Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DLL3
  • Mouse genes Dll3
  • Rat genes Dll3
  • Zfish genes dlb,dlc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dll3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	dlc	IDA		Zfish	PMID:18296487
Molecular Function	GO:0005112	Notch binding	Dll3	IPI	RGD:737367	Rat	PMID:16144902|RGD:1599776
Molecular Function	GO:0030165	PDZ domain binding	dlc	IPI	UniProtKB:Q5WPB2	Zfish	PMID:15509766
Molecular Function	GO:0030165	PDZ domain binding	dlc	IDA		Zfish	PMID:15509766
Molecular Function	GO:0005515	protein binding	Dll3	IPI	PR:O35516	Mouse	PMID:34635817
Molecular Function	GO:0005515	protein binding	Dll3	IPI	PR:A2AFI6	Mouse	PMID:34635817
Molecular Function	GO:0005515	protein binding	Dll3	IPI	PR:Q80SY4	Mouse	PMID:16000382
Cellular Component	GO:0005737	cytoplasm	dlc	IDA		Zfish	PMID:19056830
Cellular Component	GO:0048471	perinuclear region of cytoplasm	dlc	IGI	ZFIN:ZDB-GENE-050628-1	Zfish	PMID:17196985
Cellular Component	GO:0048471	perinuclear region of cytoplasm	dlc	IGI	ZFIN:ZDB-GENE-030404-2	Zfish	PMID:17196985
Cellular Component	GO:0005886	plasma membrane	Dll3	IDA		Mouse	PMID:34635817
Cellular Component	GO:0005886	plasma membrane	dlc	IDA		Zfish	PMID:17196985
Biological Process	GO:0060842	arterial endothelial cell differentiation	dlc	IMP	ZFIN:ZDB-MRPHLNO-050531-2	Zfish	PMID:24598161
Biological Process	GO:0048514	blood vessel morphogenesis	dlc	IMP	ZFIN:ZDB-GENO-130820-155	Zfish	PMID:16607654
Biological Process	GO:0048514	blood vessel morphogenesis	dlc	IMP	ZFIN:ZDB-MRPHLNO-060712-1	Zfish	PMID:16607654
Biological Process	GO:0048514	blood vessel morphogenesis	dlc	IMP	ZFIN:ZDB-GENO-130820-153	Zfish	PMID:16607654
Biological Process	GO:0048514	blood vessel morphogenesis	dlc	IMP	ZFIN:ZDB-MRPHLNO-060712-2	Zfish	PMID:16607654
Biological Process	GO:0007417	central nervous system development	Dll3	IEP		Rat	PMID:14743446|RGD:1304491
Biological Process	GO:0007386	compartment pattern specification	Dll3	IMP	MGI:MGI:1857008	Mouse	PMID:12001066
Biological Process	GO:0021536	diencephalon development	dlb	IGI	ZFIN:ZDB-GENO-120731-2	Zfish	PMID:21148001
Biological Process	GO:0021536	diencephalon development	dlb	IMP	ZFIN:ZDB-GENO-080605-3	Zfish	PMID:21148001
Biological Process	GO:0021536	diencephalon development	dlb	IGI	ZFIN:ZDB-GENO-120731-3	Zfish	PMID:21148001
Biological Process	GO:0021536	diencephalon development	dlb	IGI	ZFIN:ZDB-GENO-120731-4	Zfish	PMID:21148001
Biological Process	GO:0035907	dorsal aorta development	dlc	IGI	ZFIN:ZDB-GENO-101105-1,ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:24598161
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	dlc	IMP		Zfish	ZFIN:ZDB-PUB-170214-264
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	dlc	IGI	ZFIN:ZDB-GENO-100412-15,ZFIN:ZDB-MRPHLNO-070614-5	Zfish	PMID:25230933
Biological Process	GO:0060218	hematopoietic stem cell differentiation	dlc	IMP	ZFIN:ZDB-GENO-101105-1	Zfish	PMID:21654806
Biological Process	GO:0060218	hematopoietic stem cell differentiation	dlc	IGI	ZFIN:ZDB-GENO-101105-1,ZFIN:ZDB-MRPHLNO-081030-1	Zfish	PMID:21654806
Biological Process	GO:0030901	midbrain development	dlb	IGI	ZFIN:ZDB-GENO-120731-2	Zfish	PMID:21148001
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	Dll3	IDA		Rat	PMID:16144902|RGD:1599776
Biological Process	GO:0050768	negative regulation of neurogenesis	Dll3	IDA		Mouse	PMID:9272948
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Dll3	IDA		Rat	PMID:16144902|RGD:1599776
Biological Process	GO:0048666	neuron development	dlc	IMP	ZFIN:ZDB-GENO-980202-1156	Zfish	PMID:16125692
Biological Process	GO:0048666	neuron development	dlc	IMP	ZFIN:ZDB-GENO-980202-1157	Zfish	PMID:16125692
Biological Process	GO:0048666	neuron development	dlc	IMP	ZFIN:ZDB-GENO-070123-4	Zfish	PMID:16125692
Biological Process	GO:0048666	neuron development	dlc	IMP	ZFIN:ZDB-GENO-050621-3	Zfish	PMID:16125692
Biological Process	GO:0048666	neuron development	dlc	IMP	ZFIN:ZDB-GENO-051114-1	Zfish	PMID:16125692
Biological Process	GO:0007219	Notch signaling pathway	dlc	IMP	ZFIN:ZDB-GENO-101105-1	Zfish	PMID:21654806
Biological Process	GO:0048339	paraxial mesoderm development	Dll3	IMP	MGI:MGI:1857008	Mouse	PMID:15170697
Biological Process	GO:0050769	positive regulation of neurogenesis	Dll3	IDA		Rat	PMID:16144902|RGD:1599776
Biological Process	GO:0061056	sclerotome development	dlc	IGI	ZFIN:ZDB-GENO-100412-15,ZFIN:ZDB-MRPHLNO-070614-5	Zfish	PMID:25230933
Biological Process	GO:0001501	skeletal system development	DLL3	IMP		Human	PMID:10742114
Biological Process	GO:0001501	skeletal system development	Dll3	IMP		Mouse	MGI:MGI:2178102|PMID:11923214
Biological Process	GO:0001757	somite specification	dlc	IGI	ZFIN:ZDB-GENO-120725-3	Zfish	PMID:22723933
Biological Process	GO:0001756	somitogenesis	Dll3	IDA		Mouse	PMID:9272948
Biological Process	GO:0001756	somitogenesis	Dll3	IMP	MGI:MGI:1857008	Mouse	PMID:15170697
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-050621-3	Zfish	PMID:16125692
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-980202-1157	Zfish	PMID:16125692
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-051114-1	Zfish	PMID:16125692
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-980202-1156	Zfish	PMID:9706695
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-070123-4	Zfish	PMID:16125692
Biological Process	GO:0001756	somitogenesis	dlc	IGI	ZFIN:ZDB-GENO-070123-4,ZFIN:ZDB-MRPHLNO-050531-3,ZFIN:ZDB-MRPHLNO-050531-4	Zfish	PMID:15766754
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-980202-1156	Zfish	PMID:9007237
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-130820-155	Zfish	PMID:16607654
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-100823-1	Zfish	PMID:29624170
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-070123-4	Zfish	PMID:16545363
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-070123-4	Zfish	PMID:9007237
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-980202-1156	Zfish	PMID:16125692
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-980202-1157	Zfish	PMID:9007237
Biological Process	GO:0001756	somitogenesis	dlc	IEP		Zfish	PMID:16760970
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-110812-5	Zfish	PMID:24715465
Biological Process	GO:0001756	somitogenesis	dlc	IGI	ZFIN:ZDB-MRPHLNO-050526-1,ZFIN:ZDB-MRPHLNO-050526-2,ZFIN:ZDB-MRPHLNO-050531-3,ZFIN:ZDB-MRPHLNO-050531-4	Zfish	PMID:15766754
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-MRPHLNO-050531-3,ZFIN:ZDB-MRPHLNO-050531-4	Zfish	PMID:15766754
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-051214-4	Zfish	PMID:16225858
Biological Process	GO:0001756	somitogenesis	dlc	IMP	ZFIN:ZDB-GENO-130820-153	Zfish	PMID:16607654
Biological Process	GO:0009888	tissue development	Dll3	IDA		Mouse	PMID:9272948
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	dlc	IGI	ZFIN:ZDB-GENE-980526-29	Zfish	PMID:24768892
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	dlc	IGI	ZFIN:ZDB-GENE-980526-29,ZFIN:ZDB-GENE-990415-47	Zfish	PMID:24768892

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern