Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DNA2
  • Mouse genes Dna2
  • Rat genes Dna2
  • Zfish genes dna2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dna2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043139	5'-3' DNA helicase activity	DNA2	IDA		Human	PMID:20019387
Molecular Function	GO:0017108	5'-flap endonuclease activity	DNA2	IDA		Human	PMID:16595799
Molecular Function	GO:0017108	5'-flap endonuclease activity	DNA2	IDA		Human	PMID:16595800
Molecular Function	GO:0017108	5'-flap endonuclease activity	DNA2	IDA		Human	PMID:18995831
Molecular Function	GO:0017108	5'-flap endonuclease activity	DNA2	IDA		Human	PMID:20019387
Molecular Function	GO:0017108	5'-flap endonuclease activity	DNA2	IDA		Human	PMID:22570407
Molecular Function	GO:0017108	5'-flap endonuclease activity	Dna2	IDA		Mouse	MGI:MGI:5499273|PMID:23604072
Molecular Function	GO:0003677	DNA binding	DNA2	IDA		Human	PMID:20019387
Molecular Function	GO:0003677	DNA binding	DNA2	IDA		Human	PMID:22570407
Molecular Function	GO:0003678	DNA helicase activity	DNA2	IDA		Human	PMID:16595800
Molecular Function	GO:0004518	nuclease activity	DNA2	IDA		Human	PMID:21325134
Molecular Function	GO:0005515	protein binding	DNA2	IPI	UniProtKB:Q09472	Human	PMID:20019387
Molecular Function	GO:0005515	protein binding	DNA2	IPI	UniProtKB:P54132	Human	PMID:21325134
Molecular Function	GO:0005515	protein binding	Dna2	IPI	UniProtKB:O35144|UniProtKB:P70371	Mouse	MGI:MGI:5499273|PMID:23604072
Molecular Function	GO:0017116	single-stranded DNA helicase activity	DNA2	IDA		Human	PMID:16595799
Molecular Function	GO:0017116	single-stranded DNA helicase activity	DNA2	IDA		Human	PMID:16595800
Molecular Function	GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base	DNA2	IDA		Human	PMID:18995831
Cellular Component	GO:0000781	chromosome, telomeric region	Dna2	IDA		Mouse	MGI:MGI:5499273|PMID:23604072
Cellular Component	GO:0042645	mitochondrial nucleoid	DNA2	IDA		Human	PMID:19487465
Cellular Component	GO:0005739	mitochondrion	DNA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	DNA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DNA2	IDA		Human	PMID:19487465
Biological Process	GO:0006284	base-excision repair	DNA2	IDA		Human	PMID:18995831
Biological Process	GO:0000729	DNA double-strand break processing	DNA2	IDA		Human	PMID:21325134
Biological Process	GO:0006260	DNA replication	DNA2	IMP		Human	PMID:22570476
Biological Process	GO:0000076	DNA replication checkpoint signaling	DNA2	IMP		Human	PMID:22570476
Biological Process	GO:0033567	DNA replication, Okazaki fragment processing	DNA2	IDA		Human	PMID:22570407
Biological Process	GO:0043137	DNA replication, removal of RNA primer	DNA2	IDA		Human	PMID:18995831
Biological Process	GO:0043504	mitochondrial DNA repair	DNA2	IDA		Human	PMID:19487465
Biological Process	GO:0006264	mitochondrial DNA replication	DNA2	IDA		Human	PMID:18995831
Biological Process	GO:0006264	mitochondrial DNA replication	DNA2	IDA		Human	PMID:19487465
Biological Process	GO:1902990	mitotic telomere maintenance via semi-conservative replication	Dna2	IMP		Mouse	MGI:MGI:5499273|PMID:23604072
Biological Process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	Dna2	IDA		Mouse	MGI:MGI:5499273|PMID:23604072
Biological Process	GO:0045740	positive regulation of DNA replication	DNA2	IDA		Human	PMID:18995831
Biological Process	GO:0000723	telomere maintenance	Dna2	IMP		Mouse	MGI:MGI:5499273|PMID:23604072

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern