Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Dnm2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DNM2
- Mouse genes Dnm2
- Rat genes Dnm2
- Zfish genes dnm2a,dnm2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dnm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031749	D2 dopamine receptor binding	Dnm2	IPI	RGD:2520	Rat	PMID:14709338\|RGD:9685157
Molecular Function	GO:0003924	GTPase activity	Dnm2	IDA		Rat	PMID:21281588\|RGD:13504769
Molecular Function	GO:0050998	nitric-oxide synthase binding	Dnm2	IDA		Rat	PMID:21490139\|RGD:5131889
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Dnm2	IDA		Rat	PMID:12205083\|RGD:727418
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9UPX8	Human	PMID:11583995
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9Y566	Human	PMID:11583995
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9Y5X1	Human	PMID:15703209
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9P0V3	Human	PMID:16325581
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9UNF0	Human	PMID:16551695
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q14247	Human	PMID:16636290
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P62993	Human	PMID:16696976
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q15811	Human	PMID:16696976
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q99962	Human	PMID:16696976
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q12965	Human	PMID:17257598
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q99962	Human	PMID:17257598
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9QPN3	Human	PMID:17412836
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:O00499	Human	PMID:17676042
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9Y5X1	Human	PMID:18388313
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P62993	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q96B97	Human	PMID:20711168
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q15811	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P62993	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9UQB3	Human	PMID:22022388
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q8N157	Human	PMID:22623184
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P22392	Human	PMID:24970086
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P62993	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9Y5X1	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q96RF0	Human	PMID:29437695
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P62993	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:O76064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:O95817	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P47897	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P54646	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:P57075-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q15436	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q8NFF5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNM2	IPI	UniProtKB:Q9BUZ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Dnm2	IPI	UniProtKB:Q7TQF7	Mouse	MGI:MGI:5644011\|PMID:23640057
Molecular Function	GO:0005515	protein binding	Dnm2	IPI	UniProtKB:Q01406\|UniProtKB:Q60598	Mouse	MGI:MGI:5447630\|PMID:11018064
Molecular Function	GO:0005515	protein binding	Dnm2	IPI	PR:P09174	Mouse	PMID:11502744
Molecular Function	GO:0005515	protein binding	Dnm2	IPI	UniProtKB:O08838	Rat	PMID:16325581\|RGD:8554402
Molecular Function	GO:0005515	protein binding	Dnm2	IPI	UniProtKB:Q9P0V3	Rat	PMID:16325581\|RGD:8554402
Molecular Function	GO:0005515	protein binding	Dnm2	IPI	UniProtKB:Q9BX66	Rat	PMID:19116150\|RGD:8554820
Molecular Function	GO:0005515	protein binding	Dnm2	IPI	RGD:621145	Rat	PMID:19509061\|RGD:9685297
Molecular Function	GO:0005515	protein binding	Dnm2	IPI	UniProtKB:Q96B97	Rat	PMID:20711168\|RGD:8553899
Molecular Function	GO:0005515	protein binding	Dnm2	IPI	UniProtKB:Q9Z1P2	Rat	PMID:21210813\|RGD:10047315
Molecular Function	GO:0019901	protein kinase binding	Dnm2	IPI	RGD:620795	Rat	PMID:15007081\|RGD:1581140
Molecular Function	GO:0120283	protein serine/threonine kinase binding	Dnm2	IPI	RGD:620760	Rat	PMID:20802490\|RGD:152995511
Molecular Function	GO:0044877	protein-containing complex binding	Dnm2	IDA		Rat	PMID:17257598\|RGD:2312449
Molecular Function	GO:0017124	SH3 domain binding	DNM2	IDA		Human	PMID:18388313
Molecular Function	GO:0017124	SH3 domain binding	Dnm2	IPI	RGD:620274	Rat	PMID:19122684\|RGD:9685149
Molecular Function	GO:0050699	WW domain binding	Dnm2	IPI	RGD:1549750	Rat	PMID:23994472\|RGD:9685166
Cellular Component	GO:0030054	cell junction	Dnm2	IDA		Rat	PMID:21210813\|RGD:10047315
Cellular Component	GO:0005813	centrosome	Dnm2	IDA		Rat	PMID:23994472\|RGD:9685166
Cellular Component	GO:0045334	clathrin-coated endocytic vesicle	Dnm2	IDA		Rat	PMID:11925437\|RGD:728683
Cellular Component	GO:0005905	clathrin-coated pit	Dnm2	IDA		Mouse	PMID:26437238
Cellular Component	GO:0005905	clathrin-coated pit	Dnm2	IDA		Rat	PMID:19995918\|RGD:10047197
Cellular Component	GO:0005905	clathrin-coated pit	Dnm2	IDA		Rat	PMID:9725914\|RGD:9685132
Cellular Component	GO:0005737	cytoplasm	Dnm2	IDA		Rat	PMID:15126636\|RGD:8554781
Cellular Component	GO:0005829	cytosol	DNM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	DNM2	IDA		Human	PMID:18388313
Cellular Component	GO:0005768	endosome	Dnm2	IDA		Rat	PMID:12802072\|RGD:9685290
Cellular Component	GO:0070062	extracellular exosome	DNM2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	DNM2	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	DNM2	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Dnm2	IDA		Rat	PMID:11583995\|RGD:628513
Cellular Component	GO:0098978	glutamatergic synapse	Dnm2	IMP		Rat	PMID:11583995\|RGD:628513
Cellular Component	GO:0005794	Golgi apparatus	DNM2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	Dnm2	IDA		Rat	PMID:9725914\|RGD:9685132
Cellular Component	GO:0000139	Golgi membrane	Dnm2	IDA		Rat	PMID:15821732\|RGD:9685291
Cellular Component	GO:0030426	growth cone	Dnm2	IDA		Rat	PMID:21210813\|RGD:10047315
Cellular Component	GO:0030027	lamellipodium	Dnm2	IDA		Rat	PMID:9725914\|RGD:9685132
Cellular Component	GO:0005874	microtubule	DNM2	IDA		Human	PMID:21525035
Cellular Component	GO:0005634	nucleus	Dnm2	IDA		Rat	PMID:15942958\|RGD:1598733
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Dnm2	IDA		Rat	PMID:15126636\|RGD:8554781
Cellular Component	GO:0001891	phagocytic cup	Dnm2	IDA		Rat	PMID:12802072\|RGD:9685290
Cellular Component	GO:0001917	photoreceptor inner segment	Dnm2	IDA		Mouse	PMID:23746204
Cellular Component	GO:0005886	plasma membrane	Dnm2	IDA		Rat	PMID:9725914\|RGD:9685132
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Dnm2	IDA		Rat	PMID:11583995\|RGD:628513
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Dnm2	IMP		Rat	PMID:11583995\|RGD:628513
Cellular Component	GO:0045211	postsynaptic membrane	DNM2	IDA		Human	PMID:11583995
Cellular Component	GO:0098793	presynapse	Dnm2	IDA		Mouse	MGI:MGI:5285027\|PMID:21689597
Cellular Component	GO:0032991	protein-containing complex	Dnm2	IDA		Rat	PMID:17257598\|RGD:2312449
Cellular Component	GO:0032587	ruffle membrane	Dnm2	IDA		Rat	PMID:9725914\|RGD:9685132
Cellular Component	GO:0045202	synapse	Dnm2	IDA		Mouse	MGI:MGI:5285027\|PMID:21689597
Cellular Component	GO:0005802	trans-Golgi network	Dnm2	IDA		Rat	PMID:12802072\|RGD:9685290
Biological Process	GO:0035904	aorta development	Dnm2	IMP		Mouse	PMID:25807483
Biological Process	GO:0071245	cellular response to carbon monoxide	Dnm2	IEP		Rat	PMID:25100282\|RGD:9685289
Biological Process	GO:1903351	cellular response to dopamine	Dnm2	IDA		Rat	PMID:12205083\|RGD:727418
Biological Process	GO:0071732	cellular response to nitric oxide	Dnm2	IEP		Rat	PMID:25100282\|RGD:9685289
Biological Process	GO:0071481	cellular response to X-ray	Dnm2	IEP		Rat	PMID:15994918\|RGD:9685147
Biological Process	GO:0043009	chordate embryonic development	dnm2b	IMP	ZFIN:ZDB-MRPHLNO-130411-1	Zfish	PMID:23418470
Biological Process	GO:0043009	chordate embryonic development	dnm2a	IMP	ZFIN:ZDB-MRPHLNO-130411-2	Zfish	PMID:23418470
Biological Process	GO:0060026	convergent extension	dnm2a	IMP	ZFIN:ZDB-MRPHLNO-070712-5	Zfish	PMID:17412835
Biological Process	GO:0060026	convergent extension	dnm2a	IDA		Zfish	PMID:17412835
Biological Process	GO:0060976	coronary vasculature development	Dnm2	IMP		Mouse	PMID:25807483
Biological Process	GO:0006897	endocytosis	DNM2	IDA		Human	PMID:33713620
Biological Process	GO:0002031	G protein-coupled receptor internalization	Dnm2	IMP		Rat	PMID:14709338\|RGD:9685157
Biological Process	GO:0003094	glomerular filtration	dnm2b	IMP	ZFIN:ZDB-MRPHLNO-130411-2	Zfish	PMID:25962121
Biological Process	GO:0006893	Golgi to plasma membrane transport	Dnm2	IMP		Rat	PMID:20231454\|RGD:9685288
Biological Process	GO:0044351	macropinocytosis	Dnm2	IMP		Rat	PMID:18003703\|RGD:9685165
Biological Process	GO:0055001	muscle cell development	dnm2b	IMP	ZFIN:ZDB-MRPHLNO-070713-2	Zfish	PMID:23092955
Biological Process	GO:0061061	muscle structure development	dnm2a	IMP	ZFIN:ZDB-MRPHLNO-130411-1	Zfish	PMID:23418470
Biological Process	GO:1903526	negative regulation of membrane tubulation	DNM2	IDA		Human	PMID:18388313
Biological Process	GO:1902856	negative regulation of non-motile cilium assembly	Dnm2	IMP		Rat	PMID:23994472\|RGD:9685166
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Dnm2	IMP		Rat	PMID:25100282\|RGD:9685289
Biological Process	GO:0048812	neuron projection morphogenesis	Dnm2	IMP		Rat	PMID:21210813\|RGD:10047315
Biological Process	GO:0072015	podocyte development	dnm2b	IMP	ZFIN:ZDB-MRPHLNO-130411-2	Zfish	PMID:25962121
Biological Process	GO:2000370	positive regulation of clathrin-dependent endocytosis	Dnm2	IMP		Rat	PMID:11925437\|RGD:728683
Biological Process	GO:0045807	positive regulation of endocytosis	Dnm2	IMP		Rat	PMID:18435821\|RGD:9685294
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	Dnm2	IMP		Rat	PMID:14617821\|RGD:9685179
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	Dnm2	IMP		Rat	PMID:16973909\|RGD:9685181
Biological Process	GO:1903408	positive regulation of P-type sodium:potassium-exchanging transporter activity	Dnm2	IMP		Rat	PMID:12205083\|RGD:727418
Biological Process	GO:0050766	positive regulation of phagocytosis	Dnm2	IMP		Rat	PMID:12802072\|RGD:9685290
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Dnm2	IMP		Rat	PMID:14617821\|RGD:9685179
Biological Process	GO:0031623	receptor internalization	DNM2	IMP		Human	PMID:14985334
Biological Process	GO:0006898	receptor-mediated endocytosis	Dnm2	IDA		Rat	PMID:11925437\|RGD:728683
Biological Process	GO:0006898	receptor-mediated endocytosis	Dnm2	IMP		Rat	PMID:19995918\|RGD:10047197
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	dnm2b	IMP	ZFIN:ZDB-MRPHLNO-130411-2	Zfish	PMID:25962121
Biological Process	GO:0030516	regulation of axon extension	Dnm2	IMP		Rat	PMID:21210813\|RGD:10047315
Biological Process	GO:1903358	regulation of Golgi organization	Dnm2	IMP		Rat	PMID:20231454\|RGD:9685288
Biological Process	GO:0035020	regulation of Rac protein signal transduction	Dnm2	IMP		Rat	PMID:14617821\|RGD:9685179
Biological Process	GO:0042220	response to cocaine	Dnm2	IEP		Rat	PMID:19562697\|RGD:9685177
Biological Process	GO:0009416	response to light stimulus	Dnm2	IEP		Rat	PMID:22666495\|RGD:9685159
Biological Process	GO:0061053	somite development	dnm2a	IMP	ZFIN:ZDB-MRPHLNO-160427-4	Zfish	PMID:26842864
Biological Process	GO:0061053	somite development	dnm2a	IMP	ZFIN:ZDB-MRPHLNO-160427-3	Zfish	PMID:26842864
Biological Process	GO:0007283	spermatogenesis	Dnm2	IEP		Rat	PMID:12199526\|RGD:9685158
Biological Process	GO:0048488	synaptic vesicle endocytosis	Dnm2	IDA		Mouse	PMID:21689597
Biological Process	GO:0048488	synaptic vesicle endocytosis	Dnm2	IMP		Mouse	PMID:21689597
Biological Process	GO:0033572	transferrin transport	DNM2	IMP		Human	PMID:14985334
Biological Process	GO:0003281	ventricular septum development	Dnm2	IMP		Mouse	PMID:25807483

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.