Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DIO3
  • Mouse genes Dio3
  • Rat genes Dio3
  • Zfish genes dio3a,dio3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dio3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	Dio3	IMP	MGI:MGI:2664293	Mouse	PMID:12399446
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	Dio3	IMP	MGI:MGI:2664293	Mouse	PMID:16410833
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	dio3a	IDA		Zfish	PMID:25004091
Molecular Function	GO:0033798	thyroxine 5-deiodinase activity	DIO3	IDA		Human	PMID:18566113
Molecular Function	GO:0033798	thyroxine 5-deiodinase activity	Dio3	IDA		Mouse	MGI:MGI:3691903|PMID:12586753
Molecular Function	GO:0033798	thyroxine 5-deiodinase activity	Dio3	IDA		Mouse	PMID:20203194
Molecular Function	GO:0033798	thyroxine 5-deiodinase activity	Dio3	IDA		Mouse	PMID:25002520
Molecular Function	GO:0033798	thyroxine 5-deiodinase activity	dio3b	IDA		Zfish	PMID:25004091
Molecular Function	GO:0033798	thyroxine 5-deiodinase activity	dio3b	IDA		Zfish	PMID:20403357
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	DIO3	IDA		Human	GO_REF:0000052
Biological Process	GO:0006915	apoptotic process	Dio3	IMP	MGI:MGI:2664293	Mouse	PMID:20203194
Biological Process	GO:0070342	brown fat cell proliferation	Dio3	IEP		Rat	PMID:17510246|RGD:2303418
Biological Process	GO:0043009	chordate embryonic development	dio3b	IMP	ZFIN:ZDB-MRPHLNO-130306-3	Zfish	PMID:24467742
Biological Process	GO:0043009	chordate embryonic development	dio3b	IMP	ZFIN:ZDB-MRPHLNO-130306-3	Zfish	PMID:23603432
Biological Process	GO:0043009	chordate embryonic development	dio3a	IMP	ZFIN:ZDB-MRPHLNO-140429-2	Zfish	PMID:24467742
Biological Process	GO:0001889	liver development	dio3b	IMP	ZFIN:ZDB-MRPHLNO-130306-3	Zfish	PMID:24467742
Biological Process	GO:0060037	pharyngeal system development	dio3b	IMP	ZFIN:ZDB-MRPHLNO-130306-3	Zfish	PMID:23165295
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Dio3	IMP	MGI:MGI:2664293	Mouse	PMID:16410833
Biological Process	GO:0061074	regulation of neural retina development	dio3b	IMP	ZFIN:ZDB-MRPHLNO-130306-3	Zfish	PMID:26802877
Biological Process	GO:0001666	response to hypoxia	Dio3	IEP		Rat	PMID:18259611|RGD:2303417
Biological Process	GO:0097474	retinal cone cell apoptotic process	Dio3	IMP		Mouse	PMID:20203194
Biological Process	GO:0046549	retinal cone cell development	Dio3	IMP		Mouse	PMID:20203194
Biological Process	GO:0046549	retinal cone cell development	Dio3	IMP	MGI:MGI:2664293	Mouse	PMID:20203194
Biological Process	GO:0048794	swim bladder development	dio3b	IMP	ZFIN:ZDB-MRPHLNO-130306-3	Zfish	PMID:24467742
Biological Process	GO:0036269	swimming behavior	dio3b	IMP	ZFIN:ZDB-MRPHLNO-130306-3	Zfish	PMID:24467742
Biological Process	GO:0042404	thyroid hormone catabolic process	Dio3	IDA		Mouse	PMID:20203194
Biological Process	GO:0042404	thyroid hormone catabolic process	Dio3	IDA		Mouse	PMID:25002520
Biological Process	GO:0042404	thyroid hormone catabolic process	Dio3	IMP	MGI:MGI:2664293	Mouse	PMID:16410833
Biological Process	GO:0042403	thyroid hormone metabolic process	DIO3	IGI	UniProtKB:P36021	Human	PMID:26305885

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern