Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DNMT1
  • Mouse genes Dnmt1
  • Rat genes Dnmt1
  • Zfish genes dnmt1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dnmt1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Dnmt1	IDA		Mouse	PMID:24105743
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	DNMT1	IDA		Human	PMID:21745816
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Dnmt1	IDA		Mouse	PMID:11399088
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Dnmt1	IDA		Rat	PMID:12473678|RGD:1359078
Molecular Function	GO:0051718	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:25886310
Molecular Function	GO:0003677	DNA binding	DNMT1	IDA		Human	PMID:18754681
Molecular Function	GO:0003677	DNA binding	Dnmt1	IDA		Mouse	PMID:11399088
Molecular Function	GO:0009008	DNA-methyltransferase activity	DNMT1	IDA		Human	PMID:18754681
Molecular Function	GO:0042826	histone deacetylase binding	Dnmt1	IPI	RGD:1320331	Rat	PMID:12473678|RGD:1359078
Molecular Function	GO:0008327	methyl-CpG binding	Dnmt1	IDA		Mouse	PMID:20573698
Molecular Function	GO:0008168	methyltransferase activity	Dnmt1	IDA		Mouse	MGI:MGI:3687778|PMID:10615135
Molecular Function	GO:0030331	nuclear estrogen receptor binding	Dnmt1	IPI	RGD:2582	Rat	PMID:19683557|RGD:8694315
Molecular Function	GO:1990841	promoter-specific chromatin binding	DNMT1	IDA		Human	PMID:24623306
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:O75530	Human	PMID:16357870
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q15910	Human	PMID:16357870
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q9QR71	Human	PMID:16983096
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q96T88	Human	PMID:17673620
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q96T88	Human	PMID:17934516
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:P48552	Human	PMID:17972916
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q8WTS6	Human	PMID:19282482
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:P63279	Human	PMID:19450230
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q96T88	Human	PMID:19798101
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:P31749	Human	PMID:21151116
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q8WTS6	Human	PMID:21151116
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q9NRD5	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q93009	Human	PMID:21745816
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q96EB6	Human	PMID:21947282
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:O75530	Human	PMID:22094255
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q15910	Human	PMID:22094255
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q96EB6	Human	PMID:22094255
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:A8MW92	Human	PMID:24492612
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q77UV9	Human	PMID:25544563
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:P35222	Human	PMID:25753001
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:P09874	Human	PMID:27728808
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q96JK2	Human	PMID:29691401
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:Q96JM7	Human	PMID:29691401
Molecular Function	GO:0005515	protein binding	DNMT1	IPI	UniProtKB:O14978	Human	PMID:32051553
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	UniProtKB:Q6A4J8	Mouse	MGI:MGI:5442500|PMID:21268065
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	UniProtKB:Q91YE5	Mouse	MGI:MGI:3587127|PMID:16085498
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	UniProtKB:Q8VDF2	Mouse	MGI:MGI:3768689|PMID:17994007
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	UniProtKB:P12004	Mouse	MGI:MGI:4441123|PMID:15550930
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	UniProtKB:O09106	Mouse	MGI:MGI:3687778|PMID:10615135
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	UniProtKB:Q61658	Mouse	PMID:17931718
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	PR:A2BH40	Mouse	PMID:24335282
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	PR:Q61658	Mouse	PMID:17931718
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	PR:P17918	Mouse	PMID:10888872
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	PR:Q9JI44	Mouse	PMID:10888872
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	PR:P70288	Mouse	PMID:10888872
Molecular Function	GO:0005515	protein binding	Dnmt1	IPI	RGD:1302972	Rat	PMID:22880885|RGD:9588218
Molecular Function	GO:0019904	protein domain specific binding	Dnmt1	IPI	RGD:3075	Rat	PMID:12473678|RGD:1359078
Molecular Function	GO:0003723	RNA binding	Dnmt1	IDA		Mouse	PMID:20573698
Molecular Function	GO:0008270	zinc ion binding	Dnmt1	IDA		Mouse	PMID:11399088
Cellular Component	GO:0005737	cytoplasm	Dnmt1	IDA		Rat	PMID:19660178|RGD:9588289
Cellular Component	GO:0001674	female germ cell nucleus	Dnmt1	IDA		Mouse	PMID:15063176
Cellular Component	GO:0043073	germ cell nucleus	Dnmt1	IDA		Mouse	PMID:15063176
Cellular Component	GO:0000792	heterochromatin	Dnmt1	IDA		Mouse	PMID:14519686
Cellular Component	GO:0005634	nucleus	DNMT1	HDA		Human	PMID:16791210
Cellular Component	GO:0005634	nucleus	Dnmt1	IDA		Mouse	PMID:16424344
Cellular Component	GO:0005634	nucleus	Dnmt1	IDA		Mouse	PMID:17931718
Cellular Component	GO:0005634	nucleus	Dnmt1	IDA		Mouse	PMID:11942627
Cellular Component	GO:0005634	nucleus	Dnmt1	IDA		Rat	PMID:12473678|RGD:1359078
Cellular Component	GO:0005634	nucleus	Dnmt1	IDA		Rat	PMID:3856245|RGD:2301219
Cellular Component	GO:0005721	pericentric heterochromatin	Dnmt1	IDA		Mouse	MGI:MGI:3852629|PMID:17576694
Cellular Component	GO:0032991	protein-containing complex	Dnmt1	IDA		Rat	PMID:12473678|RGD:1359078
Cellular Component	GO:0005657	replication fork	Dnmt1	IDA		Mouse	PMID:10888872
Biological Process	GO:0007568	aging	Dnmt1	IEP		Rat	PMID:16702315|RGD:9588248
Biological Process	GO:0030183	B cell differentiation	dnmt1	IMP	ZFIN:ZDB-GENO-210917-1	Zfish	PMID:32585597
Biological Process	GO:0007420	brain development	Dnmt1	IEP		Rat	PMID:23954679|RGD:9588223
Biological Process	GO:0051216	cartilage development	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:19946145
Biological Process	GO:0071230	cellular response to amino acid stimulus	Dnmt1	IDA		Mouse	PMID:20548288
Biological Process	GO:1903926	cellular response to bisphenol A	Dnmt1	IDA		Mouse	PMID:21980460
Biological Process	GO:0071284	cellular response to lead ion	Dnmt1	IEP		Rat	PMID:22764079|RGD:9588241
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Dnmt1	IEP		Rat	PMID:10407183|RGD:9588607
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Dnmt1	IEP		Rat	PMID:23423710|RGD:9588226
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Dnmt1	IMP		Rat	PMID:24211420|RGD:9588224
Biological Process	GO:0060216	definitive hemopoiesis	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-150720-1	Zfish	PMID:25886310
Biological Process	GO:0060216	definitive hemopoiesis	dnmt1	IGI	ZFIN:ZDB-GENE-020111-2	Zfish	PMID:25886310
Biological Process	GO:0060216	definitive hemopoiesis	dnmt1	IMP	ZFIN:ZDB-GENO-170608-2	Zfish	PMID:25886310
Biological Process	GO:0060216	definitive hemopoiesis	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:25886310
Biological Process	GO:0007368	determination of left/right symmetry	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:28882847
Biological Process	GO:0007368	determination of left/right symmetry	dnmt1	IGI	ZFIN:ZDB-MRPHLNO-050809-6,ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:28882847
Biological Process	GO:0048565	digestive tract development	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:19946145
Biological Process	GO:0006306	DNA methylation	Dnmt1	IMP		Mouse	PMID:27892467
Biological Process	GO:0006306	DNA methylation	Dnmt1	IGI	MGI:MGI:1261819,MGI:MGI:1261827	Mouse	PMID:27841881
Biological Process	GO:0006306	DNA methylation	Dnmt1	IMP	MGI:MGI:1930971	Mouse	PMID:16887828
Biological Process	GO:0006306	DNA methylation	Dnmt1	IMP		Mouse	PMID:24105743
Biological Process	GO:0006306	DNA methylation	Dnmt1	IDA		Mouse	PMID:11399088
Biological Process	GO:0006306	DNA methylation	Dnmt1	IEP		Rat	PMID:21682946|RGD:9588311
Biological Process	GO:0006306	DNA methylation	dnmt1	IMP		Zfish	PMID:25886310
Biological Process	GO:0006306	DNA methylation	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-050809-1	Zfish	PMID:15937923
Biological Process	GO:0006306	DNA methylation	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:28882847
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt1	IMP	MGI:MGI:3613486,MGI:MGI:5566775	Mouse	PMID:29117290
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt1	IGI	MGI:MGI:1261819,MGI:MGI:1261827	Mouse	PMID:27841881
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt1	IMP	MGI:MGI:1857157	Mouse	PMID:1606615
Biological Process	GO:0032776	DNA methylation on cytosine	Dnmt1	IMP	MGI:MGI:1857157	Mouse	PMID:1606615
Biological Process	GO:0032776	DNA methylation on cytosine	Dnmt1	IDA		Rat	PMID:22880885|RGD:9588218
Biological Process	GO:0032776	DNA methylation on cytosine	dnmt1	IMP	ZFIN:ZDB-GENO-210917-1	Zfish	PMID:32585597
Biological Process	GO:0032776	DNA methylation on cytosine	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-120517-15,ZFIN:ZDB-MRPHLNO-120517-16	Zfish	PMID:21319190
Biological Process	GO:0032776	DNA methylation on cytosine	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:16980612
Biological Process	GO:0032776	DNA methylation on cytosine	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:19946145
Biological Process	GO:0010424	DNA methylation on cytosine within a CG sequence	Dnmt1	IDA		Rat	PMID:3856245|RGD:2301219
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	Dnmt1	IDA		Mouse	MGI:MGI:3687778|PMID:10615135
Biological Process	GO:0006351	DNA-templated transcription	Dnmt1	IMP	MGI:MGI:2156895	Mouse	PMID:17245608
Biological Process	GO:0031017	exocrine pancreas development	dnmt1	IMP	ZFIN:ZDB-GENO-080808-1	Zfish	PMID:19631206
Biological Process	GO:0031017	exocrine pancreas development	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:16980612
Biological Process	GO:0031017	exocrine pancreas development	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:19946145
Biological Process	GO:0031017	exocrine pancreas development	dnmt1	IMP	ZFIN:ZDB-GENO-100112-13	Zfish	PMID:19631206
Biological Process	GO:0030851	granulocyte differentiation	dnmt1	IMP	ZFIN:ZDB-GENO-170608-2	Zfish	PMID:25886310
Biological Process	GO:0030851	granulocyte differentiation	dnmt1	IGI	ZFIN:ZDB-GENE-020111-2	Zfish	PMID:25886310
Biological Process	GO:0030851	granulocyte differentiation	dnmt1	IMP		Zfish	PMID:25886310
Biological Process	GO:0030851	granulocyte differentiation	dnmt1	IGI	ZFIN:ZDB-GENE-990714-15	Zfish	PMID:25886310
Biological Process	GO:0051567	histone H3-K9 methylation	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:16980612
Biological Process	GO:0035622	intrahepatic bile duct development	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-120517-15,ZFIN:ZDB-MRPHLNO-120517-16	Zfish	PMID:21319190
Biological Process	GO:0035622	intrahepatic bile duct development	dnmt1	IMP	ZFIN:ZDB-GENO-050816-6	Zfish	PMID:21319190
Biological Process	GO:0070121	Kupffer's vesicle development	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:28882847
Biological Process	GO:0002088	lens development in camera-type eye	dnmt1	IMP	ZFIN:ZDB-GENO-100112-13	Zfish	PMID:21126517
Biological Process	GO:0001889	liver development	dnmt1	IMP	ZFIN:ZDB-GENO-170608-2	Zfish	PMID:25886310
Biological Process	GO:0001889	liver development	dnmt1	IGI	ZFIN:ZDB-GENE-040426-2039	Zfish	PMID:25564650
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Dnmt1	IMP	MGI:MGI:2156895	Mouse	PMID:17245608
Biological Process	GO:0010629	negative regulation of gene expression	DNMT1	IMP		Human	PMID:27021683
Biological Process	GO:0010629	negative regulation of gene expression	Dnmt1	IMP	MGI:MGI:3613486,MGI:MGI:5566775	Mouse	PMID:29117290
Biological Process	GO:0010629	negative regulation of gene expression	dnmt1	IMP	ZFIN:ZDB-GENO-170608-2	Zfish	PMID:25886310
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	DNMT1	IDA		Human	PMID:18754681
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	DNMT1	IDA		Human	PMID:21745816
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	DNMT1	IMP		Human	PMID:24623306
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	Dnmt1	IMP		Mouse	MGI:MGI:3852629|PMID:17576694
Biological Process	GO:0044027	negative regulation of gene expression via CpG island methylation	Dnmt1	IDA		Rat	PMID:12473678|RGD:1359078
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dnmt1	IDA		Mouse	PMID:10888872
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dnmt1	IMP	MGI:MGI:1930971	Mouse	PMID:16887828
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dnmt1	IMP		Mouse	PMID:24105743
Biological Process	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	DNMT1	IMP		Human	PMID:27021683
Biological Process	GO:1905931	negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	DNMT1	IMP		Human	PMID:27021683
Biological Process	GO:0030182	neuron differentiation	Dnmt1	IEP		Rat	PMID:19660178|RGD:9588289
Biological Process	GO:0031016	pancreas development	dnmt1	IMP	ZFIN:ZDB-GENO-170608-2	Zfish	PMID:25886310
Biological Process	GO:0010628	positive regulation of gene expression	DNMT1	IMP		Human	PMID:18413740
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	DNMT1	IMP		Human	PMID:27021683
Biological Process	GO:0042127	regulation of cell population proliferation	Dnmt1	IGI	MGI:MGI:88039	Mouse	PMID:10919675
Biological Process	GO:0042127	regulation of cell population proliferation	Dnmt1	IGI	MGI:MGI:104642	Mouse	PMID:10919675
Biological Process	GO:0044030	regulation of DNA methylation	dnmt1	IMP	ZFIN:ZDB-GENO-100112-13	Zfish	PMID:19631206
Biological Process	GO:0044030	regulation of DNA methylation	dnmt1	IMP	ZFIN:ZDB-GENO-080808-1	Zfish	PMID:19631206
Biological Process	GO:0010468	regulation of gene expression	Dnmt1	IMP	MGI:MGI:2156895	Mouse	PMID:16491076
Biological Process	GO:0010468	regulation of gene expression	Dnmt1	IMP		Mouse	PMID:23028046
Biological Process	GO:0014823	response to activity	Dnmt1	IEP		Rat	PMID:23201423|RGD:9588254
Biological Process	GO:0031000	response to caffeine	Dnmt1	IEP		Rat	PMID:24717552|RGD:9590296
Biological Process	GO:0032355	response to estradiol	Dnmt1	IEP		Rat	PMID:22334722|RGD:9588258
Biological Process	GO:0045471	response to ethanol	Dnmt1	IEP		Rat	PMID:24968059|RGD:9588611
Biological Process	GO:0009408	response to heat	Dnmt1	IEP		Rat	PMID:24270982|RGD:9588227
Biological Process	GO:0010212	response to ionizing radiation	Dnmt1	IEP		Rat	PMID:17148264|RGD:1601086
Biological Process	GO:0010288	response to lead ion	Dnmt1	IEP		Rat	PMID:23246732|RGD:9588316
Biological Process	GO:0032496	response to lipopolysaccharide	Dnmt1	IEP		Rat	PMID:23271618|RGD:9588621
Biological Process	GO:0031667	response to nutrient levels	Dnmt1	IEP		Rat	PMID:24270982|RGD:9588227
Biological Process	GO:0010033	response to organic substance	Dnmt1	IEP		Rat	PMID:23791455|RGD:9588229
Biological Process	GO:0033574	response to testosterone	Dnmt1	IEP		Rat	PMID:20056826|RGD:9588290
Biological Process	GO:0009636	response to toxic substance	Dnmt1	IEP		Rat	PMID:23433207|RGD:9588261
Biological Process	GO:0033189	response to vitamin A	Dnmt1	IEP		Rat	PMID:23333085|RGD:9588314
Biological Process	GO:0009410	response to xenobiotic stimulus	Dnmt1	IEP		Rat	PMID:16632870|RGD:1601088
Biological Process	GO:0009410	response to xenobiotic stimulus	Dnmt1	IDA		Rat	PMID:22880885|RGD:9588218
Biological Process	GO:0009410	response to xenobiotic stimulus	Dnmt1	IMP		Rat	PMID:32051532|RGD:126925233
Biological Process	GO:0010842	retina layer formation	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:19946145
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	dnmt1	IMP	ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:16980612
Biological Process	GO:0046500	S-adenosylmethionine metabolic process	Dnmt1	IDA		Rat	PMID:3856245|RGD:2301219
Biological Process	GO:0033077	T cell differentiation in thymus	dnmt1	IMP	ZFIN:ZDB-GENO-210917-1	Zfish	PMID:32585597

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern