Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DNM1L
  • Mouse genes Dnm1l
  • Rat genes Dnm1l
  • Zfish genes dnm1l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dnm1l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051433	BH2 domain binding	Dnm1l	IPI	UniProtKB:P53563	Rat	PMID:23792689|RGD:12793033
Molecular Function	GO:0030276	clathrin binding	Dnm1l	IPI	UniProtKB:P08081	Rat	PMID:23792689|RGD:12793033
Molecular Function	GO:0030742	GTP-dependent protein binding	DNM1L	IDA		Human	PMID:25767741
Molecular Function	GO:0003924	GTPase activity	DNM1L	IDA		Human	PMID:22265414
Molecular Function	GO:0003924	GTPase activity	DNM1L	IDA		Human	PMID:23530241
Molecular Function	GO:0042802	identical protein binding	DNM1L	IPI	UniProtKB:O00429	Human	PMID:18353969
Molecular Function	GO:0042802	identical protein binding	DNM1L	IPI	UniProtKB:O00429	Human	PMID:21701560
Molecular Function	GO:0042802	identical protein binding	DNM1L	IPI	UniProtKB:O00429	Human	PMID:30914652
Molecular Function	GO:0042802	identical protein binding	Dnm1l	IPI	RGD:620416	Rat	PMID:23658809|RGD:12738215
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9Y3D6	Human	PMID:12861026
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q08209	Human	PMID:18838687
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:P63279	Human	PMID:19638400
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9GZY8	Human	PMID:21149567
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9Y3D6	Human	PMID:21149567
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:P03372	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q96C03	Human	PMID:21508961
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9NQG6	Human	PMID:21701560
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q15311	Human	PMID:21822277
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q5S007	Human	PMID:22228096
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:P10636	Human	PMID:22367970
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q5S007	Human	PMID:22639965
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q96C03	Human	PMID:23283981
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9NQG6	Human	PMID:23283981
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q5S007	Human	PMID:23813973
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q5S007	Human	PMID:24282027
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q14160	Human	PMID:24550280
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9GZY8	Human	PMID:26358295
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q96QK1	Human	PMID:26618722
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9Y512	Human	PMID:27059175
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q96C03	Human	PMID:29464060
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9GZY8	Human	PMID:29464060
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9NQG6	Human	PMID:29464060
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9Y3D6	Human	PMID:29464060
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q5S007	Human	PMID:29541021
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9NVI7	Human	PMID:30914652
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:Q9NVI7-2	Human	PMID:30914652
Molecular Function	GO:0005515	protein binding	DNM1L	IPI	UniProtKB:P49841	Human	PMID:9731200
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:5538411|PMID:24282027
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:6355691|PMID:29541021
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	UniProtKB:Q6PCP5|UniProtKB:Q8BGV8|UniProtKB:Q925I1	Mouse	MGI:MGI:6286869|PMID:30914652
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	UniProtKB:Q5NCS9|UniProtKB:Q8BGV8	Mouse	MGI:MGI:5919039|PMID:24508339
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	UniProtKB:Q6PCP5	Mouse	MGI:MGI:6200588|PMID:30059978
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	UniProtKB:Q5S006	Mouse	MGI:MGI:5431272|PMID:22639965
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	PR:Q9WVS6	Mouse	PMID:28063983
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	UniProtKB:P53563-1	Rat	PMID:18250306|RGD:8553310
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	UniProtKB:P53563-1	Rat	PMID:23792689|RGD:12793033
Molecular Function	GO:0005515	protein binding	Dnm1l	IPI	UniProtKB:Q4KM98	Rat	PMID:23792689|RGD:12793033
Molecular Function	GO:0042803	protein homodimerization activity	DNM1L	IDA		Human	PMID:22265414
Molecular Function	GO:0042803	protein homodimerization activity	DNM1L	IDA		Human	PMID:23530241
Molecular Function	GO:0042803	protein homodimerization activity	Dnm1l	IDA		Mouse	MGI:MGI:4459561|PMID:20585624
Molecular Function	GO:0120283	protein serine/threonine kinase binding	Dnm1l	IPI	RGD:620760	Rat	PMID:20802490|RGD:152995511
Molecular Function	GO:0044877	protein-containing complex binding	Dnm1l	IPI	RGD:1310230|RGD:2200|RGD:70919	Rat	PMID:23792689|RGD:12793033
Molecular Function	GO:0031267	small GTPase binding	DNM1L	IDA		Human	PMID:25767741
Molecular Function	GO:0031625	ubiquitin protein ligase binding	DNM1L	IPI	UniProtKB:Q9NX47	Human	PMID:16874301
Molecular Function	GO:0031625	ubiquitin protein ligase binding	DNM1L	IPI	UniProtKB:Q969V5	Human	PMID:19407830
Cellular Component	GO:0005903	brush border	Dnm1l	IDA		Mouse	MGI:MGI:5621262|PMID:22114352
Cellular Component	GO:0005905	clathrin-coated pit	Dnm1l	IDA		Rat	PMID:23792689|RGD:12793033
Cellular Component	GO:0005737	cytoplasm	DNM1L	IDA		Human	PMID:12618434
Cellular Component	GO:0005737	cytoplasm	DNM1L	IDA		Human	PMID:21149567
Cellular Component	GO:0005737	cytoplasm	DNM1L	IDA		Human	PMID:23349293
Cellular Component	GO:0005737	cytoplasm	DNM1L	IMP		Human	PMID:28969390
Cellular Component	GO:0005829	cytosol	DNM1L	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	DNM1L	IMP		Human	PMID:11514614
Cellular Component	GO:0005829	cytosol	DNM1L	IDA		Human	PMID:22265414
Cellular Component	GO:0005829	cytosol	DNM1L	IDA		Human	PMID:23921378
Cellular Component	GO:0005829	cytosol	Dnm1l	IDA		Mouse	MGI:MGI:6200588|PMID:30059978
Cellular Component	GO:0005829	cytosol	Dnm1l	IMP		Mouse	MGI:MGI:5508698|PMID:23283981
Cellular Component	GO:0005829	cytosol	Dnm1l	IDA		Rat	PMID:12499366|RGD:1357948
Cellular Component	GO:0005829	cytosol	Dnm1l	IDA		Rat	PMID:9472031|RGD:11535088
Cellular Component	GO:0005783	endoplasmic reticulum	DNM1L	IDA		Human	PMID:9472031
Cellular Component	GO:0005783	endoplasmic reticulum	Dnm1l	IDA		Rat	PMID:9472031|RGD:11535088
Cellular Component	GO:0005794	Golgi apparatus	DNM1L	IDA		Human	PMID:20688057
Cellular Component	GO:0000139	Golgi membrane	Dnm1l	IDA		Rat	PMID:9472031|RGD:11535088
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	DNM1L	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Dnm1l	IDA		Rat	PMID:12499366|RGD:1357948
Cellular Component	GO:0016020	membrane	DNM1L	HDA		Human	PMID:19946888
Cellular Component	GO:0005874	microtubule	DNM1L	IDA		Human	PMID:9472031
Cellular Component	GO:0031966	mitochondrial membrane	Dnm1l	IDA		Rat	PMID:23792689|RGD:12793033
Cellular Component	GO:0005741	mitochondrial outer membrane	DNM1L	IDA		Human	PMID:21149567
Cellular Component	GO:0005741	mitochondrial outer membrane	DNM1L	IDA		Human	PMID:26122121
Cellular Component	GO:0005741	mitochondrial outer membrane	DNM1L	IDA		Human	PMID:27145208
Cellular Component	GO:0005741	mitochondrial outer membrane	Dnm1l	IDA		Mouse	MGI:MGI:5766079|PMID:26919426
Cellular Component	GO:0005741	mitochondrial outer membrane	Dnm1l	IDA		Mouse	MGI:MGI:6200588|PMID:30059978
Cellular Component	GO:0005741	mitochondrial outer membrane	Dnm1l	IDA		Mouse	PMID:21149567
Cellular Component	GO:0005739	mitochondrion	DNM1L	IDA		Human	PMID:11514614
Cellular Component	GO:0005739	mitochondrion	DNM1L	IDA		Human	PMID:21822277
Cellular Component	GO:0005739	mitochondrion	DNM1L	IDA		Human	PMID:22265414
Cellular Component	GO:0005739	mitochondrion	DNM1L	IDA		Human	PMID:23349293
Cellular Component	GO:0005739	mitochondrion	DNM1L	IDA		Human	PMID:23530241
Cellular Component	GO:0005739	mitochondrion	DNM1L	IDA		Human	PMID:23921378
Cellular Component	GO:0005739	mitochondrion	DNM1L	IDA		Human	PMID:24599962
Cellular Component	GO:0005739	mitochondrion	DNM1L	IDA		Human	PMID:26618722
Cellular Component	GO:0005739	mitochondrion	DNM1L	IMP		Human	PMID:28969390
Cellular Component	GO:0005739	mitochondrion	DNM1L	IDA		Human	PMID:29307555
Cellular Component	GO:0005739	mitochondrion	Dnm1l	IMP		Mouse	MGI:MGI:5508698|PMID:23283981
Cellular Component	GO:0005739	mitochondrion	Dnm1l	IDA		Mouse	PMID:24515348
Cellular Component	GO:0005739	mitochondrion	Dnm1l	IDA		Mouse	PMID:28063983
Cellular Component	GO:0005739	mitochondrion	Dnm1l	IDA		Mouse	PMID:26219591
Cellular Component	GO:0005739	mitochondrion	Dnm1l	IDA		Mouse	PMID:34048705
Cellular Component	GO:0005739	mitochondrion	Dnm1l	IDA		Rat	PMID:12499366|RGD:1357948
Cellular Component	GO:0099073	mitochondrion-derived vesicle	DNM1L	IDA		Human	PMID:26618722
Cellular Component	GO:0048471	perinuclear region of cytoplasm	DNM1L	IDA		Human	PMID:9472031
Cellular Component	GO:0048471	perinuclear region of cytoplasm	DNM1L	IDA		Human	PMID:9570752
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Dnm1l	IDA		Rat	PMID:9472031|RGD:11535088
Cellular Component	GO:0005777	peroxisome	DNM1L	IDA		Human	PMID:12618434
Cellular Component	GO:0005777	peroxisome	DNM1L	IMP		Human	PMID:23921378
Cellular Component	GO:0005777	peroxisome	Dnm1l	IDA		Rat	PMID:12499366|RGD:1357948
Cellular Component	GO:0098835	presynaptic endocytic zone membrane	Dnm1l	IDA		Rat	PMID:23792689|RGD:12793033
Cellular Component	GO:0032991	protein-containing complex	DNM1L	IDA		Human	PMID:17408615
Cellular Component	GO:0032991	protein-containing complex	DNM1L	IDA		Human	PMID:18353969
Cellular Component	GO:0099503	secretory vesicle	Dnm1l	IDA		Rat	PMID:9472031|RGD:11535088
Cellular Component	GO:0030672	synaptic vesicle membrane	Dnm1l	IDA		Rat	PMID:23792689|RGD:12793033
Biological Process	GO:0006816	calcium ion transport	Dnm1l	IMP	MGI:MGI:5312923	Mouse	PMID:28063983
Biological Process	GO:0071396	cellular response to lipid	Dnm1l	IEP		Rat	PMID:18006463|RGD:12738362
Biological Process	GO:0090650	cellular response to oxygen-glucose deprivation	Dnm1l	IEP		Rat	PMID:23658809|RGD:12738215
Biological Process	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	DNM1L	IDA		Human	PMID:11514614
Biological Process	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	DNM1L	IDA		Human	PMID:23530241
Biological Process	GO:0060047	heart contraction	Dnm1l	IMP		Mouse	MGI:MGI:4459561|PMID:20585624
Biological Process	GO:0048312	intracellular distribution of mitochondria	DNM1L	IMP		Human	PMID:11514614
Biological Process	GO:0048312	intracellular distribution of mitochondria	Dnm1l	IMP		Rat	PMID:19605646|RGD:7800727
Biological Process	GO:0061025	membrane fusion	DNM1L	IDA		Human	PMID:20850011
Biological Process	GO:0000266	mitochondrial fission	DNM1L	IMP		Human	PMID:23349293
Biological Process	GO:0000266	mitochondrial fission	DNM1L	IDA		Human	PMID:23530241
Biological Process	GO:0000266	mitochondrial fission	DNM1L	IMP		Human	PMID:23921378
Biological Process	GO:0000266	mitochondrial fission	DNM1L	IMP		Human	PMID:26992161
Biological Process	GO:0000266	mitochondrial fission	DNM1L	IMP		Human	PMID:27145208
Biological Process	GO:0000266	mitochondrial fission	Dnm1l	IMP		Mouse	MGI:MGI:5508698|PMID:23283981
Biological Process	GO:0000266	mitochondrial fission	Dnm1l	IMP		Mouse	PMID:22493254
Biological Process	GO:0000266	mitochondrial fission	Dnm1l	IMP		Mouse	PMID:20038678
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	DNM1L	IMP		Human	PMID:12499352
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	DNM1L	IMP		Human	PMID:18353969
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	DNM1L	IMP		Human	PMID:21149567
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	Dnm1l	IMP		Rat	PMID:17443673|RGD:12738363
Biological Process	GO:0090149	mitochondrial membrane fission	DNM1L	IDA		Human	PMID:11514614
Biological Process	GO:0090149	mitochondrial membrane fission	DNM1L	IMP		Human	PMID:21822277
Biological Process	GO:0090149	mitochondrial membrane fission	DNM1L	IMP		Human	PMID:27301544
Biological Process	GO:0090149	mitochondrial membrane fission	DNM1L	IMP		Human	PMID:27328748
Biological Process	GO:0070584	mitochondrion morphogenesis	DNM1L	IMP		Human	PMID:21149567
Biological Process	GO:0070584	mitochondrion morphogenesis	Dnm1l	IMP		Rat	PMID:19605646|RGD:7800727
Biological Process	GO:0007005	mitochondrion organization	DNM1L	IMP		Human	PMID:11514614
Biological Process	GO:0007005	mitochondrion organization	Dnm1l	IMP	MGI:MGI:5312923	Mouse	PMID:28063983
Biological Process	GO:0160040	mitocytosis	Dnm1l	IMP		Mouse	PMID:34048705
Biological Process	GO:0070266	necroptotic process	DNM1L	IMP		Human	PMID:22265414
Biological Process	GO:0070266	necroptotic process	Dnm1l	IMP		Mouse	MGI:MGI:5516181|PMID:22265414
Biological Process	GO:0010637	negative regulation of mitochondrial fusion	Dnm1l	IMP		Rat	PMID:23792689|RGD:12793033
Biological Process	GO:0016559	peroxisome fission	DNM1L	IDA		Human	PMID:12618434
Biological Process	GO:0016559	peroxisome fission	DNM1L	IMP		Human	PMID:18353969
Biological Process	GO:0016559	peroxisome fission	DNM1L	IMP		Human	PMID:23921378
Biological Process	GO:0043065	positive regulation of apoptotic process	DNM1L	IMP		Human	PMID:20850011
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Dnm1l	IMP		Rat	PMID:19605646|RGD:7800727
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	DNM1L	IMP		Human	PMID:20850011
Biological Process	GO:0090141	positive regulation of mitochondrial fission	DNM1L	IMP		Human	PMID:19279012
Biological Process	GO:0090141	positive regulation of mitochondrial fission	Dnm1l	IMP		Rat	PMID:17443673|RGD:12738363
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	DNM1L	IMP		Human	PMID:28388446
Biological Process	GO:0050714	positive regulation of protein secretion	DNM1L	IDA		Human	PMID:9570752
Biological Process	GO:0090200	positive regulation of release of cytochrome c from mitochondria	DNM1L	IMP		Human	PMID:21149567
Biological Process	GO:1900244	positive regulation of synaptic vesicle endocytosis	Dnm1l	IMP		Rat	PMID:23792689|RGD:12793033
Biological Process	GO:2000302	positive regulation of synaptic vesicle exocytosis	Dnm1l	IMP		Rat	PMID:23792689|RGD:12793033
Biological Process	GO:0051259	protein complex oligomerization	DNM1L	IMP		Human	PMID:27145208
Biological Process	GO:0070585	protein localization to mitochondrion	Dnm1l	IMP		Mouse	PMID:24515348
Biological Process	GO:0065003	protein-containing complex assembly	DNM1L	IDA		Human	PMID:20850011
Biological Process	GO:1903578	regulation of ATP metabolic process	Dnm1l	IMP		Mouse	MGI:MGI:4459561|PMID:20585624
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	DNM1L	IGI	UniProtKB:Q9BXM7	Human	PMID:19279012
Biological Process	GO:0010468	regulation of gene expression	Dnm1l	IMP	MGI:MGI:5312923	Mouse	PMID:28063983
Biological Process	GO:0010821	regulation of mitochondrion organization	DNM1L	IMP		Human	PMID:18353969
Biological Process	GO:0010821	regulation of mitochondrion organization	DNM1L	IMP		Human	PMID:21149567
Biological Process	GO:0010821	regulation of mitochondrion organization	Dnm1l	IMP		Mouse	MGI:MGI:4459561|PMID:20585624
Biological Process	GO:1900063	regulation of peroxisome organization	DNM1L	IMP		Human	PMID:18353969
Biological Process	GO:1900063	regulation of peroxisome organization	Dnm1l	IMP		Mouse	MGI:MGI:4459561|PMID:20585624
Biological Process	GO:1904666	regulation of ubiquitin protein ligase activity	Dnm1l	IMP	MGI:MGI:5312923	Mouse	PMID:28063983
Biological Process	GO:0001836	release of cytochrome c from mitochondria	DNM1L	IMP		Human	PMID:20850011
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Dnm1l	IMP		Rat	PMID:17443673|RGD:12738363
Biological Process	GO:1905395	response to flavonoid	Dnm1l	IEP		Rat	PMID:24637344|RGD:12738213
Biological Process	GO:1990910	response to hypobaric hypoxia	Dnm1l	IEP		Rat	PMID:24637344|RGD:12738213
Biological Process	GO:0048488	synaptic vesicle endocytosis	Dnm1l	IDA		Rat	PMID:23792689|RGD:12793033
Biological Process	GO:0048488	synaptic vesicle endocytosis	Dnm1l	IMP		Rat	PMID:23792689|RGD:12793033
Biological Process	GO:0036466	synaptic vesicle recycling via endosome	Dnm1l	IMP		Rat	PMID:23792689|RGD:12793033

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern