24910439
Biological Process	GO:0000380	alternative mRNA splicing, via spliceosome	Ddx5	IMP		Mouse	MGI:MGI:5883203|PMID:24910439
Biological Process	GO:0030521	androgen receptor signaling pathway	DDX5	IMP		Human	PMID:24275493
Biological Process	GO:0030509	BMP signaling pathway	DDX5	IMP		Human	PMID:18548003
Biological Process	GO:0007623	circadian rhythm	Ddx5	IMP		Mouse	PMID:22767893
Biological Process	GO:0001837	epithelial to mesenchymal transition	DDX5	IMP		Human	PMID:24910439
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	DDX5	IMP		Human	PMID:24275493
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	DDX5	IMP		Human	PMID:15660129
Biological Process	GO:0061614	miRNA transcription	Ddx5	IMP		Mouse	MGI:MGI:5883203|PMID:24910439
Biological Process	GO:0009299	mRNA transcription	DDX5	IMP		Human	PMID:23143267
Biological Process	GO:0045445	myoblast differentiation	Ddx5	IMP		Mouse	MGI:MGI:5883203|PMID:24910439
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DDX5	IDA		Human	PMID:15298701
Biological Process	GO:0000956	nuclear-transcribed mRNA catabolic process	DDX5	IDA		Human	PMID:23788676
Biological Process	GO:0001556	oocyte maturation	ddx5	IMP	ZFIN:ZDB-GENO-211208-5	Zfish	PMID:32873816
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	DDX5	IMP		Human	PMID:15660129
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ddx5	IDA		Mouse	PMID:15464984
Biological Process	GO:0031053	primary miRNA processing	DDX5	IMP		Human	PMID:18548003
Biological Process	GO:0006606	protein import into nucleus	Ddx5	IGI	MGI:MGI:5440479	Mouse	PMID:22665494
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	DDX5	IDA		Human	PMID:21343338
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	DDX5	IMP		Human	PMID:23022728
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	Ddx5	IDA		Mouse	MGI:MGI:5819339|PMID:23022728
Biological Process	GO:0060765	regulation of androgen receptor signaling pathway	DDX5	IMP		Human	PMID:18829551
Biological Process	GO:0045667	regulation of osteoblast differentiation	Ddx5	IMP		Mouse	MGI:MGI:5315698|PMID:17960593
Biological Process	GO:2001014	regulation of skeletal muscle cell differentiation	Ddx5	IMP		Mouse	MGI:MGI:5315343|PMID:17011493
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	DDX5	IMP		Human	PMID:24275493
Biological Process	GO:0045069	regulation of viral genome replication	Ddx5	IMP		Rat	PMID:19224332|RGD:5128521

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern