Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DLAT
  • Mouse genes Dlat
  • Rat genes Dlat
  • Zfish genes dlat
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dlat

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016407	acetyltransferase activity	Dlat	IMP		Mouse	PMID:27621431
Molecular Function	GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	DLAT	IDA		Human	PMID:9045657
Molecular Function	GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	Dlat	IDA		Rat	PMID:7487891|RGD:1599112
Molecular Function	GO:0042802	identical protein binding	DLAT	IPI	UniProtKB:P10515	Human	PMID:18184587
Molecular Function	GO:0042802	identical protein binding	DLAT	IPI	UniProtKB:P10515	Human	PMID:18184588
Molecular Function	GO:0005515	protein binding	DLAT	IPI	UniProtKB:Q15120	Human	PMID:15861126
Molecular Function	GO:0005515	protein binding	DLAT	IPI	UniProtKB:Q15120	Human	PMID:17683942
Molecular Function	GO:0005515	protein binding	DLAT	IPI	UniProtKB:P11177	Human	PMID:18206651
Molecular Function	GO:0005515	protein binding	DLAT	IPI	UniProtKB:Q9Y6E7	Human	PMID:25525879
Molecular Function	GO:0005515	protein binding	DLAT	IPI	UniProtKB:Q15120	Human	PMID:28514442
Molecular Function	GO:0034604	pyruvate dehydrogenase (NAD+) activity	DLAT	IDA		Human	PMID:9242632
Molecular Function	GO:0004738	pyruvate dehydrogenase activity	dlat	IMP	ZFIN:ZDB-GENO-001221-1	Zfish	PMID:15070761
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	DLAT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005759	mitochondrial matrix	Dlat	IDA		Mouse	PMID:9405644
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	DLAT	IPI		Human	PMID:19240034
Cellular Component	GO:0005739	mitochondrion	DLAT	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	DLAT	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Dlat	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Dlat	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Dlat	IDA		Rat	PMID:7487891|RGD:1599112
Cellular Component	GO:0005739	mitochondrion	Dlat	IDA		Rat	PMID:8431428|RGD:2313669
Cellular Component	GO:0043209	myelin sheath	Dlat	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	DLAT	IDA		Human	PMID:25525879
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	DLAT	IDA		Human	PMID:9242632
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	Dlat	IDA		Rat	PMID:7487891|RGD:1599112
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	DLAT	IDA		Human	PMID:24534072
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Dlat	IMP	MGI:MGI:2386703	Mouse	PMID:17314311
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Dlat	IMP		Mouse	PMID:27621431
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Dlat	IDA		Rat	PMID:7487891|RGD:1599112
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	dlat	IMP	ZFIN:ZDB-GENO-001221-1	Zfish	PMID:15070761
Biological Process	GO:0009583	detection of light stimulus	dlat	IMP	ZFIN:ZDB-GENO-001221-1	Zfish	PMID:9667001
Biological Process	GO:0009583	detection of light stimulus	dlat	IMP	ZFIN:ZDB-GENO-980202-295	Zfish	PMID:9667001
Biological Process	GO:0050908	detection of light stimulus involved in visual perception	dlat	IMP	ZFIN:ZDB-GENO-980202-295	Zfish	PMID:7479837
Biological Process	GO:0006090	pyruvate metabolic process	dlat	IMP	ZFIN:ZDB-GENO-160608-1	Zfish	PMID:23467562
Biological Process	GO:0006090	pyruvate metabolic process	dlat	IMP	ZFIN:ZDB-GENO-001221-1	Zfish	PMID:15070761
Biological Process	GO:0030431	sleep	Dlat	IEP		Rat	PMID:16923172|RGD:2313667

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern