Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Drd4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DRD4
- Mouse genes Drd4
- Rat genes Drd4
- Zfish genes drd4-rs,drd4a,drd4b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Drd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035240	dopamine binding	DRD4	IDA		Human	PMID:1319557
Molecular Function	GO:0035240	dopamine binding	DRD4	IDA		Human	PMID:9003072
Molecular Function	GO:0035240	dopamine binding	Drd4	IDA		Rat	PMID:15448188\|RGD:1600953
Molecular Function	GO:0035240	dopamine binding	Drd4	IPI	CHEBI:18243	Rat	PMID:8078498\|RGD:7248459
Molecular Function	GO:0004952	dopamine neurotransmitter receptor activity	DRD4	IDA		Human	PMID:8413587
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	DRD4	IDA		Human	PMID:1840645
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	DRD4	IMP		Human	PMID:27659709
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	DRD4	IDA		Human	PMID:9003072
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	Drd4	IMP	MGI:MGI:2178631	Mouse	PMID:11356863
Molecular Function	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	Drd4	IDA		Rat	PMID:12711714\|RGD:1358607
Molecular Function	GO:0051379	epinephrine binding	DRD4	IDA		Human	PMID:9003072
Molecular Function	GO:1901363	heterocyclic compound binding	Drd4	IDA		Rat	PMID:17314300\|RGD:1625010
Molecular Function	GO:1901363	heterocyclic compound binding	Drd4	IPI	CHEBI:75401	Rat	PMID:17314300\|RGD:1625010
Molecular Function	GO:1901363	heterocyclic compound binding	Drd4	IDA		Rat	PMID:8078498\|RGD:7248459
Molecular Function	GO:1901363	heterocyclic compound binding	Drd4	IPI	CHEBI:9233\|CHEBI:5613\|CHEBI:3766\|CHEBI:73298\|CHEBI:75401	Rat	PMID:8078498\|RGD:7248459
Molecular Function	GO:0042802	identical protein binding	DRD4	IPI	UniProtKB:P21917	Human	PMID:21184734
Molecular Function	GO:0042802	identical protein binding	DRD4	IPI	UniProtKB:P21917	Human	PMID:21320289
Molecular Function	GO:0051380	norepinephrine binding	DRD4	IDA		Human	PMID:9003072
Molecular Function	GO:0005515	protein binding	DRD4	IPI	UniProtKB:P48544	Human	PMID:12297500
Molecular Function	GO:0005515	protein binding	DRD4	IPI	UniProtKB:P48549	Human	PMID:12297500
Molecular Function	GO:0005515	protein binding	DRD4	IPI	UniProtKB:Q92806	Human	PMID:12297500
Molecular Function	GO:0005515	protein binding	DRD4	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DRD4	IPI	UniProtKB:P17677	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DRD4	IPI	UniProtKB:P50579	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DRD4	IPI	UniProtKB:P61764	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DRD4	IPI	UniProtKB:Q96P71-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Drd4	IPI	RGD:727938	Rat	PMID:14499480\|RGD:1302428
Molecular Function	GO:0005515	protein binding	Drd4	IPI	RGD:621859	Rat	PMID:19465068\|RGD:2311555
Molecular Function	GO:0017124	SH3 domain binding	DRD4	IDA		Human	PMID:9843378
Cellular Component	GO:0030424	axon	Drd4	IDA		Rat	PMID:10819901\|RGD:1625058
Cellular Component	GO:0043679	axon terminus	Drd4	IDA		Rat	PMID:14519509\|RGD:7248766
Cellular Component	GO:0005938	cell cortex	Drd4	IDA		Rat	PMID:10898094\|RGD:1625055
Cellular Component	GO:0005813	centrosome	DRD4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	Drd4	IDA		Rat	PMID:10898094\|RGD:1625055
Cellular Component	GO:0030425	dendrite	Drd4	IDA		Rat	PMID:10819901\|RGD:1625058
Cellular Component	GO:0030425	dendrite	Drd4	IDA		Rat	PMID:10898094\|RGD:1625055
Cellular Component	GO:0043197	dendritic spine	Drd4	IDA		Rat	PMID:10819901\|RGD:1625058
Cellular Component	GO:0098982	GABA-ergic synapse	Drd4	EXP		Rat	PMID:24155292\|RGD:13702381
Cellular Component	GO:0098982	GABA-ergic synapse	Drd4	IDA		Rat	PMID:24155292\|RGD:13702381
Cellular Component	GO:0098978	glutamatergic synapse	Drd4	IDA		Mouse	PMID:18832154
Cellular Component	GO:0098978	glutamatergic synapse	Drd4	EXP		Mouse	PMID:18832154
Cellular Component	GO:0098978	glutamatergic synapse	Drd4	IMP		Mouse	PMID:18832154
Cellular Component	GO:0098978	glutamatergic synapse	Drd4	EXP		Rat	PMID:14586014\|RGD:13702153
Cellular Component	GO:0098978	glutamatergic synapse	Drd4	IDA		Rat	PMID:14586014\|RGD:13702153
Cellular Component	GO:0098978	glutamatergic synapse	Drd4	EXP		Rat	PMID:24155292\|RGD:13702381
Cellular Component	GO:0098978	glutamatergic synapse	Drd4	IDA		Rat	PMID:24155292\|RGD:13702381
Cellular Component	GO:0016020	membrane	DRD4	IDA		Human	PMID:7512953
Cellular Component	GO:0043025	neuronal cell body	Drd4	IDA		Rat	PMID:10898094\|RGD:1625055
Cellular Component	GO:0005886	plasma membrane	DRD4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	DRD4	IDA		Human	PMID:15755724
Cellular Component	GO:0005886	plasma membrane	DRD4	IDA		Human	PMID:20531939
Cellular Component	GO:0005886	plasma membrane	DRD4	IDA		Human	PMID:27659709
Cellular Component	GO:0005886	plasma membrane	DRD4	IDA		Human	PMID:8413587
Cellular Component	GO:0005886	plasma membrane	DRD4	IDA		Human	PMID:9003072
Cellular Component	GO:0005886	plasma membrane	DRD4	IDA		Human	PMID:9843378
Cellular Component	GO:0005886	plasma membrane	Drd4	IDA		Rat	PMID:10819901\|RGD:1625058
Cellular Component	GO:0045211	postsynaptic membrane	Drd4	IDA		Rat	PMID:14519509\|RGD:7248766
Cellular Component	GO:0042734	presynaptic membrane	Drd4	IDA		Rat	PMID:14519509\|RGD:7248766
Cellular Component	GO:0043195	terminal bouton	Drd4	IDA		Rat	PMID:10819901\|RGD:1625058
Cellular Component	GO:0012506	vesicle membrane	Drd4	IDA		Rat	PMID:10819901\|RGD:1625058
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	DRD4	IMP		Human	PMID:27659709
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	DRD4	IDA		Human	PMID:7512953
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	DRD4	IDA		Human	PMID:9003072
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	DRD4	IDA		Human	PMID:9843378
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	Drd4	IMP	MGI:MGI:3576789	Mouse	PMID:14684868
Biological Process	GO:0008344	adult locomotory behavior	Drd4	IMP	MGI:MGI:2178631	Mouse	PMID:9323127
Biological Process	GO:0050482	arachidonic acid secretion	DRD4	IDA		Human	PMID:7512953
Biological Process	GO:0008306	associative learning	Drd4	IMP		Rat	PMID:15987936\|RGD:1600969
Biological Process	GO:0001662	behavioral fear response	Drd4	IMP		Rat	PMID:16708027\|RGD:1600974
Biological Process	GO:0048148	behavioral response to cocaine	Drd4	IMP	MGI:MGI:2178631	Mouse	PMID:12783155
Biological Process	GO:0048148	behavioral response to cocaine	Drd4	IMP	MGI:MGI:2178631	Mouse	PMID:9323127
Biological Process	GO:0007623	circadian rhythm	Drd4	IEP		Rat	PMID:18778704\|RGD:7175073
Biological Process	GO:0007212	dopamine receptor signaling pathway	DRD4	IDA		Human	PMID:1840645
Biological Process	GO:0007212	dopamine receptor signaling pathway	Drd4	IDA		Rat	PMID:12711714\|RGD:1358607
Biological Process	GO:0042596	fear response	Drd4	IMP	MGI:MGI:2178631	Mouse	PMID:11860516
Biological Process	GO:0060080	inhibitory postsynaptic potential	Drd4	IMP	MGI:MGI:3576789	Mouse	PMID:14684868
Biological Process	GO:0060080	inhibitory postsynaptic potential	Drd4	IMP	MGI:MGI:2178631	Mouse	PMID:11356863
Biological Process	GO:0050709	negative regulation of protein secretion	DRD4	IDA		Human	PMID:16839358
Biological Process	GO:0050805	negative regulation of synaptic transmission	Drd4	IDA		Rat	PMID:17314300\|RGD:1625010
Biological Process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	Drd4	IDA		Rat	PMID:24888351\|RGD:13506962
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	Drd4	IDA		Rat	PMID:24888351\|RGD:13506962
Biological Process	GO:1901386	negative regulation of voltage-gated calcium channel activity	DRD4	IDA		Human	PMID:7921596
Biological Process	GO:0008355	olfactory learning	Drd4	IMP		Rat	PMID:15987936\|RGD:1600969
Biological Process	GO:0009648	photoperiodism	Drd4	IEP		Rat	PMID:18321474\|RGD:2301031
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Drd4	IMP		Rat	PMID:21622557\|RGD:7248611
Biological Process	GO:0033674	positive regulation of kinase activity	DRD4	IDA		Human	PMID:15755724
Biological Process	GO:0043406	positive regulation of MAP kinase activity	DRD4	IDA		Human	PMID:9843378
Biological Process	GO:0043406	positive regulation of MAP kinase activity	DRD4	IDA		Human	PMID:15755724
Biological Process	GO:0060406	positive regulation of penile erection	Drd4	IDA		Rat	PMID:15814200\|RGD:7175074
Biological Process	GO:0032417	positive regulation of sodium:proton antiporter activity	DRD4	IDA		Human	PMID:7512953
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Drd4	EXP		Rat	PMID:24155292\|RGD:13702381
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Drd4	IDA		Rat	PMID:24155292\|RGD:13702381
Biological Process	GO:0050848	regulation of calcium-mediated signaling	Drd4	IMP		Rat	PMID:16365279\|RGD:1600972
Biological Process	GO:0042752	regulation of circadian rhythm	Drd4	IMP		Mouse	MGI:MGI:5518489\|PMID:24048828
Biological Process	GO:0042053	regulation of dopamine metabolic process	Drd4	IMP	MGI:MGI:2178631	Mouse	PMID:9323127
Biological Process	GO:0046928	regulation of neurotransmitter secretion	Drd4	IMP		Rat	PMID:15363981\|RGD:1625053
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Drd4	EXP		Rat	PMID:14586014\|RGD:13702153
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Drd4	IDA		Rat	PMID:14586014\|RGD:13702153
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Drd4	IEP		Rat	PMID:14586014\|RGD:13702153
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Drd4	IDA		Mouse	PMID:18832154
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Drd4	IMP		Mouse	PMID:18832154
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Drd4	EXP		Mouse	PMID:18832154
Biological Process	GO:0001975	response to amphetamine	Drd4	IMP	MGI:MGI:2178631	Mouse	PMID:9323127
Biological Process	GO:0034776	response to histamine	DRD4	IDA		Human	PMID:16839358
Biological Process	GO:0048545	response to steroid hormone	Drd4	IEP		Rat	PMID:18809391\|RGD:7248683
Biological Process	GO:0060041	retina development in camera-type eye	Drd4	IEP		Rat	PMID:18778704\|RGD:7175073
Biological Process	GO:0007614	short-term memory	Drd4	IMP		Rat	PMID:15138447\|RGD:1625054
Biological Process	GO:0021520	spinal cord motor neuron cell fate specification	drd4a	IMP	ZFIN:ZDB-MRPHLNO-131121-2	Zfish	PMID:23707737
Biological Process	GO:0001963	synaptic transmission, dopaminergic	Drd4	IMP		Rat	PMID:15476261\|RGD:1600954
Biological Process	GO:0021514	ventral spinal cord interneuron differentiation	drd4a	IMP	ZFIN:ZDB-MRPHLNO-131121-2	Zfish	PMID:23707737

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.