Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DLX2
  • Mouse genes Dlx2
  • Rat genes Dlx2
  • Zfish genes dlx2a,dlx2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dlx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Dlx2	IDA		Mouse	PMID:14769946
Molecular Function	GO:0003677	DNA binding	Dlx2	IDA		Mouse	PMID:14769946
Molecular Function	GO:0003677	DNA binding	Dlx2	IDA		Mouse	PMID:9415433
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Dlx2	IDA		Mouse	MGI:MGI:3032902|PMID:14769946
Molecular Function	GO:0005515	protein binding	DLX2	IPI	UniProtKB:P28799	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Dlx2	IPI	UniProtKB:Q63934	Mouse	MGI:MGI:5316576|PMID:21875655
Molecular Function	GO:0005515	protein binding	Dlx2	IPI	PR:Q61026	Mouse	PMID:11675124
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Dlx2	IDA		Mouse	MGI:MGI:3032902|PMID:14769946
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	DLX2	IDA		Human	PMID:28473536
Molecular Function	GO:0003727	single-stranded RNA binding	Dlx2	IPI	EMBL:AK038694	Mouse	PMID:16705037
Cellular Component	GO:0005634	nucleus	Dlx2	IDA		Mouse	PMID:12397111
Cellular Component	GO:0005634	nucleus	Dlx2	IDA		Mouse	PMID:10516593
Cellular Component	GO:0005634	nucleus	Dlx2	IDA		Mouse	PMID:12724837
Biological Process	GO:0048755	branching morphogenesis of a nerve	Dlx2	IMP	MGI:MGI:1857828	Mouse	PMID:7590232
Biological Process	GO:0051216	cartilage development	Dlx2	IMP	MGI:MGI:1857828	Mouse	PMID:7590232
Biological Process	GO:0051216	cartilage development	dlx2a	IMP	ZFIN:ZDB-MRPHLNO-080429-2	Zfish	PMID:18158147
Biological Process	GO:0051216	cartilage development	dlx2a	IGI	ZFIN:ZDB-MRPHLNO-080429-1,ZFIN:ZDB-MRPHLNO-080429-2	Zfish	PMID:18158147
Biological Process	GO:0021892	cerebral cortex GABAergic interneuron differentiation	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:15028753
Biological Process	GO:0021893	cerebral cortex GABAergic interneuron fate commitment	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:17678855
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	Dlx2	IMP	MGI:MGI:1857828	Mouse	PMID:7590232
Biological Process	GO:0048706	embryonic skeletal system development	Dlx2	IMP	MGI:MGI:1857828	Mouse	PMID:9187081
Biological Process	GO:0048706	embryonic skeletal system development	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:9187081
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	dlx2a	IMP	ZFIN:ZDB-MRPHLNO-180314-1	Zfish	PMID:29128566
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	dlx2a	IGI	ZFIN:ZDB-MRPHLNO-080429-1,ZFIN:ZDB-MRPHLNO-080429-2	Zfish	PMID:20573696
Biological Process	GO:0021879	forebrain neuron differentiation	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:11163262
Biological Process	GO:0097154	GABAergic neuron differentiation	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:11163262
Biological Process	GO:0021766	hippocampus development	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:11163262
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:23042297
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:17678855
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:23042297
Biological Process	GO:0046533	negative regulation of photoreceptor cell differentiation	Dlx2	IMP		Mouse	MGI:MGI:5316576|PMID:21875655
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:17678855
Biological Process	GO:0014032	neural crest cell development	dlx2a	IMP	ZFIN:ZDB-MRPHLNO-080429-2	Zfish	PMID:18158147
Biological Process	GO:0014016	neuroblast differentiation	Dlx2	IMP	MGI:MGI:1857828	Mouse	PMID:12397111
Biological Process	GO:0007219	Notch signaling pathway	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:23042297
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:9187081
Biological Process	GO:0021772	olfactory bulb development	Dlx2	IMP	MGI:MGI:1857828	Mouse	PMID:7590232
Biological Process	GO:0048709	oligodendrocyte differentiation	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:17678855
Biological Process	GO:0048709	oligodendrocyte differentiation	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:23042297
Biological Process	GO:0007422	peripheral nervous system development	dlx2a	IMP	ZFIN:ZDB-MRPHLNO-080429-2	Zfish	PMID:18158147
Biological Process	GO:0060037	pharyngeal system development	dlx2a	IMP	ZFIN:ZDB-MRPHLNO-080429-2	Zfish	PMID:18158147
Biological Process	GO:1902871	positive regulation of amacrine cell differentiation	Dlx2	IMP		Mouse	MGI:MGI:5316576|PMID:21875655
Biological Process	GO:0045597	positive regulation of cell differentiation	Dlx2	IMP		Mouse	MGI:MGI:5316576|PMID:21875655
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Dlx2	IDA		Mouse	MGI:MGI:3032902|PMID:14769946
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Dlx2	IGI	MGI:MGI:2443217	Mouse	PMID:16705037
Biological Process	GO:0009954	proximal/distal pattern formation	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:9187081
Biological Process	GO:0009954	proximal/distal pattern formation	Dlx2	IMP	MGI:MGI:1857828	Mouse	PMID:9187081
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:17678855
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:22920256
Biological Process	GO:0032868	response to insulin	Dlx2	IEP		Rat	PMID:20818503|RGD:151667419
Biological Process	GO:0014070	response to organic cyclic compound	Dlx2	IEP		Rat	PMID:20818503|RGD:151667419
Biological Process	GO:0042254	ribosome biogenesis	dlx2a	IMP	ZFIN:ZDB-GENO-150623-3	Zfish	PMID:25913037
Biological Process	GO:0021544	subpallium development	Dlx2	IGI	MGI:MGI:95843	Mouse	PMID:23042297
Biological Process	GO:0021544	subpallium development	Dlx2	IGI	MGI:MGI:94901	Mouse	PMID:23042297

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern