Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DEFB118
  • Mouse genes Defb21
  • Rat genes Defb21
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Defb21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001530	lipopolysaccharide binding	DEFB118	IDA		Human	PMID:33181266
Molecular Function	GO:0005515	protein binding	DEFB118	IPI	UniProtKB:P43080	Human	PMID:32296183
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFB118	IDA		Human	PMID:15033915
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFB118	IDA		Human	PMID:15033915
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFB118	IDA		Human	PMID:33224970
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFB118	IDA		Human	PMID:33224970
Biological Process	GO:0052337	disruption by host of symbiont membrane	DEFB118	IDA		Human	PMID:15033915
Biological Process	GO:0045087	innate immune response	DEFB118	IDA		Human	PMID:33224970
Biological Process	GO:0031640	killing of cells of another organism	DEFB118	IDA		Human	PMID:15033915
Biological Process	GO:0031640	killing of cells of another organism	DEFB118	IDA		Human	PMID:33224970
Biological Process	GO:0007162	negative regulation of cell adhesion	DEFB118	IDA		Human	PMID:33224970
Biological Process	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	DEFB118	IDA		Human	PMID:33181266

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern