Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DEFA1,DEFA1B,DEFA3,DEFA4,DEFA5,DEFA6
  • Mouse genes Defa-rs2
  • Rat genes Defal1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Defa-rs2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140911	pore-forming activity	DEFA1	IDA		Human	PMID:17635867
Molecular Function	GO:0005515	protein binding	DEFA1	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEFA5	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q9UMX0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	DEFA4	IDA		Human	PMID:17088326
Molecular Function	GO:0042803	protein homodimerization activity	DEFA3	IDA		Human	PMID:2006422
Molecular Function	GO:0042803	protein homodimerization activity	DEFA5	IDA		Human	PMID:17088326
Molecular Function	GO:0042803	protein homodimerization activity	DEFA5	IDA		Human	PMID:22573326
Molecular Function	GO:0042803	protein homodimerization activity	DEFA5	IDA		Human	PMID:25782105
Molecular Function	GO:0042803	protein homodimerization activity	DEFA6	IDA		Human	PMID:17088326
Cellular Component	GO:0042582	azurophil granule	DEFA4	IDA		Human	PMID:2500436
Cellular Component	GO:0062023	collagen-containing extracellular matrix	DEFA1	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	DEFA1	HDA		Human	PMID:27559042
Cellular Component	GO:0070062	extracellular exosome	DEFA1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	DEFA1	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	DEFA3	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	DEFA1	IDA		Human	PMID:12860195
Cellular Component	GO:0005615	extracellular space	DEFA1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	DEFA1	IDA		Human	PMID:21861873
Cellular Component	GO:0005615	extracellular space	DEFA3	IDA		Human	PMID:12860195
Cellular Component	GO:0005615	extracellular space	DEFA3	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	DEFA3	IDA		Human	PMID:21861873
Cellular Component	GO:0005615	extracellular space	DEFA5	IDA		Human	PMID:9588893
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	DEFA5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030496	midbody	DEFA5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030141	secretory granule	DEFA5	IDA		Human	PMID:9588893
Cellular Component	GO:0030141	secretory granule	Defa-rs2	IDA		Mouse	PMID:20056603
Biological Process	GO:0019731	antibacterial humoral response	DEFA4	IDA		Human	PMID:2500436
Biological Process	GO:0019731	antibacterial humoral response	DEFA1	IDA		Human	PMID:12860195
Biological Process	GO:0019731	antibacterial humoral response	DEFA3	IDA		Human	PMID:12860195
Biological Process	GO:0019732	antifungal humoral response	DEFA4	IDA		Human	PMID:2500436
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFA4	IDA		Human	PMID:2500436
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFA1	IDA		Human	PMID:12860195
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFA1	IMP		Human	PMID:17635867
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFA3	IDA		Human	PMID:12860195
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFA5	IDA		Human	PMID:12660734
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFA5	IDA		Human	PMID:25782105
Biological Process	GO:0019730	antimicrobial humoral response	DEFA4	IDA		Human	PMID:2500436
Biological Process	GO:0042742	defense response to bacterium	Defa-rs2	IDA		Mouse	PMID:20056603
Biological Process	GO:0050832	defense response to fungus	DEFA4	IDA		Human	PMID:2500436
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFA4	IDA		Human	PMID:2500436
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFA5	IDA		Human	PMID:12660734
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFA5	IDA		Human	PMID:19589339
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFA5	IMP		Human	PMID:21861459
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFA5	IDA		Human	PMID:22573326
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFA5	IDA		Human	PMID:25354318
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFA5	IDA		Human	PMID:30808760
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFA4	IDA		Human	PMID:2500436
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFA1	IDA		Human	PMID:12860195
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFA3	IDA		Human	PMID:12860195
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFA5	IDA		Human	PMID:19589339
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFA5	IMP		Human	PMID:21861459
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFA5	IDA		Human	PMID:22573326
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFA5	IDA		Human	PMID:25354318
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFA5	IDA		Human	PMID:30808760
Biological Process	GO:0042832	defense response to protozoan	DEFA1	IMP		Human	PMID:17635867
Biological Process	GO:0044364	disruption of cells of another organism	DEFA5	IDA		Human	PMID:25782105
Biological Process	GO:0051673	disruption of membrane integrity in another organism	Defa-rs2	IDA		Mouse	PMID:20056603
Biological Process	GO:0045087	innate immune response	DEFA4	IDA		Human	PMID:2500436
Biological Process	GO:0045087	innate immune response	DEFA5	IMP		Human	PMID:21861459
Biological Process	GO:0002227	innate immune response in mucosa	DEFA1	IDA		Human	PMID:12860195
Biological Process	GO:0002227	innate immune response in mucosa	DEFA3	IDA		Human	PMID:12860195
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	DEFA1	IDA		Human	PMID:21861873
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	DEFA3	IDA		Human	PMID:21861873
Biological Process	GO:0051873	killing by host of symbiont cells	DEFA1	IDA		Human	PMID:17635867
Biological Process	GO:0051873	killing by host of symbiont cells	DEFA5	IDA		Human	PMID:9169780
Biological Process	GO:0031640	killing of cells of another organism	DEFA1	IDA		Human	PMID:17088326
Biological Process	GO:0031640	killing of cells of another organism	DEFA3	IDA		Human	PMID:15616305
Biological Process	GO:0031640	killing of cells of another organism	DEFA5	IDA		Human	PMID:15616305
Biological Process	GO:0031640	killing of cells of another organism	DEFA5	IDA		Human	PMID:17088326
Biological Process	GO:0032757	positive regulation of interleukin-8 production	DEFA5	IDA		Human	PMID:19589339
Biological Process	GO:1905710	positive regulation of membrane permeability	DEFA5	IMP		Human	PMID:21861459
Biological Process	GO:0051289	protein homotetramerization	DEFA5	IDA		Human	PMID:23163963
Biological Process	GO:0010818	T cell chemotaxis	DEFA1	IDA		Human	PMID:17088326

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern