Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DLX5
  • Mouse genes Dlx5
  • Rat genes Dlx5
  • Zfish genes dlx5a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dlx5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Dlx5	IDA		Mouse	PMID:9415433
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Dlx5	IDA		Mouse	MGI:MGI:5487530|PMID:20843790
Molecular Function	GO:0071837	HMG box domain binding	Dlx5	IPI	UniProtKB:O55170|UniProtKB:Q05066	Mouse	MGI:MGI:5284787|PMID:16582099
Molecular Function	GO:0005515	protein binding	Dlx5	IPI	PR:Q9QYH6	Mouse	PMID:11084035
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Dlx5	IDA		Mouse	MGI:MGI:5487530|PMID:20843790
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	DLX5	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	DLX5	IDA		Human	PMID:19497851
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Dlx5	IDA		Mouse	MGI:MGI:3522068|PMID:15383550
Cellular Component	GO:0000785	chromatin	Dlx5	IDA		Mouse	MGI:MGI:5487530|PMID:20843790
Cellular Component	GO:0005737	cytoplasm	Dlx5	IDA		Mouse	PMID:10516593
Cellular Component	GO:0005634	nucleus	Dlx5	IDA		Mouse	PMID:10516593
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Dlx5	IGI	MGI:MGI:101927	Mouse	PMID:17878916
Biological Process	GO:0007411	axon guidance	Dlx5	IMP	MGI:MGI:2180475	Mouse	PMID:17804636
Biological Process	GO:0007409	axonogenesis	Dlx5	IMP	MGI:MGI:1857789	Mouse	PMID:12533617
Biological Process	GO:0030509	BMP signaling pathway	Dlx5	IMP		Mouse	MGI:MGI:5487530|PMID:20843790
Biological Process	GO:0060349	bone morphogenesis	Dlx5	IMP	MGI:MGI:2180474	Mouse	PMID:16330189
Biological Process	GO:0051216	cartilage development	dlx5a	IGI	ZFIN:ZDB-MRPHLNO-041109-1,ZFIN:ZDB-MRPHLNO-060822-7	Zfish	PMID:16678149
Biological Process	GO:0008283	cell population proliferation	DLX5	IDA		Human	PMID:19497851
Biological Process	GO:0071773	cellular response to BMP stimulus	Dlx5	IMP		Mouse	MGI:MGI:5487530|PMID:20843790
Biological Process	GO:0034224	cellular response to zinc ion starvation	Dlx5	IEP		Rat	PMID:21893222|RGD:151667428
Biological Process	GO:0043583	ear development	Dlx5	IMP	MGI:MGI:2180474	Mouse	PMID:16330189
Biological Process	GO:0030326	embryonic limb morphogenesis	Dlx5	IGI	MGI:MGI:101927	Mouse	PMID:12112878
Biological Process	GO:0030326	embryonic limb morphogenesis	Dlx5	IGI	MGI:MGI:101927	Mouse	PMID:18326838
Biological Process	GO:0030326	embryonic limb morphogenesis	Dlx5	IGI	MGI:MGI:1330810	Mouse	PMID:18326838
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	dlx5a	IGI	ZFIN:ZDB-MRPHLNO-041109-1,ZFIN:ZDB-MRPHLNO-060822-7	Zfish	PMID:20573696
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	dlx5a	IGI	ZFIN:ZDB-GENO-100809-9,ZFIN:ZDB-MRPHLNO-041109-1,ZFIN:ZDB-MRPHLNO-050209-12,ZFIN:ZDB-MRPHLNO-060822-7	Zfish	PMID:20573696
Biological Process	GO:0001958	endochondral ossification	Dlx5	IMP		Mouse	MGI:MGI:4413604|PMID:19956613
Biological Process	GO:0030855	epithelial cell differentiation	Dlx5	IGI	MGI:MGI:101927	Mouse	PMID:17878916
Biological Process	GO:0060325	face morphogenesis	Dlx5	IMP	MGI:MGI:2180474	Mouse	PMID:16330189
Biological Process	GO:0033334	fin morphogenesis	dlx5a	IMP	ZFIN:ZDB-MRPHLNO-060822-7	Zfish	PMID:24278401
Biological Process	GO:0060322	head development	Dlx5	IGI	MGI:MGI:101927	Mouse	PMID:15306564
Biological Process	GO:0042472	inner ear morphogenesis	Dlx5	IGI	MGI:MGI:101927	Mouse	PMID:16900517
Biological Process	GO:0042472	inner ear morphogenesis	Dlx5	IMP	MGI:MGI:2180474	Mouse	PMID:12142028
Biological Process	GO:0097376	interneuron axon guidance	Dlx5	IMP	MGI:MGI:2180475	Mouse	PMID:25937343
Biological Process	GO:0035141	medial fin morphogenesis	dlx5a	IGI	ZFIN:ZDB-MRPHLNO-131023-2,ZFIN:ZDB-MRPHLNO-140923-10	Zfish	PMID:24858471
Biological Process	GO:0001841	neural tube formation	dlx5a	IMP	ZFIN:ZDB-MRPHLNO-131023-2,ZFIN:ZDB-MRPHLNO-140923-10	Zfish	PMID:30889190
Biological Process	GO:0021889	olfactory bulb interneuron differentiation	Dlx5	IMP	MGI:MGI:2180475	Mouse	PMID:25937343
Biological Process	GO:0021628	olfactory nerve formation	dlx5a	IMP	ZFIN:ZDB-MRPHLNO-060822-7,ZFIN:ZDB-MRPHLNO-140417-1	Zfish	PMID:24427155
Biological Process	GO:0060166	olfactory pit development	Dlx5	IMP	MGI:MGI:1857789	Mouse	PMID:12533617
Biological Process	GO:0071699	olfactory placode morphogenesis	dlx5a	IMP	ZFIN:ZDB-MRPHLNO-060822-7,ZFIN:ZDB-MRPHLNO-140417-1	Zfish	PMID:24427155
Biological Process	GO:0001649	osteoblast differentiation	Dlx5	IDA		Mouse	MGI:MGI:3522068|PMID:15383550
Biological Process	GO:0033339	pectoral fin development	dlx5a	IGI	ZFIN:ZDB-MRPHLNO-131023-2,ZFIN:ZDB-MRPHLNO-140923-10	Zfish	PMID:24858471
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Dlx5	IMP	MGI:MGI:2180475	Mouse	PMID:17804636
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	DLX5	IDA		Human	PMID:19497851
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Dlx5	IDA		Mouse	MGI:MGI:3522068|PMID:15383550
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Dlx5	IGI	MGI:MGI:101927	Mouse	PMID:16900517
Biological Process	GO:0010628	positive regulation of gene expression	Dlx5	IMP	MGI:MGI:2180475	Mouse	PMID:25937343
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Dlx5	IMP		Rat	PMID:12815054|RGD:1298882
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Dlx5	IGI	MGI:MGI:99458	Mouse	PMID:17420000
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	Dlx5	IMP		Mouse	MGI:MGI:5487530|PMID:20843790
Biological Process	GO:0006355	regulation of DNA-templated transcription	Dlx5	IMP	MGI:MGI:2180474	Mouse	PMID:12142028
Biological Process	GO:0009612	response to mechanical stimulus	dlx5a	IDA		Zfish	PMID:23632157
Biological Process	GO:0060021	roof of mouth development	Dlx5	IMP	MGI:MGI:2180474	Mouse	PMID:16330189
Biological Process	GO:0060021	roof of mouth development	Dlx5	IGI	MGI:MGI:99458	Mouse	PMID:17420000
Biological Process	GO:0060021	roof of mouth development	Dlx5	IGI	MGI:MGI:101927	Mouse	PMID:17420000

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern