Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DLL4
  • Mouse genes Dll4
  • Rat genes Dll4
  • Zfish genes dll4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dll4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005112	Notch binding	DLL4	IPI	UniProtKB:P46531	Human	PMID:23839946
Molecular Function	GO:0005112	Notch binding	Dll4	IPI	PR:P31695	Mouse	PMID:20947685
Molecular Function	GO:0005112	Notch binding	Dll4	IDA		Mouse	PMID:10837024
Molecular Function	GO:0005515	protein binding	DLL4	IPI	UniProtKB:P57105	Human	PMID:24025447
Molecular Function	GO:0005515	protein binding	Dll4	IPI	UniProtKB:A8MQ27|UniProtKB:Q923S6	Mouse	MGI:MGI:5700298|PMID:19723503
Molecular Function	GO:0005515	protein binding	Dll4	IPI	PR:Q80SY4	Mouse	PMID:16000382
Molecular Function	GO:0048018	receptor ligand activity	DLL4	IDA		Human	PMID:23839946
Cellular Component	GO:0005737	cytoplasm	Dll4	IDA		Rat	PMID:21209419|RGD:155663486
Cellular Component	GO:0005886	plasma membrane	Dll4	IDA		Rat	PMID:21209419|RGD:155663486
Biological Process	GO:0001525	angiogenesis	Dll4	IMP	MGI:MGI:3056460	Mouse	PMID:15466160
Biological Process	GO:0001525	angiogenesis	Dll4	IMP	MGI:MGI:5302387	Mouse	PMID:23918385
Biological Process	GO:0001525	angiogenesis	dll4	IGI	ZFIN:ZDB-GENE-050407-1	Zfish	PMID:28087639
Biological Process	GO:0001525	angiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-130607-5	Zfish	PMID:22207734
Biological Process	GO:0001525	angiogenesis	dll4	IGI	ZFIN:ZDB-GENE-040303-4,ZFIN:ZDB-GENE-070810-6	Zfish	PMID:28087639
Biological Process	GO:0001525	angiogenesis	dll4	IGI	ZFIN:ZDB-GENE-040303-4	Zfish	PMID:28087639
Biological Process	GO:0001525	angiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-070509-1	Zfish	PMID:23086751
Biological Process	GO:0001525	angiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:28087639
Biological Process	GO:0001525	angiogenesis	dll4	IMP	ZFIN:ZDB-GENO-070626-1	Zfish	PMID:17251261
Biological Process	GO:0003180	aortic valve morphogenesis	DLL4	IDA		Human	PMID:26491108
Biological Process	GO:0060840	artery development	dll4	IMP	ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:24598161
Biological Process	GO:0060840	artery development	dll4	IMP	ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:19906867
Biological Process	GO:0001568	blood vessel development	dll4	IGI	ZFIN:ZDB-GENO-210922-2,ZFIN:ZDB-MRPHLNO-210311-1,ZFIN:ZDB-MRPHLNO-070509-1,ZFIN:ZDB-MRPHLNO-051121-1	Zfish	PMID:30656567
Biological Process	GO:0043534	blood vessel endothelial cell migration	dll4	IMP	ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:23462469
Biological Process	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	dll4	IGI	ZFIN:ZDB-MRPHLNO-070509-1,ZFIN:ZDB-MRPHLNO-140324-1	Zfish	PMID:23817492
Biological Process	GO:0072554	blood vessel lumenization	Dll4	IMP		Mouse	MGI:MGI:3056004|PMID:15466160
Biological Process	GO:0001974	blood vessel remodeling	Dll4	IMP		Mouse	MGI:MGI:3056004|PMID:15466160
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Dll4	IMP		Mouse	MGI:MGI:3056036|PMID:15466159
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	dll4	IGI	ZFIN:ZDB-GENO-130719-1,ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:23462469
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:23462469
Biological Process	GO:0060854	branching involved in lymph vessel morphogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-070626-1,ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:20466977
Biological Process	GO:0003209	cardiac atrium morphogenesis	Dll4	IMP		Mouse	MGI:MGI:3056036|PMID:15466159
Biological Process	GO:0003208	cardiac ventricle morphogenesis	Dll4	IMP		Mouse	MGI:MGI:3056036|PMID:15466159
Biological Process	GO:0071397	cellular response to cholesterol	Dll4	IEP		Rat	PMID:28472949|RGD:155646131
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	DLL4	IDA		Human	PMID:20616313
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Dll4	IEP		Rat	PMID:30653356|RGD:155663383
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	DLL4	IMP		Human	PMID:20616313
Biological Process	GO:0002062	chondrocyte differentiation	Dll4	IEP		Rat	PMID:26872979|RGD:11521858
Biological Process	GO:0035907	dorsal aorta development	dll4	IGI	ZFIN:ZDB-GENO-101105-1,ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:24598161
Biological Process	GO:0035912	dorsal aorta morphogenesis	Dll4	IMP		Mouse	MGI:MGI:3056036|PMID:15466159
Biological Process	GO:0035912	dorsal aorta morphogenesis	Dll4	IMP		Mouse	MGI:MGI:3056004|PMID:15466160
Biological Process	GO:0001554	luteolysis	Dll4	IEP		Rat	PMID:21209419|RGD:155663486
Biological Process	GO:0001946	lymphangiogenesis	dll4	IGI	ZFIN:ZDB-MRPHLNO-100205-5,ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:24069224
Biological Process	GO:0001946	lymphangiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-070626-1,ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:20466977
Biological Process	GO:0001946	lymphangiogenesis	dll4	IGI	ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:24069224
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	Dll4	IDA		Mouse	PMID:18559979
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	dll4	IMP	ZFIN:ZDB-MRPHLNO-070626-1	Zfish	PMID:17251261
Biological Process	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	DLL4	IDA		Human	PMID:23388056
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	DLL4	IMP		Human	PMID:20616313
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	DLL4	IDA		Human	PMID:23388056
Biological Process	GO:0008285	negative regulation of cell population proliferation	DLL4	IMP		Human	PMID:20616313
Biological Process	GO:0010596	negative regulation of endothelial cell migration	DLL4	IMP		Human	PMID:20616313
Biological Process	GO:0010629	negative regulation of gene expression	DLL4	IDA		Human	PMID:23388056
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Dll4	IDA		Mouse	MGI:MGI:5689216|PMID:26114479
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-070626-1	Zfish	PMID:27780917
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dll4	IMP		Mouse	MGI:MGI:3056036|PMID:15466159
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation	dll4	IMP	ZFIN:ZDB-MRPHLNO-070626-1	Zfish	PMID:27780917
Biological Process	GO:0061314	Notch signaling involved in heart development	Dll4	IMP		Mouse	MGI:MGI:3056036|PMID:15466159
Biological Process	GO:0007219	Notch signaling pathway	DLL4	IDA		Human	PMID:23839946
Biological Process	GO:0007219	Notch signaling pathway	Dll4	IDA		Mouse	PMID:24667410
Biological Process	GO:0033340	pelvic fin development	dll4	IMP	ZFIN:ZDB-GENO-180503-21	Zfish	PMID:28835471
Biological Process	GO:0033340	pelvic fin development	dll4	IMP	ZFIN:ZDB-GENO-180503-31	Zfish	PMID:28835471
Biological Process	GO:0033340	pelvic fin development	dll4	IMP	ZFIN:ZDB-GENO-180503-29	Zfish	PMID:28835471
Biological Process	GO:0033340	pelvic fin development	dll4	IMP	ZFIN:ZDB-GENO-180503-30	Zfish	PMID:28835471
Biological Process	GO:0003344	pericardium morphogenesis	Dll4	IMP		Mouse	MGI:MGI:3056036|PMID:15466159
Biological Process	GO:0010628	positive regulation of gene expression	DLL4	IDA		Human	PMID:23839946
Biological Process	GO:0010628	positive regulation of gene expression	DLL4	IDA		Human	PMID:23388056
Biological Process	GO:0010628	positive regulation of gene expression	DLL4	IDA		Human	PMID:26491108
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Dll4	IMP		Mouse	MGI:MGI:5314555|PMID:22323600
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	Dll4	IDA		Mouse	MGI:MGI:5689216|PMID:26114479
Biological Process	GO:0045765	regulation of angiogenesis	dll4	IGI	ZFIN:ZDB-GENE-980526-326,ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:19906867
Biological Process	GO:0045765	regulation of angiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:19906867
Biological Process	GO:0045765	regulation of angiogenesis	dll4	IGI	ZFIN:ZDB-MRPHLNO-051212-2,ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:19906867
Biological Process	GO:0061074	regulation of neural retina development	Dll4	IMP		Mouse	MGI:MGI:5314555|PMID:22323600
Biological Process	GO:0050767	regulation of neurogenesis	Dll4	IMP	MGI:MGI:3056400	Mouse	PMID:19389377
Biological Process	GO:1903670	regulation of sprouting angiogenesis	dll4	IGI	ZFIN:ZDB-GENE-120508-5	Zfish	PMID:28254818
Biological Process	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	dll4	IMP	ZFIN:ZDB-GENO-100208-5,ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:19906867
Biological Process	GO:0002040	sprouting angiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:32955436
Biological Process	GO:0002040	sprouting angiogenesis	dll4	IGI	ZFIN:ZDB-MRPHLNO-070509-1,ZFIN:ZDB-MRPHLNO-140324-1	Zfish	PMID:23817492
Biological Process	GO:0002040	sprouting angiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:17259972
Biological Process	GO:0002040	sprouting angiogenesis	dll4	IGI	ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:24069224
Biological Process	GO:0002040	sprouting angiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-070509-1	Zfish	PMID:17259972
Biological Process	GO:0002040	sprouting angiogenesis	dll4	IMP	ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:23462469
Biological Process	GO:0002040	sprouting angiogenesis	dll4	IGI	ZFIN:ZDB-GENO-130718-6,ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:23462469
Biological Process	GO:0002040	sprouting angiogenesis	dll4	IGI	ZFIN:ZDB-MRPHLNO-100205-5,ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:24069224
Biological Process	GO:0030217	T cell differentiation	Dll4	IDA		Mouse	MGI:MGI:3044313|PMID:15146182
Biological Process	GO:0060841	venous blood vessel development	dll4	IMP	ZFIN:ZDB-MRPHLNO-130607-5	Zfish	PMID:22207734
Biological Process	GO:0060855	venous endothelial cell migration involved in lymph vessel development	dll4	IMP	ZFIN:ZDB-MRPHLNO-070626-1,ZFIN:ZDB-MRPHLNO-100205-5	Zfish	PMID:20466977
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	dll4	IMP	ZFIN:ZDB-MRPHLNO-070509-2	Zfish	PMID:24768892
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	dll4	IGI	ZFIN:ZDB-GENE-980526-29	Zfish	PMID:24768892
Biological Process	GO:0060579	ventral spinal cord interneuron fate commitment	DLL4	IMP	UniProtKB:Q8K3Q3	Human	PMID:17728344
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	Dll4	IMP		Mouse	MGI:MGI:3056036|PMID:15466159

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern