Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DKK3
  • Mouse genes Dkk3
  • Rat genes Dkk3
  • Zfish genes dkk3a,dkk3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dkk3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	DKK3	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DKK3	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DKK3	IPI	UniProtKB:O75190-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DKK3	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Cellular Component	GO:0005615	extracellular space	Dkk3	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Biological Process	GO:0030325	adrenal gland development	DKK3	IEP		Human	PMID:12844346
Biological Process	GO:0043010	camera-type eye development	dkk3b	IMP	ZFIN:ZDB-MRPHLNO-200806-9	Zfish	PMID:31934309
Biological Process	GO:0002088	lens development in camera-type eye	dkk3b	IMP	ZFIN:ZDB-MRPHLNO-200806-9	Zfish	PMID:31934309
Biological Process	GO:0032348	negative regulation of aldosterone biosynthetic process	DKK3	IDA		Human	PMID:16981135
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	DKK3	IDA		Human	PMID:12857724
Biological Process	GO:2000065	negative regulation of cortisol biosynthetic process	DKK3	IDA		Human	PMID:16981135
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	DKK3	IDA		Human	PMID:16981135
Biological Process	GO:0031647	regulation of protein stability	dkk3a	IMP	ZFIN:ZDB-MRPHLNO-100810-1	Zfish	PMID:21159776

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern