Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DGAT2
  • Mouse genes Dgat2
  • Rat genes Dgat2
  • Zfish genes dgat2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dgat2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003846	2-acylglycerol O-acyltransferase activity	Dgat2	IDA		Mouse	PMID:12077311
Molecular Function	GO:0004144	diacylglycerol O-acyltransferase activity	DGAT2	EXP		Human	PMID:11481335
Molecular Function	GO:0004144	diacylglycerol O-acyltransferase activity	DGAT2	IDA		Human	PMID:11481335
Molecular Function	GO:0004144	diacylglycerol O-acyltransferase activity	DGAT2	IDA		Human	PMID:27184406
Molecular Function	GO:0004144	diacylglycerol O-acyltransferase activity	Dgat2	IMP		Mouse	PMID:21680734
Molecular Function	GO:0004144	diacylglycerol O-acyltransferase activity	Dgat2	IDA		Mouse	PMID:11481335
Molecular Function	GO:0004144	diacylglycerol O-acyltransferase activity	Dgat2	IDA		Mouse	PMID:24953780
Molecular Function	GO:0004144	diacylglycerol O-acyltransferase activity	Dgat2	IDA		Mouse	PMID:12077311
Molecular Function	GO:0004144	diacylglycerol O-acyltransferase activity	Dgat2	IDA		Rat	PMID:12235188|RGD:634740
Molecular Function	GO:0005515	protein binding	DGAT2	IPI	UniProtKB:Q6PCB7	Human	PMID:30970241
Molecular Function	GO:0042803	protein homodimerization activity	Dgat2	IPI	UniProtKB:Q9DCV3	Mouse	MGI:MGI:5293272|PMID:21680734
Cellular Component	GO:0005829	cytosol	DGAT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	DGAT2	IDA		Human	PMID:14521909
Cellular Component	GO:0005783	endoplasmic reticulum	Dgat2	IDA		Mouse	MGI:MGI:3842895|PMID:19049983
Cellular Component	GO:0005783	endoplasmic reticulum	Dgat2	IDA		Mouse	PMID:24953780
Cellular Component	GO:0005789	endoplasmic reticulum membrane	DGAT2	IDA		Human	PMID:27184406
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Dgat2	IDA		Mouse	MGI:MGI:5293272|PMID:21680734
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Dgat2	IDA		Mouse	PMID:21680734
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	DGAT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Dgat2	IDA		Rat	PMID:12235188|RGD:634740
Cellular Component	GO:0005811	lipid droplet	DGAT2	IDA		Human	PMID:27184406
Cellular Component	GO:0005811	lipid droplet	Dgat2	IDA		Mouse	MGI:MGI:3842895|PMID:19049983
Cellular Component	GO:0005811	lipid droplet	Dgat2	IDA		Mouse	MGI:MGI:5293272|PMID:21680734
Cellular Component	GO:0016020	membrane	DGAT2	IDA		Human	PMID:11481335
Cellular Component	GO:0016020	membrane	Dgat2	IDA		Mouse	PMID:12077311
Cellular Component	GO:0016020	membrane	Dgat2	IDA		Mouse	PMID:11481335
Cellular Component	GO:0005739	mitochondrion	Dgat2	IDA		Mouse	MGI:MGI:3842895|PMID:19049983
Cellular Component	GO:1990578	perinuclear endoplasmic reticulum membrane	DGAT2	IDA		Human	PMID:27184406
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Dgat2	IDA		Mouse	MGI:MGI:3842895|PMID:19049983
Biological Process	GO:0038183	bile acid signaling pathway	Dgat2	IEP		Rat	PMID:25263431|RGD:15045610
Biological Process	GO:0071400	cellular response to oleic acid	Dgat2	IMP		Mouse	MGI:MGI:5293272|PMID:21680734
Biological Process	GO:0042632	cholesterol homeostasis	Dgat2	IMP		Mouse	MGI:MGI:3778742|PMID:18252207
Biological Process	GO:0006651	diacylglycerol biosynthetic process	Dgat2	IDA		Mouse	MGI:MGI:5465510|PMID:23066022
Biological Process	GO:0046339	diacylglycerol metabolic process	DGAT2	IDA		Human	PMID:11481335
Biological Process	GO:0046339	diacylglycerol metabolic process	Dgat2	IDA		Mouse	MGI:MGI:2151970|PMID:11481335
Biological Process	GO:0046339	diacylglycerol metabolic process	Dgat2	IMP		Rat	PMID:17526931|RGD:10400884
Biological Process	GO:0060613	fat pad development	Dgat2	IMP		Mouse	MGI:MGI:3778742|PMID:18252207
Biological Process	GO:0055089	fatty acid homeostasis	Dgat2	IGI	UniProtKB:Q9Z2A7	Mouse	MGI:MGI:3778742|PMID:18252207
Biological Process	GO:0035356	intracellular triglyceride homeostasis	Dgat2	IMP		Mouse	MGI:MGI:3036977|PMID:14668353
Biological Process	GO:0055088	lipid homeostasis	dgat2	IGI	ZFIN:ZDB-MRPHLNO-170719-1,ZFIN:ZDB-MRPHLNO-170719-2	Zfish	PMID:28027591
Biological Process	GO:0019915	lipid storage	Dgat2	IGI	UniProtKB:Q9DCV3	Mouse	MGI:MGI:5306738|PMID:21317108
Biological Process	GO:0019915	lipid storage	Dgat2	IMP		Mouse	MGI:MGI:5293272|PMID:21680734
Biological Process	GO:0035336	long-chain fatty-acyl-CoA metabolic process	DGAT2	IDA		Human	PMID:11481335
Biological Process	GO:0035336	long-chain fatty-acyl-CoA metabolic process	Dgat2	IDA		Mouse	MGI:MGI:2151970|PMID:11481335
Biological Process	GO:0034383	low-density lipoprotein particle clearance	Dgat2	IMP		Mouse	MGI:MGI:3784112|PMID:18175806
Biological Process	GO:0006640	monoacylglycerol biosynthetic process	DGAT2	IDA		Human	PMID:28420705
Biological Process	GO:0046322	negative regulation of fatty acid oxidation	Dgat2	IMP		Rat	PMID:17526931|RGD:10400884
Biological Process	GO:0045722	positive regulation of gluconeogenesis	Dgat2	IMP		Rat	PMID:17526931|RGD:10400884
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	Dgat2	IMP		Rat	PMID:17526931|RGD:10400884
Biological Process	GO:0090181	regulation of cholesterol metabolic process	Dgat2	IMP		Rat	PMID:17526931|RGD:10400884
Biological Process	GO:0050746	regulation of lipoprotein metabolic process	Dgat2	IMP		Rat	PMID:17526931|RGD:10400884
Biological Process	GO:0097006	regulation of plasma lipoprotein particle levels	Dgat2	IMP		Mouse	MGI:MGI:3778742|PMID:18252207
Biological Process	GO:1905897	regulation of response to endoplasmic reticulum stress	dgat2	IGI	ZFIN:ZDB-MRPHLNO-170719-1,ZFIN:ZDB-MRPHLNO-170719-2	Zfish	PMID:28027591
Biological Process	GO:0061959	response to (R)-carnitine	dgat2	IEP		Zfish	PMID:28102299
Biological Process	GO:0019432	triglyceride biosynthetic process	DGAT2	IDA		Human	PMID:11481335
Biological Process	GO:0019432	triglyceride biosynthetic process	DGAT2	IDA		Human	PMID:27184406
Biological Process	GO:0019432	triglyceride biosynthetic process	Dgat2	IMP		Mouse	PMID:21680734
Biological Process	GO:0019432	triglyceride biosynthetic process	Dgat2	IMP	MGI:MGI:3037903	Mouse	PMID:14668353
Biological Process	GO:0019432	triglyceride biosynthetic process	Dgat2	IDA		Mouse	PMID:11481335
Biological Process	GO:0019432	triglyceride biosynthetic process	Dgat2	IDA		Mouse	PMID:12077311

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern