Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DRD3
  • Mouse genes Drd3
  • Rat genes Drd3
  • Zfish genes drd3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Drd3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031748	D1 dopamine receptor binding	Drd3	IPI	RGD:2518	Rat	PMID:14732731|RGD:7248458
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	DRD3	IDA		Human	PMID:8301582
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	Drd3	IDA		Mouse	PMID:8700864
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	Drd3	IDA		Mouse	PMID:7566118
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	Drd3	IDA		Mouse	PMID:8836575
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	Drd3	IDA		Rat	PMID:1975644|RGD:728430
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	Drd3	IDA		Rat	PMID:8302280|RGD:8554810
Molecular Function	GO:0005515	protein binding	DRD3	IPI	UniProtKB:P21333	Human	PMID:10692483
Molecular Function	GO:0005515	protein binding	DRD3	IPI	UniProtKB:O75781	Human	PMID:16386234
Molecular Function	GO:0005515	protein binding	DRD3	IPI	UniProtKB:P18901	Human	PMID:18424554
Molecular Function	GO:0005515	protein binding	DRD3	IPI	UniProtKB:P21333	Human	PMID:26460884
Molecular Function	GO:0005515	protein binding	Drd3	IPI	PR:Q9Z0P4	Mouse	PMID:16386234
Molecular Function	GO:0005515	protein binding	Drd3	IPI	RGD:727938	Rat	PMID:14499480|RGD:1302428
Molecular Function	GO:0005515	protein binding	Drd3	IPI	RGD:2070	Rat	PMID:16902178|RGD:1581469
Molecular Function	GO:0005515	protein binding	Drd3	IPI	UniProtKB:P18901	Rat	PMID:18424554|RGD:8554146
Molecular Function	GO:0005515	protein binding	Drd3	IPI	RGD:621859	Rat	PMID:19465068|RGD:2311555
Molecular Function	GO:0019904	protein domain specific binding	Drd3	IPI	RGD:68338	Rat	PMID:14617818|RGD:1581465
Cellular Component	GO:0045177	apical part of cell	Drd3	IDA		Rat	PMID:9822449|RGD:1625082
Cellular Component	GO:0042995	cell projection	Drd3	IDA		Rat	PMID:15584906|RGD:1581464
Cellular Component	GO:0098691	dopaminergic synapse	Drd3	IDA		Mouse	PMID:27393374
Cellular Component	GO:0098691	dopaminergic synapse	Drd3	EXP		Mouse	PMID:27393374
Cellular Component	GO:0030139	endocytic vesicle	Drd3	IDA		Rat	PMID:14617818|RGD:1581465
Cellular Component	GO:0098982	GABA-ergic synapse	Drd3	EXP		Rat	PMID:16510729|RGD:13702467
Cellular Component	GO:0098982	GABA-ergic synapse	Drd3	IDA		Rat	PMID:16510729|RGD:13702467
Cellular Component	GO:0098978	glutamatergic synapse	Drd3	IDA		Rat	PMID:23001156|RGD:13702187
Cellular Component	GO:0016020	membrane	Drd3	IDA		Mouse	PMID:9651217
Cellular Component	GO:0016020	membrane	Drd3	IDA		Rat	PMID:8302280|RGD:8554810
Cellular Component	GO:0005886	plasma membrane	DRD3	IDA		Human	PMID:16386234
Cellular Component	GO:0005886	plasma membrane	DRD3	IDA		Human	PMID:18424554
Cellular Component	GO:0005886	plasma membrane	DRD3	IDA		Human	PMID:20531939
Cellular Component	GO:0005886	plasma membrane	DRD3	IDA		Human	PMID:8413587
Cellular Component	GO:0005886	plasma membrane	Drd3	IDA		Mouse	PMID:16386234
Cellular Component	GO:0005886	plasma membrane	Drd3	IDA		Mouse	PMID:9651217
Cellular Component	GO:0005886	plasma membrane	Drd3	IDA		Rat	PMID:14499480|RGD:1302428
Cellular Component	GO:0098839	postsynaptic density membrane	Drd3	IDA		Rat	PMID:23001156|RGD:13702187
Biological Process	GO:0046717	acid secretion	Drd3	IDA		Rat	PMID:8302280|RGD:8554810
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	DRD3	IDA		Human	PMID:18424554
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	Drd3	IDA		Mouse	PMID:16386234
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	DRD3	IDA		Human	PMID:18424554
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	DRD3	IDA		Human	PMID:7907363
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	DRD3	IDA		Human	PMID:8666994
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	Drd3	IDA		Rat	PMID:8302280|RGD:8554810
Biological Process	GO:0050482	arachidonic acid secretion	DRD3	IDA		Human	PMID:8301582
Biological Process	GO:0006914	autophagy	Drd3	IMP		Rat	PMID:26649942|RGD:13506953
Biological Process	GO:0048148	behavioral response to cocaine	DRD3	IEP		Human	PMID:8815892
Biological Process	GO:0048148	behavioral response to cocaine	Drd3	IMP		Mouse	MGI:MGI:4418640|PMID:10432116
Biological Process	GO:0048148	behavioral response to cocaine	Drd3	IMP		Rat	PMID:16026479|RGD:7175068
Biological Process	GO:0032922	circadian regulation of gene expression	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:15878801
Biological Process	GO:0007212	dopamine receptor signaling pathway	Drd3	IGI	MGI:MGI:99578	Mouse	PMID:12097513
Biological Process	GO:0007212	dopamine receptor signaling pathway	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:15016423
Biological Process	GO:0007212	dopamine receptor signaling pathway	Drd3	IGI	MGI:MGI:94924	Mouse	PMID:12097513
Biological Process	GO:0002031	G protein-coupled receptor internalization	DRD3	IDA		Human	PMID:18424554
Biological Process	GO:0002031	G protein-coupled receptor internalization	Drd3	IDA		Rat	PMID:14617818|RGD:1581465
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	DRD3	IDA		Human	PMID:7911712
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Drd3	IMP		Rat	PMID:15265811|RGD:1625070
Biological Process	GO:0035483	gastric emptying	Drd3	IMP		Rat	PMID:18600456|RGD:6907451
Biological Process	GO:0006874	intracellular calcium ion homeostasis	DRD3	IDA		Human	PMID:7911712
Biological Process	GO:0007626	locomotory behavior	Drd3	IGI	MGI:MGI:99578	Mouse	PMID:9354330
Biological Process	GO:0007626	locomotory behavior	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:8700864
Biological Process	GO:0007626	locomotory behavior	Drd3	IGI	MGI:MGI:99578	Mouse	PMID:10884517
Biological Process	GO:0007626	locomotory behavior	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:9402626
Biological Process	GO:0007626	locomotory behavior	Drd3	IGI	MGI:MGI:94924	Mouse	PMID:9354330
Biological Process	GO:0007626	locomotory behavior	Drd3	IGI	MGI:MGI:97441	Mouse	PMID:12574430
Biological Process	GO:0050883	musculoskeletal movement, spinal reflex action	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:15601940
Biological Process	GO:0043066	negative regulation of apoptotic process	Drd3	IDA		Rat	PMID:25989500|RGD:13506961
Biological Process	GO:0045776	negative regulation of blood pressure	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:9691085
Biological Process	GO:0060160	negative regulation of dopamine receptor signaling pathway	Drd3	IGI	MGI:MGI:99578	Mouse	PMID:12097513
Biological Process	GO:0060160	negative regulation of dopamine receptor signaling pathway	Drd3	IGI	MGI:MGI:94924	Mouse	PMID:12097513
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	Drd3	IDA		Mouse	PMID:9651217
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Drd3	IMP	MGI:MGI:3698033	Mouse	PMID:17251429
Biological Process	GO:0050709	negative regulation of protein secretion	DRD3	IDA		Human	PMID:16839358
Biological Process	GO:0032416	negative regulation of sodium:proton antiporter activity	Drd3	IMP		Rat	PMID:15265811|RGD:1625070
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Drd3	IDA		Rat	PMID:16902178|RGD:1581469
Biological Process	GO:0048709	oligodendrocyte differentiation	Drd3	IDA		Mouse	PMID:9651217
Biological Process	GO:0008284	positive regulation of cell population proliferation	Drd3	IDA		Rat	PMID:15584906|RGD:1581464
Biological Process	GO:0032467	positive regulation of cytokinesis	DRD3	IMP		Human	PMID:22888021
Biological Process	GO:0060161	positive regulation of dopamine receptor signaling pathway	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:15016423
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Drd3	IMP		Rat	PMID:8302280|RGD:8554810
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Drd3	IDA		Rat	PMID:14621190|RGD:1581467
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Drd3	IDA		Rat	PMID:16902178|RGD:1581469
Biological Process	GO:0060134	prepulse inhibition	DRD3	IMP		Human	PMID:18325483
Biological Process	GO:0043491	protein kinase B signaling	Drd3	IMP	MGI:MGI:3698033	Mouse	PMID:17251429
Biological Process	GO:0002016	regulation of blood volume by renin-angiotensin	Drd3	IGI	MGI:MGI:87964	Mouse	PMID:9691085
Biological Process	GO:0002016	regulation of blood volume by renin-angiotensin	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:9691085
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	Drd3	IMP		Rat	PMID:15913875|RGD:1625069
Biological Process	GO:0014059	regulation of dopamine secretion	Drd3	IMP	MGI:MGI:3044114	Mouse	PMID:9482807
Biological Process	GO:0014059	regulation of dopamine secretion	Drd3	IMP	MGI:MGI:3698033	Mouse	PMID:12044470
Biological Process	GO:0014059	regulation of dopamine secretion	Drd3	IMP		Rat	PMID:16490190|RGD:1625068
Biological Process	GO:0019216	regulation of lipid metabolic process	Drd3	IMP	MGI:MGI:3044114	Mouse	PMID:15084447
Biological Process	GO:0040012	regulation of locomotion	Drd3	IMP		Rat	PMID:15913875|RGD:1625069
Biological Process	GO:0090325	regulation of locomotion involved in locomotory behavior	Drd3	IMP		Rat	PMID:22394078|RGD:6907452
Biological Process	GO:0040014	regulation of multicellular organism growth	Drd3	IMP	MGI:MGI:3044114	Mouse	PMID:15084447
Biological Process	GO:0051580	regulation of neurotransmitter uptake	Drd3	IDA		Mouse	PMID:27393374
Biological Process	GO:0051580	regulation of neurotransmitter uptake	Drd3	EXP		Mouse	PMID:27393374
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Drd3	EXP		Rat	PMID:16510729|RGD:13702467
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Drd3	IDA		Rat	PMID:16510729|RGD:13702467
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Drd3	IEP		Rat	PMID:16510729|RGD:13702467
Biological Process	GO:0001975	response to amphetamine	Drd3	IGI	MGI:MGI:99578	Mouse	PMID:12097513
Biological Process	GO:0001975	response to amphetamine	Drd3	IGI	MGI:MGI:94924	Mouse	PMID:12097513
Biological Process	GO:0042220	response to cocaine	DRD3	IEP		Human	PMID:10415668
Biological Process	GO:0042220	response to cocaine	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:10943692
Biological Process	GO:0045471	response to ethanol	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:11988344
Biological Process	GO:0034776	response to histamine	DRD3	IDA		Human	PMID:16839358
Biological Process	GO:0043278	response to morphine	Drd3	IMP	MGI:MGI:1857159	Mouse	PMID:12574430
Biological Process	GO:0009410	response to xenobiotic stimulus	Drd3	IDA		Rat	PMID:1975644|RGD:728430
Biological Process	GO:0008542	visual learning	Drd3	IMP	MGI:MGI:2388387	Mouse	PMID:12097513

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern