Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Dnmt3b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DNMT3B
- Mouse genes Dnmt3b
- Rat genes Dnmt3b
- Zfish genes dnmt3ba,dnmt3bb.1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dnmt3b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Dnmt3b	IDA		Rat	PMID:23671328\|RGD:9590112
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	DNMT3B	IDA		Human	PMID:16543361
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Dnmt3b	IDA		Mouse	PMID:16543361
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Dnmt3b	IGI	MGI:MGI:1261827	Mouse	PMID:17938196
Molecular Function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Dnmt3b	IDA		Mouse	PMID:9662389
Molecular Function	GO:0051718	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	Dnmt3b	IDA		Mouse	PMID:27856912
Molecular Function	GO:0003677	DNA binding	Dnmt3b	IDA		Mouse	PMID:21378119
Molecular Function	GO:0003677	DNA binding	Dnmt3b	IDA		Rat	PMID:16537533\|RGD:1601089
Molecular Function	GO:0042826	histone deacetylase binding	Dnmt3b	IPI	RGD:619976	Rat	PMID:15632075\|RGD:1601090
Molecular Function	GO:0008168	methyltransferase activity	Dnmt3b	IDA		Mouse	MGI:MGI:3852314\|PMID:11919202
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:P63165	Human	PMID:11735126
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:P63279	Human	PMID:11735126
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:O75530	Human	PMID:16357870
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:Q15910	Human	PMID:16357870
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:Q9QR71	Human	PMID:16983096
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:Q9UKY1	Human	PMID:17303076
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:Q96KQ7	Human	PMID:18953337
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:Q96T88	Human	PMID:19798101
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:O75530	Human	PMID:22094255
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:Q15910	Human	PMID:22094255
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:Q15910	Human	PMID:24074865
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:Q15910	Human	PMID:27728808
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:Q9Y6K1	Human	PMID:32968275
Molecular Function	GO:0005515	protein binding	DNMT3B	IPI	UniProtKB:P63165	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	UniProtKB:Q9CWR8	Mouse	MGI:MGI:5553039\|PMID:24074865
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	UniProtKB:O00257	Mouse	MGI:MGI:3852300\|PMID:18567530
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	UniProtKB:Q9CWR8	Mouse	MGI:MGI:3719491\|PMID:17687327
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	UniProtKB:Q9Z148-2	Mouse	MGI:MGI:5915592\|PMID:18953337
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	UniProtKB:Q91YE5	Mouse	MGI:MGI:3587127\|PMID:16085498
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	UniProtKB:Q60848	Mouse	MGI:MGI:5508259\|PMID:16395332
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	UniProtKB:P25916	Mouse	MGI:MGI:6092708\|PMID:17726103
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	PR:Q9CWR8	Mouse	PMID:17938196
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	PR:Q9CZJ6	Mouse	PMID:22516971
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	PR:Q9CWR8	Mouse	PMID:11934864
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	PR:Q9CWR8	Mouse	PMID:16543361
Molecular Function	GO:0005515	protein binding	Dnmt3b	IPI	RGD:2741	Rat	PMID:23671328\|RGD:9590112
Molecular Function	GO:0003714	transcription corepressor activity	DNMT3B	IDA		Human	PMID:17303076
Molecular Function	GO:0003714	transcription corepressor activity	DNMT3B	IMP		Human	PMID:18567530
Cellular Component	GO:1902494	catalytic complex	DNMT3B	IPI		Human	PMID:32083663
Cellular Component	GO:0000775	chromosome, centromeric region	Dnmt3b	IDA		Mouse	MGI:MGI:3056853\|PMID:15456878
Cellular Component	GO:0005737	cytoplasm	Dnmt3b	IDA		Rat	PMID:11844796\|RGD:2289670
Cellular Component	GO:0000792	heterochromatin	Dnmt3b	IDA		Mouse	PMID:14519686
Cellular Component	GO:0000792	heterochromatin	Dnmt3b	IDA		Mouse	PMID:16543361
Cellular Component	GO:0000792	heterochromatin	Dnmt3b	IDA		Mouse	PMID:11934864
Cellular Component	GO:0005654	nucleoplasm	DNMT3B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DNMT3B	IDA		Human	PMID:17303076
Cellular Component	GO:0005634	nucleus	Dnmt3b	IDA		Mouse	PMID:16543361
Cellular Component	GO:0005634	nucleus	Dnmt3b	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Dnmt3b	IDA		Rat	PMID:11844796\|RGD:2289670
Cellular Component	GO:0005634	nucleus	Dnmt3b	IDA		Rat	PMID:15632075\|RGD:1601090
Biological Process	GO:0090116	C-5 methylation of cytosine	DNMT3B	IDA		Human	PMID:32083663
Biological Process	GO:0090116	C-5 methylation of cytosine	Dnmt3b	IDA		Mouse	PMID:27856912
Biological Process	GO:0071230	cellular response to amino acid stimulus	Dnmt3b	IDA		Mouse	PMID:20548288
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Dnmt3b	IEP		Rat	PMID:23671328\|RGD:9590112
Biological Process	GO:0071455	cellular response to hyperoxia	Dnmt3b	IEP		Rat	PMID:23039253\|RGD:9589076
Biological Process	GO:0060271	cilium assembly	dnmt3bb.1	IMP	ZFIN:ZDB-MRPHLNO-050809-6,ZFIN:ZDB-MRPHLNO-160406-1	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	dnmt3bb.1	IMP	ZFIN:ZDB-GENO-210129-1	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	dnmt3ba	IMP	ZFIN:ZDB-GENO-210129-3	Zfish	PMID:31513014
Biological Process	GO:0007368	determination of left/right symmetry	dnmt3bb.1	IGI	ZFIN:ZDB-MRPHLNO-050809-6,ZFIN:ZDB-MRPHLNO-070615-4	Zfish	PMID:28882847
Biological Process	GO:0007368	determination of left/right symmetry	dnmt3bb.1	IMP	ZFIN:ZDB-GENO-180831-8	Zfish	PMID:28882847
Biological Process	GO:0007368	determination of left/right symmetry	dnmt3bb.1	IMP	ZFIN:ZDB-MRPHLNO-050809-6	Zfish	PMID:28882847
Biological Process	GO:0006306	DNA methylation	Dnmt3b	IMP	MGI:MGI:3047833	Mouse	PMID:22133874
Biological Process	GO:0006306	DNA methylation	Dnmt3b	IGI	MGI:MGI:1859287	Mouse	PMID:16543361
Biological Process	GO:0006306	DNA methylation	Dnmt3b	IGI	MGI:MGI:1261827,MGI:MGI:94912	Mouse	PMID:27841881
Biological Process	GO:0006306	DNA methylation	Dnmt3b	IGI	MGI:MGI:1261827	Mouse	PMID:17938196
Biological Process	GO:0006306	DNA methylation	dnmt3ba	IMP	ZFIN:ZDB-MRPHLNO-050809-10	Zfish	PMID:15937923
Biological Process	GO:0006306	DNA methylation	dnmt3ba	IMP	ZFIN:ZDB-MRPHLNO-050809-9	Zfish	PMID:15937923
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt3b	IEP		Mouse	MGI:MGI:3826753\|PMID:18814855
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt3b	IGI	MGI:MGI:1261827	Mouse	PMID:10555141
Biological Process	GO:0043045	DNA methylation involved in embryo development	Dnmt3b	IGI	MGI:MGI:1261827,MGI:MGI:94912	Mouse	PMID:27841881
Biological Process	GO:0010424	DNA methylation on cytosine within a CG sequence	dnmt3bb.1	IMP	ZFIN:ZDB-MRPHLNO-160406-1	Zfish	PMID:26814702
Biological Process	GO:0006346	DNA methylation-dependent heterochromatin formation	Dnmt3b	IGI	MGI:MGI:1261827	Mouse	PMID:17938196
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	dnmt3bb.1	IMP	ZFIN:ZDB-GENO-160713-5	Zfish	PMID:26814702
Biological Process	GO:0070121	Kupffer's vesicle development	dnmt3bb.1	IMP	ZFIN:ZDB-MRPHLNO-050809-6,ZFIN:ZDB-MRPHLNO-160406-1	Zfish	PMID:31513014
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Dnmt3b	IMP		Rat	PMID:16537533\|RGD:1601089
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	Dnmt3b	IMP		Mouse	MGI:MGI:3765099\|PMID:18056424
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DNMT3B	IDA		Human	PMID:17303076
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Dnmt3b	IMP	MGI:MGI:3047833	Mouse	PMID:22133874
Biological Process	GO:0010628	positive regulation of gene expression	DNMT3B	IMP		Human	PMID:18413740
Biological Process	GO:0045666	positive regulation of neuron differentiation	Dnmt3b	IMP		Rat	PMID:15632075\|RGD:1601090
Biological Process	GO:0031503	protein-containing complex localization	Dnmt3b	IDA		Mouse	PMID:16543361
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Dnmt3b	IMP	MGI:MGI:2182410	Mouse	PMID:11934864
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	Dnmt3b	IMP	MGI:MGI:2182414	Mouse	PMID:11934864
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	dnmt3bb.1	IMP	ZFIN:ZDB-GENO-160713-5	Zfish	PMID:26814702
Biological Process	GO:0014823	response to activity	Dnmt3b	IEP		Rat	PMID:23201423\|RGD:9588254
Biological Process	GO:0031000	response to caffeine	Dnmt3b	IEP		Rat	PMID:24717552\|RGD:9590296
Biological Process	GO:0042220	response to cocaine	Dnmt3b	IEP		Rat	PMID:23688924\|RGD:9589062
Biological Process	GO:0032355	response to estradiol	Dnmt3b	IEP		Rat	PMID:22334722\|RGD:9588258
Biological Process	GO:0001666	response to hypoxia	Dnmt3b	IEP		Rat	PMID:23529784\|RGD:9588317
Biological Process	GO:0010212	response to ionizing radiation	Dnmt3b	IEP		Rat	PMID:17148264\|RGD:1601086
Biological Process	GO:0009636	response to toxic substance	Dnmt3b	IEP		Rat	PMID:23433207\|RGD:9588261
Biological Process	GO:0033189	response to vitamin A	Dnmt3b	IEP		Rat	PMID:23333085\|RGD:9588314
Biological Process	GO:0009410	response to xenobiotic stimulus	Dnmt3b	IEP		Rat	PMID:16632870\|RGD:1601088

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.