Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DOT1L
  • Mouse genes Dot1l
  • Rat genes Dot1l
  • Zfish genes dot1l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dot1l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042054	histone methyltransferase activity	DOT1L	IDA		Human	PMID:15851025
Molecular Function	GO:0042054	histone methyltransferase activity	DOT1L	IDA		Human	PMID:17707234
Molecular Function	GO:0042054	histone methyltransferase activity	Dot1l	IDA		Mouse	PMID:14572310
Molecular Function	GO:0003676	nucleic acid binding	DOT1L	EXP		Human	PMID:12628190
Molecular Function	GO:0005515	protein binding	DOT1L	IPI	UniProtKB:P42568	Human	PMID:20153263
Molecular Function	GO:0005515	protein binding	DOT1L	IPI	UniProtKB:Q03111	Human	PMID:20153263
Molecular Function	GO:0005515	protein binding	DOT1L	IPI	UniProtKB:P42568	Human	PMID:20203130
Molecular Function	GO:0005515	protein binding	DOT1L	IPI	UniProtKB:Q03111	Human	PMID:20203130
Molecular Function	GO:0005515	protein binding	DOT1L	IPI	UniProtKB:P42568	Human	PMID:23260655
Molecular Function	GO:0005515	protein binding	DOT1L	IPI	UniProtKB:P42568	Human	PMID:26496610
Cellular Component	GO:0005737	cytoplasm	Dot1l	IDA		Mouse	PMID:20427473
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	DOT1L	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	DOT1L	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DOT1L	IDA		Human	PMID:15851025
Cellular Component	GO:0005634	nucleus	Dot1l	IDA		Mouse	PMID:20427473
Cellular Component	GO:0032991	protein-containing complex	DOT1L	IDA		Human	PMID:15851025
Biological Process	GO:0060070	canonical Wnt signaling pathway	dot1l	IMP	ZFIN:ZDB-MRPHLNO-101207-7	Zfish	PMID:21103407
Biological Process	GO:0010467	gene expression	Dot1l	IMP		Mouse	PMID:20427473
Biological Process	GO:0010467	gene expression	Dot1l	IDA		Mouse	PMID:20427473
Biological Process	GO:0034729	histone H3-K79 methylation	DOT1L	IDA		Human	PMID:15851025
Biological Process	GO:0060729	intestinal epithelial structure maintenance	dot1l	IMP	ZFIN:ZDB-MRPHLNO-101207-7,ZFIN:ZDB-MRPHLNO-101207-8	Zfish	PMID:21103407
Biological Process	GO:0008284	positive regulation of cell population proliferation	DOT1L	IDA		Human	PMID:15851025
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DOT1L	IDA		Human	PMID:15851025
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DOT1L	IMP		Human	PMID:22002246
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	DOT1L	IDA		Human	PMID:22002246
Biological Process	GO:2000677	regulation of transcription regulatory region DNA binding	DOT1L	IMP		Human	PMID:22002246

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern