Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DEF6
  • Mouse genes Def6
  • Rat genes Def6
  • Zfish genes def6a,def6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Def6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:I6L996	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:O15162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:P15884	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q00587	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q8IX15-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q96AQ6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q9NRA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:P62491	Human	PMID:31308374
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:P15884	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:A6NC98	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:I6L996	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:O00422	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:O95391	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:P0C7X2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:P25786	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q0VD86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q7Z5H3-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q86T90	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q86YV0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q8WZA2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q96JM7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q96N21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q9H0H0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEF6	IPI	UniProtKB:Q9NYA3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Def6	IPI	UniProtKB:Q61738-6	Mouse	MGI:MGI:3715039|PMID:17403664
Cellular Component	GO:0005911	cell-cell junction	Def6	IDA		Mouse	PMID:23793062
Cellular Component	GO:0005829	cytosol	DEF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	DEF6	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	DEF6	IDA		Human	GO_REF:0000052
Biological Process	GO:0042074	cell migration involved in gastrulation	def6a	IMP	ZFIN:ZDB-MRPHLNO-111207-2	Zfish	PMID:22039507
Biological Process	GO:0042074	cell migration involved in gastrulation	def6a	IMP	ZFIN:ZDB-MRPHLNO-111207-3	Zfish	PMID:22039507
Biological Process	GO:0060026	convergent extension	def6a	IMP	ZFIN:ZDB-MRPHLNO-111207-2	Zfish	PMID:24177263
Biological Process	GO:0060026	convergent extension	def6a	IGI	ZFIN:ZDB-MRPHLNO-111207-2,ZFIN:ZDB-MRPHLNO-140306-3	Zfish	PMID:24177263
Biological Process	GO:0060026	convergent extension	def6a	IGI	ZFIN:ZDB-GENE-030131-3587,ZFIN:ZDB-MRPHLNO-111207-2	Zfish	PMID:24177263
Biological Process	GO:0060027	convergent extension involved in gastrulation	def6a	IMP	ZFIN:ZDB-MRPHLNO-111207-3	Zfish	PMID:22039507
Biological Process	GO:0060027	convergent extension involved in gastrulation	def6a	IMP	ZFIN:ZDB-MRPHLNO-111207-2	Zfish	PMID:22039507
Biological Process	GO:0098876	vesicle-mediated transport to the plasma membrane	DEF6	IMP		Human	PMID:31308374

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern