Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DLC1
  • Mouse genes Dlc1
  • Rat genes Dlc1
  • Zfish genes dlc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dlc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	DLC1	IMP		Human	PMID:17888903
Molecular Function	GO:0005096	GTPase activator activity	DLC1	IDA		Human	PMID:17932950
Molecular Function	GO:0005096	GTPase activator activity	Dlc1	IDA		Rat	PMID:7835339|RGD:68218
Molecular Function	GO:0043274	phospholipase binding	Dlc1	IPI	RGD:3346	Rat	PMID:18157946|RGD:2304072
Molecular Function	GO:0005515	protein binding	DLC1	IPI	UniProtKB:Q03135	Human	PMID:16951145
Molecular Function	GO:0005515	protein binding	DLC1	IPI	UniProtKB:Q63HR2	Human	PMID:16951145
Molecular Function	GO:0005515	protein binding	DLC1	IPI	UniProtKB:P20936	Human	PMID:19151751
Molecular Function	GO:0005515	protein binding	DLC1	IPI	UniProtKB:P68104	Human	PMID:19158340
Molecular Function	GO:0005515	protein binding	DLC1	IPI	UniProtKB:P20936	Human	PMID:24412244
Molecular Function	GO:0005515	protein binding	DLC1	IPI	UniProtKB:Q923Q2	Human	PMID:32203420
Molecular Function	GO:0042169	SH2 domain binding	DLC1	IPI	UniProtKB:Q63HR2	Human	PMID:17190795
Molecular Function	GO:0042169	SH2 domain binding	DLC1	IPI	UniProtKB:Q68CZ2	Human	PMID:17190795
Molecular Function	GO:0042169	SH2 domain binding	DLC1	IPI	UniProtKB:Q8IZW8	Human	PMID:17190795
Molecular Function	GO:0042169	SH2 domain binding	DLC1	IPI	UniProtKB:Q9HBL0	Human	PMID:17190795
Molecular Function	GO:0017166	vinculin binding	Dlc1	IPI	RGD:1311217	Rat	PMID:15506980|RGD:1624304
Cellular Component	GO:0005884	actin filament	Dlc1	IDA		Rat	PMID:15506980|RGD:1624304
Cellular Component	GO:0005901	caveola	DLC1	IDA		Human	PMID:16951145
Cellular Component	GO:0030864	cortical actin cytoskeleton	DLC1	IDA		Human	PMID:19158340
Cellular Component	GO:0005737	cytoplasm	DLC1	IDA		Human	PMID:16951145
Cellular Component	GO:0005737	cytoplasm	DLC1	IDA		Human	PMID:17888903
Cellular Component	GO:0005829	cytosol	DLC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	DLC1	IDA		Human	PMID:19158340
Cellular Component	GO:0005783	endoplasmic reticulum	DLC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	DLC1	IDA		Human	PMID:16951145
Cellular Component	GO:0005925	focal adhesion	DLC1	IDA		Human	PMID:17190795
Cellular Component	GO:0005925	focal adhesion	Dlc1	IDA		Rat	PMID:15506980|RGD:1624304
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	DLC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045121	membrane raft	Dlc1	IDA		Rat	PMID:18157946|RGD:2304072
Cellular Component	GO:0005634	nucleus	DLC1	IDA		Human	PMID:17888903
Cellular Component	GO:0032587	ruffle membrane	DLC1	IDA		Human	PMID:19158340
Cellular Component	GO:0001725	stress fiber	Dlc1	IDA		Rat	PMID:15506980|RGD:1624304
Biological Process	GO:0030036	actin cytoskeleton organization	Dlc1	IMP	MGI:MGI:3529997	Mouse	PMID:15710412
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	DLC1	IDA		Human	PMID:17888903
Biological Process	GO:0007202	activation of phospholipase C activity	Dlc1	IDA		Rat	PMID:7835339|RGD:68218
Biological Process	GO:0006915	apoptotic process	DLC1	IDA		Human	PMID:17292327
Biological Process	GO:0032869	cellular response to insulin stimulus	Dlc1	IEP		Rat	PMID:16338927|RGD:2304073
Biological Process	GO:0007010	cytoskeleton organization	Dlc1	IDA		Rat	PMID:7835339|RGD:68218
Biological Process	GO:0048041	focal adhesion assembly	Dlc1	IMP	MGI:MGI:3529997	Mouse	PMID:15710412
Biological Process	GO:0030900	forebrain development	Dlc1	IMP	MGI:MGI:3529997	Mouse	PMID:15710412
Biological Process	GO:0003007	heart morphogenesis	Dlc1	IMP	MGI:MGI:3529997	Mouse	PMID:15710412
Biological Process	GO:0021575	hindbrain morphogenesis	Dlc1	IMP	MGI:MGI:3529997	Mouse	PMID:15710412
Biological Process	GO:0030336	negative regulation of cell migration	DLC1	IMP		Human	PMID:17292327
Biological Process	GO:0030336	negative regulation of cell migration	DLC1	IMP		Human	PMID:17888903
Biological Process	GO:0030336	negative regulation of cell migration	DLC1	IDA		Human	PMID:17932950
Biological Process	GO:0030336	negative regulation of cell migration	DLC1	IDA		Human	PMID:19158340
Biological Process	GO:0008285	negative regulation of cell population proliferation	DLC1	IDA		Human	PMID:12545165
Biological Process	GO:0008285	negative regulation of cell population proliferation	DLC1	IMP		Human	PMID:17292327
Biological Process	GO:0008285	negative regulation of cell population proliferation	DLC1	IDA		Human	PMID:17932950
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	DLC1	IDA		Human	PMID:19158340
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	DLC1	IMP		Human	PMID:16951145
Biological Process	GO:0051497	negative regulation of stress fiber assembly	DLC1	IDA		Human	PMID:17932950
Biological Process	GO:0001843	neural tube closure	Dlc1	IMP	MGI:MGI:3529997	Mouse	PMID:15710412
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	DLC1	IDA		Human	PMID:17888903
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	DLC1	IDA		Human	PMID:17292327
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	DLC1	IMP		Human	PMID:17292327
Biological Process	GO:0008360	regulation of cell shape	DLC1	IMP		Human	PMID:17292327

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern