Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DOCK2
  • Mouse genes Dock2
  • Rat genes Dock2
  • Zfish genes dock2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dock2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	DOCK2	IDA		Human	PMID:10559471
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P63000	Human	PMID:12134158
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P63000	Human	PMID:15723800
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:O15162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:O95273	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P26371	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P36406	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P60411	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P61978	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q13137	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q5JR59	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q5VWX1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q9BYQ2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q9BYQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q9BYR5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:A6NEM1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:O75525	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:O76011	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P22735	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P26371	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P60328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P60409	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:P61978-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q07627	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q15323	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q5JR59-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q5VWX1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q6A162	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q6L8G8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q6N022	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q92824-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q9BWT7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q9BYP8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q9BYQ3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q9BYR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q9BYR8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK2	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0042608	T cell receptor binding	DOCK2	IDA		Human	PMID:12176041
Cellular Component	GO:0070062	extracellular exosome	DOCK2	HDA		Human	PMID:20458337
Cellular Component	GO:0016020	membrane	DOCK2	HDA		Human	PMID:19946888
Biological Process	GO:0046631	alpha-beta T cell activation	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644
Biological Process	GO:0046633	alpha-beta T cell proliferation	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644
Biological Process	GO:0006935	chemotaxis	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:11518968
Biological Process	GO:0007010	cytoskeleton organization	Dock2	IDA		Mouse	PMID:11518968
Biological Process	GO:0001768	establishment of T cell polarity	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644
Biological Process	GO:0001771	immunological synapse formation	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644
Biological Process	GO:0044351	macropinocytosis	Dock2	IMP		Mouse	MGI:MGI:5291858|PMID:21892172
Biological Process	GO:0001766	membrane raft polarization	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644
Biological Process	GO:0002277	myeloid dendritic cell activation involved in immune response	Dock2	IMP		Mouse	MGI:MGI:5291858|PMID:21892172
Biological Process	GO:0045060	negative thymic T cell selection	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644
Biological Process	GO:0050766	positive regulation of phagocytosis	Dock2	IMP		Mouse	MGI:MGI:5291858|PMID:21892172
Biological Process	GO:0045059	positive thymic T cell selection	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644
Biological Process	GO:0042110	T cell activation	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644
Biological Process	GO:0042098	T cell proliferation	Dock2	IMP	MGI:MGI:2152031	Mouse	PMID:12871644

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern