Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DPYD
  • Mouse genes Dpyd
  • Rat genes Dpyd
  • Zfish genes dpyda.1,dpydb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dpyd

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	DPYD	IDA		Human	PMID:10410956
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	DPYD	IMP		Human	PMID:11988088
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	DPYD	IDA		Human	PMID:1512248
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	DPYD	IDA		Human	PMID:18075467
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Dpyd	IDA		Mouse	PMID:5472365
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Dpyd	IDA		Mouse	PMID:12651209
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Dpyd	IDA		Rat	PMID:1544906|RGD:11251743
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Dpyd	IDA		Rat	PMID:7626590|RGD:1624989
Molecular Function	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Dpyd	IDA		Rat	PMID:8373446|RGD:8553278
Molecular Function	GO:0071949	FAD binding	Dpyd	IDA		Rat	PMID:7451435|RGD:11251748
Molecular Function	GO:0042802	identical protein binding	Dpyd	IPI	RGD:621218	Rat	PMID:7451435|RGD:11251748
Molecular Function	GO:0005506	iron ion binding	Dpyd	IDA		Rat	PMID:7451435|RGD:11251748
Molecular Function	GO:0050661	NADP binding	Dpyd	IDA		Rat	PMID:7626590|RGD:1624989
Molecular Function	GO:0050661	NADP binding	Dpyd	IDA		Rat	PMID:8373446|RGD:8553278
Molecular Function	GO:0005515	protein binding	DPYD	IPI	UniProtKB:Q9BS40	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DPYD	IPI	UniProtKB:Q9HD26	Human	PMID:25416956
Molecular Function	GO:0042803	protein homodimerization activity	DPYD	IDA		Human	PMID:1512248
Molecular Function	GO:0042803	protein homodimerization activity	Dpyd	IDA		Rat	PMID:8373446|RGD:8553278
Molecular Function	GO:0002058	uracil binding	Dpyd	IDA		Rat	PMID:7626590|RGD:1624989
Cellular Component	GO:0005737	cytoplasm	DPYD	IDA		Human	PMID:1512248
Cellular Component	GO:0005829	cytosol	DPYD	IDA		Human	PMID:9348115
Cellular Component	GO:0005829	cytosol	Dpyd	IDA		Mouse	PMID:5472365
Cellular Component	GO:0005829	cytosol	Dpyd	IDA		Mouse	PMID:12651209
Cellular Component	GO:0005829	cytosol	Dpyd	IDA		Rat	PMID:9348115|RGD:1599790
Biological Process	GO:0007568	aging	Dpyd	IEP		Rat	PMID:1544906|RGD:11251743
Biological Process	GO:0007623	circadian rhythm	Dpyd	IEP		Rat	PMID:19628084|RGD:5133425
Biological Process	GO:0007623	circadian rhythm	Dpyd	IDA		Rat	PMID:3202908|RGD:11251745
Biological Process	GO:0007623	circadian rhythm	Dpyd	IDA		Rat	PMID:8504424|RGD:1599793
Biological Process	GO:0006248	CMP catabolic process	Dpyd	IDA		Mouse	PMID:5472365
Biological Process	GO:0006249	dCMP catabolic process	Dpyd	IDA		Mouse	PMID:5472365
Biological Process	GO:0046079	dUMP catabolic process	Dpyd	IDA		Mouse	PMID:5472365
Biological Process	GO:0006145	purine nucleobase catabolic process	DPYD	IMP		Human	PMID:11988088
Biological Process	GO:0006208	pyrimidine nucleobase catabolic process	DPYD	IMP		Human	PMID:11988088
Biological Process	GO:0006208	pyrimidine nucleobase catabolic process	Dpyd	IDA		Mouse	PMID:12651209
Biological Process	GO:0006208	pyrimidine nucleobase catabolic process	Dpyd	IDA		Rat	PMID:1629785|RGD:1599794
Biological Process	GO:0051384	response to glucocorticoid	Dpyd	IEP		Rat	PMID:9819714|RGD:632636
Biological Process	GO:0007584	response to nutrient	Dpyd	IDA		Rat	PMID:8252488|RGD:1599792
Biological Process	GO:0014070	response to organic cyclic compound	Dpyd	IDA		Rat	PMID:9893640|RGD:11251752
Biological Process	GO:0009410	response to xenobiotic stimulus	Dpyd	IDA		Rat	PMID:8161345|RGD:1599791
Biological Process	GO:0006214	thymidine catabolic process	DPYD	IDA		Human	PMID:1512248
Biological Process	GO:0006210	thymine catabolic process	DPYD	IDA		Human	PMID:10410956
Biological Process	GO:0046050	UMP catabolic process	Dpyd	IDA		Mouse	PMID:5472365
Biological Process	GO:0006212	uracil catabolic process	DPYD	IDA		Human	PMID:1512248
Biological Process	GO:0006212	uracil catabolic process	DPYD	IDA		Human	PMID:18075467
Biological Process	GO:0019860	uracil metabolic process	Dpyd	IDA		Rat	PMID:7626590|RGD:1624989

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern