Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DHCR7
  • Mouse genes Dhcr7
  • Rat genes Dhcr7
  • Zfish genes dhcr7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dhcr7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047598	7-dehydrocholesterol reductase activity	DHCR7	EXP		Human	PMID:9465114
Molecular Function	GO:0047598	7-dehydrocholesterol reductase activity	DHCR7	IDA		Human	PMID:9465114
Molecular Function	GO:0047598	7-dehydrocholesterol reductase activity	Dhcr7	IDA		Mouse	PMID:11792727
Molecular Function	GO:0047598	7-dehydrocholesterol reductase activity	Dhcr7	IMP		Rat	PMID:10666310|RGD:2316916
Molecular Function	GO:0047598	7-dehydrocholesterol reductase activity	Dhcr7	IMP		Rat	PMID:9831636|RGD:2316918
Molecular Function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	dhcr7	IDA		Zfish	PMID:28357621
Molecular Function	GO:0005515	protein binding	DHCR7	IPI	UniProtKB:Q15392	Human	PMID:25637936
Molecular Function	GO:0005515	protein binding	DHCR7	IPI	UniProtKB:Q9BVK8	Human	PMID:32694168
Cellular Component	GO:0005783	endoplasmic reticulum	DHCR7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	DHCR7	IDA		Human	PMID:9878250
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Dhcr7	IDA		Rat	PMID:10666310|RGD:2316916
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Dhcr7	IDA		Rat	PMID:9831636|RGD:2316918
Cellular Component	GO:0016020	membrane	DHCR7	HDA		Human	PMID:19946888
Cellular Component	GO:0005640	nuclear outer membrane	DHCR7	IDA		Human	PMID:9878250
Biological Process	GO:0001568	blood vessel development	Dhcr7	IMP	MGI:MGI:2387406	Mouse	PMID:15005800
Biological Process	GO:0006695	cholesterol biosynthetic process	DHCR7	IMP		Human	PMID:9465114
Biological Process	GO:0006695	cholesterol biosynthetic process	Dhcr7	IDA		Rat	PMID:10329655|RGD:632010
Biological Process	GO:0006695	cholesterol biosynthetic process	Dhcr7	IMP		Rat	PMID:9831636|RGD:2316918
Biological Process	GO:0006695	cholesterol biosynthetic process	dhcr7	IMP	ZFIN:ZDB-MRPHLNO-210628-2	Zfish	PMID:33079236
Biological Process	GO:0030324	lung development	Dhcr7	IMP	MGI:MGI:2387406	Mouse	PMID:15005800
Biological Process	GO:0060487	lung epithelial cell differentiation	Dhcr7	IMP	MGI:MGI:2387406	Mouse	PMID:15005800
Biological Process	GO:0035264	multicellular organism growth	Dhcr7	IMP	MGI:MGI:2387406	Mouse	PMID:15005800
Biological Process	GO:0009791	post-embryonic development	Dhcr7	IMP	MGI:MGI:2387406	Mouse	PMID:15005800
Biological Process	GO:0042127	regulation of cell population proliferation	Dhcr7	IMP	MGI:MGI:2387406	Mouse	PMID:15005800
Biological Process	GO:0045540	regulation of cholesterol biosynthetic process	Dhcr7	IDA		Rat	PMID:10329655|RGD:632010
Biological Process	GO:0016126	sterol biosynthetic process	Dhcr7	IMP	MGI:MGI:2387406	Mouse	PMID:15005800

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern