Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DHFR,DHFR2,DHFRP1
  • Mouse genes Dhfr
  • Rat genes Dhfr
  • Zfish genes dhfr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dhfr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004146	dihydrofolate reductase activity	DHFR	IDA		Human	PMID:12096917
Molecular Function	GO:0004146	dihydrofolate reductase activity	DHFR	IDA		Human	PMID:21876184
Molecular Function	GO:0004146	dihydrofolate reductase activity	DHFR	IDA		Human	PMID:2303423
Molecular Function	GO:0004146	dihydrofolate reductase activity	DHFR	IDA		Human	PMID:23707606
Molecular Function	GO:0004146	dihydrofolate reductase activity	DHFR2	IMP		Human	PMID:21876188
Molecular Function	GO:0004146	dihydrofolate reductase activity	Dhfr	IDA		Mouse	MGI:MGI:5648652|PMID:25980602
Molecular Function	GO:0004146	dihydrofolate reductase activity	Dhfr	IDA		Mouse	PMID:360074
Molecular Function	GO:0004146	dihydrofolate reductase activity	Dhfr	IDA		Mouse	PMID:14667810
Molecular Function	GO:0004146	dihydrofolate reductase activity	Dhfr	IDA		Rat	PMID:11502523|RGD:1298877
Molecular Function	GO:0004146	dihydrofolate reductase activity	Dhfr	IDA		Rat	PMID:20424322|RGD:10054082
Molecular Function	GO:0004146	dihydrofolate reductase activity	Dhfr	IDA		Rat	PMID:25980602|RGD:11343487
Molecular Function	GO:0004146	dihydrofolate reductase activity	Dhfr	IDA		Rat	PMID:3970530|RGD:2300196
Molecular Function	GO:0004146	dihydrofolate reductase activity	Dhfr	IMP		Rat	PMID:6162551|RGD:2300194
Molecular Function	GO:0004146	dihydrofolate reductase activity	dhfr	IDA		Zfish	PMID:18056255
Molecular Function	GO:0051871	dihydrofolic acid binding	Dhfr	IDA		Rat	PMID:3970530|RGD:2300196
Molecular Function	GO:0005542	folic acid binding	DHFR	IDA		Human	PMID:2303423
Molecular Function	GO:0003729	mRNA binding	DHFR	IDA		Human	PMID:21876184
Molecular Function	GO:0003729	mRNA binding	DHFR2	IDA		Human	PMID:21876184
Molecular Function	GO:0000900	mRNA regulatory element binding translation repressor activity	DHFR	IDA		Human	PMID:8490020
Molecular Function	GO:0050661	NADP binding	Dhfr	IDA		Rat	PMID:3970530|RGD:2300196
Molecular Function	GO:0070402	NADPH binding	DHFR	IDA		Human	PMID:2303423
Molecular Function	GO:1990825	sequence-specific mRNA binding	DHFR	IDA		Human	PMID:8490020
Cellular Component	GO:0005737	cytoplasm	Dhfr	IDA		Mouse	MGI:MGI:5648652|PMID:25980602
Cellular Component	GO:0005737	cytoplasm	Dhfr	IDA		Rat	PMID:25980602|RGD:11343487
Cellular Component	GO:0005743	mitochondrial inner membrane	DHFR2	IMP		Human	PMID:21876188
Cellular Component	GO:0005759	mitochondrial matrix	DHFR2	IMP		Human	PMID:21876188
Cellular Component	GO:0005739	mitochondrion	DHFR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	DHFR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	DHFR2	IDA		Human	PMID:21876184
Cellular Component	GO:0005739	mitochondrion	Dhfr	IDA		Mouse	MGI:MGI:5648652|PMID:25980602
Cellular Component	GO:0005739	mitochondrion	Dhfr	IDA		Rat	PMID:25980602|RGD:11343487
Cellular Component	GO:0005634	nucleus	Dhfr	IDA		Mouse	PMID:19513116
Biological Process	GO:0031103	axon regeneration	Dhfr	IMP		Rat	PMID:20424322|RGD:10054082
Biological Process	GO:0003232	bulbus arteriosus development	dhfr	IMP	ZFIN:ZDB-MRPHLNO-070920-3,ZFIN:ZDB-MRPHLNO-150609-1	Zfish	PMID:22113051
Biological Process	GO:0046452	dihydrofolate metabolic process	DHFR	IDA		Human	PMID:2303423
Biological Process	GO:0046452	dihydrofolate metabolic process	DHFR	IDA		Human	PMID:23707606
Biological Process	GO:0046452	dihydrofolate metabolic process	Dhfr	IDA		Rat	PMID:11502523|RGD:1298877
Biological Process	GO:0046452	dihydrofolate metabolic process	Dhfr	IDA		Rat	PMID:3970530|RGD:2300196
Biological Process	GO:0048598	embryonic morphogenesis	dhfr	IMP	ZFIN:ZDB-MRPHLNO-120813-3	Zfish	PMID:22480165
Biological Process	GO:0048598	embryonic morphogenesis	dhfr	IMP	ZFIN:ZDB-MRPHLNO-070920-3	Zfish	PMID:22480165
Biological Process	GO:0046655	folic acid metabolic process	Dhfr	IDA		Rat	PMID:20424322|RGD:10054082
Biological Process	GO:0046655	folic acid metabolic process	dhfr	IMP	ZFIN:ZDB-MRPHLNO-070920-3	Zfish	PMID:22480165
Biological Process	GO:0046655	folic acid metabolic process	dhfr	IMP	ZFIN:ZDB-MRPHLNO-120813-3	Zfish	PMID:22480165
Biological Process	GO:0060047	heart contraction	dhfr	IMP	ZFIN:ZDB-MRPHLNO-070920-3	Zfish	PMID:17637246
Biological Process	GO:0001947	heart looping	dhfr	IMP	ZFIN:ZDB-MRPHLNO-070920-3,ZFIN:ZDB-MRPHLNO-150609-1	Zfish	PMID:22113051
Biological Process	GO:0001947	heart looping	dhfr	IMP	ZFIN:ZDB-MRPHLNO-120813-3	Zfish	PMID:22480165
Biological Process	GO:0003007	heart morphogenesis	dhfr	IGI	ZFIN:ZDB-MRPHLNO-070920-3	Zfish	PMID:17637246
Biological Process	GO:0017148	negative regulation of translation	DHFR	IDA		Human	PMID:8490020
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	Dhfr	IMP		Mouse	MGI:MGI:5645206|PMID:19666465
Biological Process	GO:2000121	regulation of removal of superoxide radicals	Dhfr	IMP		Mouse	MGI:MGI:5645206|PMID:19666465
Biological Process	GO:0035094	response to nicotine	Dhfr	IEP		Rat	PMID:15983034|RGD:1578502
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	DHFR	IMP		Human	PMID:23707606
Biological Process	GO:0006729	tetrahydrobiopterin biosynthetic process	Dhfr	IMP		Mouse	MGI:MGI:5645206|PMID:19666465
Biological Process	GO:0046654	tetrahydrofolate biosynthetic process	DHFR	IDA		Human	PMID:2303423
Biological Process	GO:0046654	tetrahydrofolate biosynthetic process	Dhfr	IDA		Rat	PMID:11502523|RGD:1298877
Biological Process	GO:0035999	tetrahydrofolate interconversion	Dhfr	IDA		Mouse	PMID:360074
Biological Process	GO:0046653	tetrahydrofolate metabolic process	DHFR	IDA		Human	PMID:12096917
Biological Process	GO:0046653	tetrahydrofolate metabolic process	DHFR	IDA		Human	PMID:21876184
Biological Process	GO:0046653	tetrahydrofolate metabolic process	DHFR2	IDA		Human	PMID:21876184
Biological Process	GO:0046105	thymidine biosynthetic process	DHFR2	IDA		Human	PMID:21876188

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern