Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DHCR24
  • Mouse genes Dhcr24
  • Rat genes Dhcr24
  • Zfish genes dhcr24
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dhcr24

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000246	delta24(24-1) sterol reductase activity	DHCR24	IMP		Human	PMID:11519011
Molecular Function	GO:0050614	delta24-sterol reductase activity	DHCR24	EXP		Human	PMID:11519011
Molecular Function	GO:0019899	enzyme binding	DHCR24	IPI	UniProtKB:Q00987	Human	PMID:15577914
Molecular Function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	DHCR24	IDA		Human	PMID:11519011
Molecular Function	GO:0042605	peptide antigen binding	DHCR24	IPI	UniProtKB:P04637	Human	PMID:15577914
Molecular Function	GO:0005515	protein binding	DHCR24	IPI	UniProtKB:Q9UBM7	Human	PMID:25637936
Cellular Component	GO:0005737	cytoplasm	Dhcr24	IDA		Rat	PMID:17210742|RGD:2316898
Cellular Component	GO:0005737	cytoplasm	Dhcr24	IDA		Rat	PMID:18468884|RGD:2316895
Cellular Component	GO:0005856	cytoskeleton	Dhcr24	IDA		Rat	PMID:17210742|RGD:2316898
Cellular Component	GO:0005829	cytosol	Dhcr24	IDA		Rat	PMID:17210742|RGD:2316898
Cellular Component	GO:0005783	endoplasmic reticulum	DHCR24	IDA		Human	PMID:11007892
Cellular Component	GO:0016020	membrane	DHCR24	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Dhcr24	IDA		Rat	PMID:17210742|RGD:2316898
Cellular Component	GO:0005634	nucleus	DHCR24	IDA		Human	PMID:15577914
Cellular Component	GO:0005634	nucleus	Dhcr24	IDA		Rat	PMID:17210742|RGD:2316898
Cellular Component	GO:0005634	nucleus	Dhcr24	IDA		Rat	PMID:18468884|RGD:2316895
Biological Process	GO:0042987	amyloid precursor protein catabolic process	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:16407971
Biological Process	GO:0006695	cholesterol biosynthetic process	DHCR24	IMP		Human	PMID:11519011
Biological Process	GO:0006695	cholesterol biosynthetic process	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:16321981
Biological Process	GO:0006695	cholesterol biosynthetic process	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:16513830
Biological Process	GO:0006695	cholesterol biosynthetic process	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:14684813
Biological Process	GO:0033489	cholesterol biosynthetic process via desmosterol	DHCR24	IMP		Human	PMID:11519011
Biological Process	GO:0008203	cholesterol metabolic process	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:16407971
Biological Process	GO:0030539	male genitalia development	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:14684813
Biological Process	GO:0061024	membrane organization	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:16407971
Biological Process	GO:0043066	negative regulation of apoptotic process	DHCR24	IDA		Human	PMID:15688385
Biological Process	GO:0008285	negative regulation of cell population proliferation	Dhcr24	IMP		Rat	PMID:15577914|RGD:1600898
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	DHCR24	IDA		Human	PMID:11007892
Biological Process	GO:0031639	plasminogen activation	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:16407971
Biological Process	GO:0008104	protein localization	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:16513830
Biological Process	GO:0008104	protein localization	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:16407971
Biological Process	GO:0007265	Ras protein signal transduction	Dhcr24	IMP		Rat	PMID:15577914|RGD:1600898
Biological Process	GO:0009725	response to hormone	Dhcr24	IEP		Rat	PMID:17210742|RGD:2316898
Biological Process	GO:0006979	response to oxidative stress	DHCR24	IEP		Human	PMID:11007892
Biological Process	GO:0043588	skin development	Dhcr24	IMP		Mouse	MGI:MGI:3619481|PMID:16410790
Biological Process	GO:0008202	steroid metabolic process	Dhcr24	IMP		Rat	PMID:17210742|RGD:2316898
Biological Process	GO:0016125	sterol metabolic process	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:14684813
Biological Process	GO:0009888	tissue development	DHCR24	IMP		Human	PMID:12457401
Biological Process	GO:0009888	tissue development	Dhcr24	IMP	MGI:MGI:3027024	Mouse	PMID:14684813

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern