Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Dkk1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DKK1
- Mouse genes Dkk1
- Rat genes Dkk1
- Zfish genes dkk1a,dkk1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dkk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0039706	co-receptor binding	DKK1	IPI	UniProtKB:O75197	Human	PMID:11433302
Molecular Function	GO:0039706	co-receptor binding	DKK1	IPI	UniProtKB:O75581	Human	PMID:11433302
Molecular Function	GO:0039706	co-receptor binding	DKK1	IPI	UniProtKB:O75581	Human	PMID:20093360
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	DKK1	IDA		Human	PMID:16263759
Molecular Function	GO:0005515	protein binding	DKK1	IPI	UniProtKB:O75581	Human	PMID:11448771
Molecular Function	GO:0005515	protein binding	DKK1	IPI	UniProtKB:Q99750	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	DKK1	IPI	UniProtKB:Q96MU8	Human	PMID:17804805
Molecular Function	GO:0005515	protein binding	DKK1	IPI	UniProtKB:Q99750	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	DKK1	IPI	UniProtKB:O75581	Human	PMID:21944579
Molecular Function	GO:0005515	protein binding	DKK1	IPI	UniProtKB:O75581	Human	PMID:21984209
Molecular Function	GO:0005515	protein binding	DKK1	IPI	UniProtKB:O75581	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	DKK1	IPI	UniProtKB:Q99750	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Dkk1	IPI	PR:Q8K1S7	Mouse	PMID:16126904
Molecular Function	GO:0005515	protein binding	Dkk1	IPI	PR:O88572	Mouse	PMID:16126904
Molecular Function	GO:0005515	protein binding	dkk1b	IPI	UniProtKB:Q90Z52	Zfish	PMID:17322405
Molecular Function	GO:0048019	receptor antagonist activity	DKK1	IDA		Human	PMID:20723538
Cellular Component	GO:0005737	cytoplasm	dkk1b	IDA		Zfish	PMID:17322405
Cellular Component	GO:0005576	extracellular region	dkk1b	IDA		Zfish	PMID:17322405
Cellular Component	GO:0005615	extracellular space	DKK1	IDA		Human	PMID:11448771
Cellular Component	GO:0005615	extracellular space	DKK1	IDA		Human	PMID:11742004
Cellular Component	GO:0005615	extracellular space	Dkk1	IDA		Rat	PMID:22009597\|RGD:6907378
Cellular Component	GO:0005886	plasma membrane	DKK1	IDA		Human	PMID:16263759
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dkk1	IGI	MGI:MGI:108078	Mouse	PMID:18257070
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dkk1	IMP	MGI:MGI:2387760	Mouse	PMID:18403408
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dkk1	IGI	MGI:MGI:98955	Mouse	PMID:18403408
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dkk1	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0043697	cell dedifferentiation	dkk1b	IGI	ZFIN:ZDB-GENE-040426-1810,ZFIN:ZDB-GENE-980526-90	Zfish	PMID:23000964
Biological Process	GO:0042074	cell migration involved in gastrulation	dkk1b	IMP	ZFIN:ZDB-MRPHLNO-070604-1	Zfish	PMID:17322405
Biological Process	GO:0042074	cell migration involved in gastrulation	dkk1b	IMP	ZFIN:ZDB-MRPHLNO-070604-2	Zfish	PMID:17322405
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	Dkk1	IMP	MGI:MGI:2387760	Mouse	PMID:18403408
Biological Process	GO:0007398	ectoderm development	dkk1b	IGI	ZFIN:ZDB-GENE-990630-10	Zfish	PMID:10625541
Biological Process	GO:0030326	embryonic limb morphogenesis	Dkk1	IGI	MGI:MGI:95389	Mouse	PMID:15242796
Biological Process	GO:0030326	embryonic limb morphogenesis	Dkk1	IGI	MGI:MGI:98961	Mouse	PMID:15242796
Biological Process	GO:0003197	endocardial cushion development	dkk1b	IMP		Zfish	PMID:14534590
Biological Process	GO:0007492	endoderm development	Dkk1	IMP	MGI:MGI:2387760	Mouse	PMID:18403408
Biological Process	GO:0001706	endoderm formation	Dkk1	IDA		Mouse	PMID:18462699
Biological Process	GO:0060325	face morphogenesis	Dkk1	IMP		Mouse	PMID:17699607
Biological Process	GO:0030900	forebrain development	Dkk1	IGI	MGI:MGI:95841	Mouse	PMID:17127040
Biological Process	GO:0030900	forebrain development	dkk1b	IGI	ZFIN:ZDB-GENO-980202-228	Zfish	PMID:10625541
Biological Process	GO:0021879	forebrain neuron differentiation	dkk1b	IMP		Zfish	PMID:18799544
Biological Process	GO:0001942	hair follicle development	Dkk1	IDA		Mouse	PMID:16682203
Biological Process	GO:0060323	head morphogenesis	Dkk1	IGI	MGI:MGI:98955	Mouse	PMID:18403408
Biological Process	GO:0061011	hepatic duct development	dkk1b	IGI	ZFIN:ZDB-GENO-130805-3	Zfish	PMID:22313811
Biological Process	GO:0007611	learning or memory	Dkk1	IDA		Mouse	MGI:MGI:5897547\|PMID:23164821
Biological Process	GO:0060173	limb development	Dkk1	IMP		Mouse	MGI:MGI:3803396\|PMID:18505822
Biological Process	GO:0001889	liver development	dkk1b	IGI	ZFIN:ZDB-GENO-130809-1	Zfish	PMID:22313811
Biological Process	GO:0001889	liver development	dkk1b	IGI	ZFIN:ZDB-GENO-130805-3	Zfish	PMID:22313811
Biological Process	GO:0001707	mesoderm formation	Dkk1	IDA		Mouse	PMID:18462699
Biological Process	GO:0061743	motor learning	Dkk1	IDA		Mouse	MGI:MGI:5692401\|PMID:25318560
Biological Process	GO:0043066	negative regulation of apoptotic process	Dkk1	IDA		Mouse	MGI:MGI:5883198\|PMID:26206087
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	Dkk1	IDA		Mouse	PMID:19850029
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IGI	UniProtKB:P27467	Human	PMID:18166153
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IDA		Human	PMID:11433302
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IDA		Human	PMID:11448771
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IDA		Human	PMID:11742004
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IDA		Human	PMID:12857724
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IDA		Human	PMID:17804805
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IDA		Human	PMID:18044981
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IDA		Human	PMID:20039315
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IDA		Human	PMID:20093360
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IDA		Human	PMID:22902902
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK1	IGI	RNAcentral:URS00001E2DBC_9606	Human	PMID:27846906
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IDA		Mouse	MGI:MGI:5705223\|PMID:17027228
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IDA		Mouse	MGI:MGI:5692401\|PMID:25318560
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IGI	UniProtKB:O00755,UniProtKB:P02649	Mouse	MGI:MGI:5825432\|PMID:16805831
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:17360443
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:20383322
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IGI	MGI:MGI:2442252	Mouse	PMID:20383322
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IGI	MGI:MGI:108078	Mouse	PMID:18257070
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IGI	MGI:MGI:892014	Mouse	PMID:18257070
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IGI	MGI:MGI:98953	Mouse	PMID:15143170
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:17128274
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:17804636
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IMP	MGI:MGI:2387760	Mouse	PMID:18403408
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Dkk1	IGI	MGI:MGI:98955	Mouse	PMID:18403408
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	dkk1b	IGI	ZFIN:ZDB-GENE-120807-2,ZFIN:ZDB-MRPHLNO-120725-2	Zfish	PMID:22669824
Biological Process	GO:1901296	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	DKK1	IDA		Human	PMID:20559569
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	DKK1	IDA		Human	PMID:20559569
Biological Process	GO:0042662	negative regulation of mesodermal cell fate specification	DKK1	IDA		Human	PMID:20559569
Biological Process	GO:0010977	negative regulation of neuron projection development	Dkk1	IDA		Mouse	MGI:MGI:6274944\|PMID:29643768
Biological Process	GO:0030279	negative regulation of ossification	Dkk1	IMP		Mouse	MGI:MGI:3803396\|PMID:18505822
Biological Process	GO:0030279	negative regulation of ossification	Dkk1	IMP		Rat	PMID:21773994\|RGD:6907379
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	DKK1	IDA		Human	PMID:20559569
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	DKK1	IDA		Human	PMID:20723538
Biological Process	GO:1905607	negative regulation of presynapse assembly	Dkk1	IDA		Mouse	MGI:MGI:6274944\|PMID:29643768
Biological Process	GO:0032091	negative regulation of protein binding	DKK1	IDA		Human	PMID:20093360
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DKK1	IDA		Human	PMID:20723538
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dkk1	IDA		Mouse	MGI:MGI:4887541\|PMID:19850024
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dkk1	IDA		Mouse	PMID:17128274
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	DKK1	IDA		Human	PMID:15020244
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	DKK1	IDA		Human	PMID:22615920
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:19850029
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:17699607
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:20160075
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:16126904
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:18462699
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	dkk1b	IGI	ZFIN:ZDB-GENE-990415-279	Zfish	PMID:10625541
Biological Process	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	DKK1	IPI	UniProtKB:O75581	Human	PMID:11433302
Biological Process	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	DKK1	IDA		Human	PMID:11448771
Biological Process	GO:1904723	negative regulation of Wnt-Frizzled-LRP5/6 complex assembly	DKK1	IDA		Human	PMID:20093360
Biological Process	GO:0048884	neuromast development	dkk1a	IMP	ZFIN:ZDB-GENO-140121-8	Zfish	PMID:23891113
Biological Process	GO:0030903	notochord development	dkk1b	IGI	ZFIN:ZDB-GENO-980202-228	Zfish	PMID:10625541
Biological Process	GO:0010628	positive regulation of gene expression	DKK1	IGI	ComplexPortal:CPX-1120\|ComplexPortal:CPX-1134\|UniProtKB:P05067:PRO_0000000092\|UniProtKB:P05067:PRO_0000000093	Human	PMID:23164821
Biological Process	GO:0010628	positive regulation of gene expression	DKK1	IGI	ComplexPortal:CPX-1120\|ComplexPortal:CPX-1134\|UniProtKB:P08592:PRO_0000000166\|UniProtKB:P08592:PRO_0000000167	Human	PMID:23164821
Biological Process	GO:0010628	positive regulation of gene expression	Dkk1	IDA		Mouse	MGI:MGI:5897547\|PMID:23164821
Biological Process	GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	Dkk1	IDA		Mouse	MGI:MGI:3835736\|PMID:18297060
Biological Process	GO:0043507	positive regulation of JUN kinase activity	DKK1	IDA		Human	PMID:23164821
Biological Process	GO:1904958	positive regulation of midbrain dopaminergic neuron differentiation	Dkk1	IMP		Mouse	MGI:MGI:4948425\|PMID:21347250
Biological Process	GO:1901216	positive regulation of neuron death	Dkk1	IGI	ComplexPortal:CPX-1120\|ComplexPortal:CPX-1134\|UniProtKB:P05067:PRO_0000000092\|UniProtKB:P05067:PRO_0000000093	Rat	PMID:23164821\|RGD:12903240
Biological Process	GO:1902949	positive regulation of tau-protein kinase activity	Dkk1	IDA		Mouse	MGI:MGI:5897547\|PMID:23164821
Biological Process	GO:0048919	posterior lateral line neuromast development	dkk1b	IMP	ZFIN:ZDB-GENO-090206-1	Zfish	PMID:19000839
Biological Process	GO:0030334	regulation of cell migration	dkk1b	IGI	ZFIN:ZDB-GENE-011119-1	Zfish	PMID:17322405
Biological Process	GO:0042663	regulation of endodermal cell fate specification	DKK1	IDA		Human	PMID:20559569
Biological Process	GO:0002090	regulation of receptor internalization	DKK1	IDA		Human	PMID:17804805
Biological Process	GO:0050807	regulation of synapse organization	Dkk1	IDA		Mouse	MGI:MGI:5692401\|PMID:25318560
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	Dkk1	IDA		Mouse	MGI:MGI:5692401\|PMID:25318560
Biological Process	GO:0030111	regulation of Wnt signaling pathway	Dkk1	IMP	MGI:MGI:2387760	Mouse	PMID:17127040
Biological Process	GO:0032526	response to retinoic acid	Dkk1	IDA		Mouse	PMID:17064353
Biological Process	GO:0070654	sensory epithelium regeneration	dkk1a	IEP		Zfish	PMID:21911394
Biological Process	GO:0070654	sensory epithelium regeneration	dkk1b	IGI	ZFIN:ZDB-GENE-040426-1810,ZFIN:ZDB-GENE-980526-90	Zfish	PMID:23000964
Biological Process	GO:0016055	Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:18462699
Biological Process	GO:0016055	Wnt signaling pathway	Dkk1	IDA		Mouse	PMID:20160075
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	Dkk1	IGI	MGI:MGI:108078	Mouse	PMID:18257070
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	Dkk1	IGI	MGI:MGI:892014	Mouse	PMID:18257070

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.