Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DEFB1
  • Mouse genes Defb1
  • Rat genes Defb1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Defb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031731	CCR6 chemokine receptor binding	DEFB1	IDA		Human	PMID:25122636
Molecular Function	GO:0042802	identical protein binding	DEFB1	IDA		Human	PMID:23938203
Molecular Function	GO:0005515	protein binding	DEFB1	IPI	UniProtKB:P51684	Human	PMID:25122636
Molecular Function	GO:0005515	protein binding	DEFB1	IPI	UniProtKB:Q12797-6	Human	PMID:32296183
Cellular Component	GO:0070062	extracellular exosome	DEFB1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	DEFB1	IDA		Human	PMID:12860195
Cellular Component	GO:0005615	extracellular space	DEFB1	IDA		Human	PMID:21115716
Cellular Component	GO:0019898	extrinsic component of membrane	DEFB1	IDA		Human	PMID:23938203
Cellular Component	GO:1990742	microvesicle	DEFB1	IDA		Human	PMID:23938203
Cellular Component	GO:0097225	sperm midpiece	DEFB1	IDA		Human	PMID:25122636
Biological Process	GO:0002526	acute inflammatory response	Defb1	IEP		Rat	PMID:16704867|RGD:4892270
Biological Process	GO:0019731	antibacterial humoral response	DEFB1	IDA		Human	PMID:12860195
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFB1	IDA		Human	PMID:12860195
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFB1	IMP		Human	PMID:25122636
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	DEFB1	IDA		Human	PMID:25122636
Biological Process	GO:0019933	cAMP-mediated signaling	DEFB1	IDA		Human	PMID:25122636
Biological Process	GO:0042742	defense response to bacterium	DEFB1	IMP		Human	PMID:21115716
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFB1	IMP		Human	PMID:25122636
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFB1	IDA		Human	PMID:12860195
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFB1	IMP		Human	PMID:25122636
Biological Process	GO:0045087	innate immune response	Defb1	IMP		Mouse	MGI:MGI:2179639|PMID:12010999
Biological Process	GO:0002227	innate immune response in mucosa	DEFB1	IDA		Human	PMID:12860195
Biological Process	GO:0060474	positive regulation of flagellated sperm motility involved in capacitation	DEFB1	IMP		Human	PMID:25122636
Biological Process	GO:0009617	response to bacterium	DEFB1	IDA		Human	PMID:12054642
Biological Process	GO:0009617	response to bacterium	Defb1	IMP		Mouse	MGI:MGI:2179639|PMID:12010999
Biological Process	GO:0033574	response to testosterone	Defb1	IEP		Rat	PMID:12533413|RGD:4892272

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern