Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DEFB4A,DEFB4B
  • Mouse genes Defb3
  • Rat genes Defb3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Defb3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031731	CCR6 chemokine receptor binding	DEFB4A	IDA		Human	PMID:20068036
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	DEFB4A	IDA		Human	PMID:30050988
Molecular Function	GO:0005515	protein binding	DEFB4A	IPI	UniProtKB:O54689	Human	PMID:20068036
Molecular Function	GO:0005515	protein binding	DEFB4A	IPI	UniProtKB:P51684	Human	PMID:20068036
Cellular Component	GO:0005615	extracellular space	DEFB4A	IDA		Human	PMID:21115716
Cellular Component	GO:0005615	extracellular space	DEFB4A	IDA		Human	PMID:9727055
Biological Process	GO:0061760	antifungal innate immune response	DEFB4A	IDA		Human	PMID:30050988
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFB4A	IDA		Human	PMID:30050988
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	DEFB4A	IMP		Human	PMID:9727055
Biological Process	GO:0006935	chemotaxis	DEFB4A	IDA		Human	PMID:20068036
Biological Process	GO:0042742	defense response to bacterium	DEFB4A	IMP		Human	PMID:21115716
Biological Process	GO:0042742	defense response to bacterium	Defb3	IMP	MGI:MGI:5519129	Mouse	PMID:23670560
Biological Process	GO:0042742	defense response to bacterium	Defb3	IMP	MGI:MGI:3528568	Mouse	PMID:21115716
Biological Process	GO:0050832	defense response to fungus	DEFB4A	IDA		Human	PMID:30050988
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFB4A	IDA		Human	PMID:15625724
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DEFB4A	IDA		Human	PMID:20068036
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFB4A	IDA		Human	PMID:15625724
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DEFB4A	IDA		Human	PMID:20068036
Biological Process	GO:0044364	disruption of cells of another organism	DEFB4A	IDA		Human	PMID:30050988
Biological Process	GO:0031640	killing of cells of another organism	DEFB4A	IDA		Human	PMID:15625724
Biological Process	GO:0031640	killing of cells of another organism	DEFB4A	IDA		Human	PMID:30050988
Biological Process	GO:0031640	killing of cells of another organism	DEFB4A	IMP		Human	PMID:9727055

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern