Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DHODH
  • Mouse genes Dhodh
  • Rat genes Dhodh
  • Zfish genes dhodh
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dhodh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004151	dihydroorotase activity	Dhodh	IMP		Mouse	PMID:20413687
Molecular Function	GO:0004151	dihydroorotase activity	Dhodh	IMP		Mouse	PMID:33771897
Molecular Function	GO:0004152	dihydroorotate dehydrogenase activity	Dhodh	IMP		Mouse	PMID:20413687
Molecular Function	GO:0004152	dihydroorotate dehydrogenase activity	Dhodh	IMP		Mouse	PMID:6249586
Molecular Function	GO:0004152	dihydroorotate dehydrogenase activity	Dhodh	IDA		Rat	PMID:1313236|RGD:5132611
Molecular Function	GO:0004152	dihydroorotate dehydrogenase activity	Dhodh	IDA		Rat	PMID:15044733|RGD:2316233
Molecular Function	GO:0010181	FMN binding	Dhodh	IDA		Rat	PMID:9693067|RGD:5132598
Molecular Function	GO:0005515	protein binding	DHODH	IPI	UniProtKB:P49638	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DHODH	IPI	UniProtKB:Q6ZMZ0	Human	PMID:32296183
Molecular Function	GO:0048038	quinone binding	Dhodh	IPI	CHEBI:575568|CHEBI:77103	Rat	PMID:15044733|RGD:2316233
Molecular Function	GO:0048039	ubiquinone binding	Dhodh	IDA		Rat	PMID:9179295|RGD:5132597
Cellular Component	GO:0005829	cytosol	DHODH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005743	mitochondrial inner membrane	Dhodh	IDA		Rat	PMID:10727948|RGD:2316234
Cellular Component	GO:0005739	mitochondrion	DHODH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Dhodh	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Dhodh	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043025	neuronal cell body	Dhodh	IDA		Rat	PMID:20544541|RGD:5132596
Cellular Component	GO:0005654	nucleoplasm	DHODH	IDA		Human	GO_REF:0000052
Biological Process	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	Dhodh	IDA		Rat	PMID:1476792|RGD:5132591
Biological Process	GO:0044205	'de novo' UMP biosynthetic process	Dhodh	IMP		Mouse	PMID:6249586
Biological Process	GO:0044205	'de novo' UMP biosynthetic process	Dhodh	IMP		Mouse	PMID:30449682
Biological Process	GO:0007565	female pregnancy	Dhodh	IEP		Rat	PMID:1476792|RGD:5132591
Biological Process	GO:0007595	lactation	Dhodh	IEP		Rat	PMID:1476792|RGD:5132591
Biological Process	GO:0043065	positive regulation of apoptotic process	Dhodh	IMP		Rat	PMID:15182735|RGD:2316231
Biological Process	GO:0090140	regulation of mitochondrial fission	Dhodh	IMP		Rat	PMID:16120318|RGD:2316230
Biological Process	GO:0031000	response to caffeine	Dhodh	IEP		Rat	PMID:6149265|RGD:2303533
Biological Process	GO:1903576	response to L-arginine	Dhodh	IEP		Rat	PMID:6167833|RGD:11040444
Biological Process	GO:0014070	response to organic cyclic compound	Dhodh	IEP		Rat	PMID:9879809|RGD:5132601
Biological Process	GO:0042594	response to starvation	Dhodh	IEP		Rat	PMID:6331524|RGD:5132618
Biological Process	GO:0009410	response to xenobiotic stimulus	Dhodh	IEP		Rat	PMID:9123312|RGD:5132603
Biological Process	GO:0006225	UDP biosynthetic process	Dhodh	IMP		Mouse	PMID:6249586
Biological Process	GO:0006225	UDP biosynthetic process	Dhodh	IMP		Mouse	PMID:30449682

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern