Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DLD
  • Mouse genes Dld
  • Rat genes Dld
  • Zfish genes dldh
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dld

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	DLD	IDA		Human	PMID:16442803
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	Dld	IMP	MGI:MGI:2182403	Mouse	PMID:9405644
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	Dld	IDA		Rat	PMID:7487891|RGD:1599112
Molecular Function	GO:0004148	dihydrolipoyl dehydrogenase activity	Dld	IDA		Rat	PMID:8981046|RGD:2289895
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	Dld	IDA		Rat	PMID:3753688|RGD:2289893
Molecular Function	GO:0043544	lipoamide binding	Dld	IDA		Rat	PMID:8981046|RGD:2289895
Molecular Function	GO:0051287	NAD binding	Dld	IDA		Rat	PMID:3753688|RGD:2289893
Molecular Function	GO:0005515	protein binding	DLD	IPI	UniProtKB:O00330	Human	PMID:16263718
Molecular Function	GO:0005515	protein binding	DLD	IPI	UniProtKB:O00330	Human	PMID:16442803
Molecular Function	GO:0005515	protein binding	DLD	IPI	UniProtKB:O00330	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	DLD	IPI	UniProtKB:P30041	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	DLD	IPI	UniProtKB:P62258	Human	PMID:29128334
Molecular Function	GO:0005515	protein binding	DLD	IPI	UniProtKB:O00330	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DLD	IPI	UniProtKB:O14713	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DLD	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Dld	IPI	UniProtKB:O54910	Mouse	MGI:MGI:6189615|PMID:29128334
Molecular Function	GO:0034604	pyruvate dehydrogenase (NAD+) activity	DLD	IDA		Human	PMID:9242632
Cellular Component	GO:1902493	acetyltransferase complex	Dld	IMP	MGI:MGI:2182403	Mouse	PMID:9405644
Cellular Component	GO:0043159	acrosomal matrix	Dld	IDA		Mouse	PMID:15888450
Cellular Component	GO:0005929	cilium	Dld	IDA		Mouse	PMID:15888450
Cellular Component	GO:0045240	dihydrolipoyl dehydrogenase complex	Dld	IMP	MGI:MGI:2182403	Mouse	PMID:9405644
Cellular Component	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	DLD	IPI		Human	PMID:3593587
Cellular Component	GO:0005759	mitochondrial matrix	Dld	IDA		Mouse	PMID:9405644
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	DLD	IPI		Human	PMID:19240034
Cellular Component	GO:0005967	mitochondrial pyruvate dehydrogenase complex	Dld	IMP	MGI:MGI:2182403	Mouse	PMID:9405644
Cellular Component	GO:0005739	mitochondrion	DLD	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	DLD	IDA		Human	PMID:29211711
Cellular Component	GO:0005739	mitochondrion	Dld	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Dld	IDA		Mouse	PMID:15888450
Cellular Component	GO:0005739	mitochondrion	Dld	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Dld	IDA		Rat	PMID:3571202|RGD:2306876
Cellular Component	GO:0005739	mitochondrion	Dld	IDA		Rat	PMID:3753688|RGD:2289893
Cellular Component	GO:0005739	mitochondrion	Dld	IDA		Rat	PMID:7487891|RGD:1599112
Cellular Component	GO:0005739	mitochondrion	Dld	IDA		Rat	PMID:8981046|RGD:2289895
Cellular Component	GO:0043209	myelin sheath	Dld	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005634	nucleus	DLD	IDA		Human	PMID:29211711
Cellular Component	GO:0045252	oxoglutarate dehydrogenase complex	DLD	IDA		Human	PMID:29211711
Cellular Component	GO:0045252	oxoglutarate dehydrogenase complex	Dld	IMP	MGI:MGI:2182403	Mouse	PMID:15356189
Cellular Component	GO:0045252	oxoglutarate dehydrogenase complex	Dld	IDA		Rat	PMID:3571202|RGD:2306876
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	DLD	IDA		Human	PMID:9242632
Cellular Component	GO:0045254	pyruvate dehydrogenase complex	Dld	IDA		Rat	PMID:7487891|RGD:1599112
Biological Process	GO:0006103	2-oxoglutarate metabolic process	Dld	IDA		Rat	PMID:3571202|RGD:2306876
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	DLD	IDA		Human	PMID:24534072
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Dld	IMP		Mouse	PMID:27621431
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Dld	IMP	MGI:MGI:2386703	Mouse	PMID:17314311
Biological Process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	Dld	IDA		Rat	PMID:7487891|RGD:1599112
Biological Process	GO:0007568	aging	Dld	IEP		Rat	PMID:18316113|RGD:2306416
Biological Process	GO:0009083	branched-chain amino acid catabolic process	DLD	IDA		Human	PMID:3593587
Biological Process	GO:0051068	dihydrolipoamide metabolic process	Dld	IDA		Rat	PMID:8981046|RGD:2289895
Biological Process	GO:0007369	gastrulation	Dld	IMP	MGI:MGI:2182403	Mouse	PMID:9405644
Biological Process	GO:0060047	heart contraction	dldh	IMP	ZFIN:ZDB-MRPHLNO-150226-4	Zfish	PMID:25697682
Biological Process	GO:0106077	histone succinylation	DLD	IDA		Human	PMID:29211711
Biological Process	GO:0009106	lipoate metabolic process	Dld	IDA		Rat	PMID:8981046|RGD:2289895
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	Dld	IMP	MGI:MGI:2182403	Mouse	PMID:15009635
Biological Process	GO:0006508	proteolysis	Dld	IDA		Mouse	PMID:17404228
Biological Process	GO:0042391	regulation of membrane potential	Dld	IMP	MGI:MGI:2182403	Mouse	PMID:15009635
Biological Process	GO:0048240	sperm capacitation	Dld	IDA		Mouse	PMID:15888450

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern