Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DEFA3,DEFA6
  • Mouse genes Defa22
  • Rat genes Defa24
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Defa22

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q9UMX0	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DEFA6	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	DEFA3	IDA		Human	PMID:2006422
Molecular Function	GO:0042803	protein homodimerization activity	DEFA6	IDA		Human	PMID:17088326
Cellular Component	GO:0070062	extracellular exosome	DEFA3	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	DEFA3	IDA		Human	PMID:12860195
Cellular Component	GO:0005615	extracellular space	DEFA3	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	DEFA3	IDA		Human	PMID:21861873
Biological Process	GO:0019731	antibacterial humoral response	DEFA3	IDA		Human	PMID:12860195
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFA3	IDA		Human	PMID:12860195
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFA3	IDA		Human	PMID:12860195
Biological Process	GO:0002227	innate immune response in mucosa	DEFA3	IDA		Human	PMID:12860195
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	DEFA3	IDA		Human	PMID:21861873
Biological Process	GO:0031640	killing of cells of another organism	DEFA3	IDA		Human	PMID:15616305

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern