Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DRD5
  • Mouse genes Drd5
  • Rat genes Drd5
  • Zfish genes drd5a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Drd5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035240	dopamine binding	DRD5	IDA		Human	PMID:1826762
Molecular Function	GO:0004952	dopamine neurotransmitter receptor activity	DRD5	IDA		Human	PMID:1826762
Molecular Function	GO:0004952	dopamine neurotransmitter receptor activity	Drd5	IDA		Rat	PMID:1831904|RGD:728422
Molecular Function	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	Drd5	IDA		Mouse	PMID:16962565
Molecular Function	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs	Drd5	IMP		Mouse	PMID:13679419
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Drd5	IPI	RGD:1310221	Rat	PMID:12623966|RGD:730287
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Drd5	IPI	RGD:71018	Rat	PMID:12623966|RGD:730287
Molecular Function	GO:0005515	protein binding	DRD5	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Drd5	IPI	RGD:621859	Rat	PMID:19465068|RGD:2311555
Cellular Component	GO:0030424	axon	Drd5	IDA		Rat	PMID:16175554|RGD:5686427
Cellular Component	GO:0031526	brush border membrane	Drd5	IDA		Mouse	PMID:15598876
Cellular Component	GO:0031526	brush border membrane	Drd5	IDA		Rat	PMID:12623966|RGD:730287
Cellular Component	GO:0060170	ciliary membrane	DRD5	IDA		Human	PMID:20531939
Cellular Component	GO:0005929	cilium	DRD5	IDA		Human	PMID:28154160
Cellular Component	GO:0030425	dendrite	Drd5	IDA		Rat	PMID:16175554|RGD:5686427
Cellular Component	GO:0043197	dendritic spine	Drd5	IDA		Rat	PMID:21749912|RGD:5686425
Cellular Component	GO:0098978	glutamatergic synapse	Drd5	EXP		Rat	PMID:16914681|RGD:13702230
Cellular Component	GO:0098978	glutamatergic synapse	Drd5	IDA		Rat	PMID:16914681|RGD:13702230
Cellular Component	GO:0098978	glutamatergic synapse	Drd5	IDA		Rat	PMID:21749912|RGD:5686425
Cellular Component	GO:0043025	neuronal cell body	Drd5	IDA		Rat	PMID:21749912|RGD:5686425
Cellular Component	GO:0097730	non-motile cilium	DRD5	IDA		Human	PMID:20531939
Cellular Component	GO:0005886	plasma membrane	DRD5	IDA		Human	PMID:10531415
Cellular Component	GO:0005886	plasma membrane	DRD5	IDA		Human	PMID:11500503
Cellular Component	GO:0098839	postsynaptic density membrane	Drd5	IDA		Rat	PMID:21749912|RGD:5686425
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	DRD5	IDA		Human	PMID:1826762
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	DRD5	IDA		Human	PMID:18403039
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	Drd5	IMP		Rat	PMID:12688394|RGD:1581394
Biological Process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	Drd5	IMP		Rat	PMID:15328036|RGD:1600979
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	DRD5	IDA		Human	PMID:11500503
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Drd5	IDA		Mouse	PMID:15598876
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Drd5	IDA		Rat	PMID:1831904|RGD:728422
Biological Process	GO:0008306	associative learning	Drd5	IMP	MGI:MGI:3528074	Mouse	PMID:15696326
Biological Process	GO:0071870	cellular response to catecholamine stimulus	DRD5	IDA		Human	PMID:18403039
Biological Process	GO:0007212	dopamine receptor signaling pathway	Drd5	IDA		Rat	PMID:1831904|RGD:728422
Biological Process	GO:0060292	long-term synaptic depression	Drd5	IMP		Mouse	PMID:13679419
Biological Process	GO:0007617	mating behavior	Drd5	IMP	MGI:MGI:3528074	Mouse	PMID:15696326
Biological Process	GO:0045776	negative regulation of blood pressure	Drd5	IGI	MGI:MGI:109147	Mouse	PMID:12486173
Biological Process	GO:0045776	negative regulation of blood pressure	Drd5	IMP	MGI:MGI:3528074	Mouse	PMID:15598876
Biological Process	GO:0045776	negative regulation of blood pressure	Drd5	IMP	MGI:MGI:3528074	Mouse	PMID:12486173
Biological Process	GO:0030336	negative regulation of cell migration	Drd5	IMP		Rat	PMID:12688394|RGD:1581394
Biological Process	GO:0033861	negative regulation of NAD(P)H oxidase activity	DRD5	IDA		Human	PMID:16352863
Biological Process	GO:0006469	negative regulation of protein kinase activity	Drd5	IMP		Rat	PMID:12688394|RGD:1581394
Biological Process	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	Drd5	IMP	MGI:MGI:3528074	Mouse	PMID:12486173
Biological Process	GO:0072593	reactive oxygen species metabolic process	DRD5	IDA		Human	PMID:16352863
Biological Process	GO:0045924	regulation of female receptivity	Drd5	IMP	MGI:MGI:3528074	Mouse	PMID:15696326
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Drd5	EXP		Rat	PMID:16914681|RGD:13702230
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Drd5	IDA		Rat	PMID:16914681|RGD:13702230
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Drd5	IEP		Rat	PMID:16914681|RGD:13702230
Biological Process	GO:0001992	regulation of systemic arterial blood pressure by vasopressin	Drd5	IGI	MGI:MGI:1859216	Mouse	PMID:12486173
Biological Process	GO:0001992	regulation of systemic arterial blood pressure by vasopressin	Drd5	IGI	MGI:MGI:1347010	Mouse	PMID:12486173
Biological Process	GO:0001975	response to amphetamine	Drd5	IGI	MGI:MGI:99578	Mouse	PMID:11823893
Biological Process	GO:0042220	response to cocaine	Drd5	IMP	MGI:MGI:3528074	Mouse	PMID:12768268
Biological Process	GO:0046960	sensitization	Drd5	IGI	MGI:MGI:99578	Mouse	PMID:11823893
Biological Process	GO:0019226	transmission of nerve impulse	Drd5	IMP	MGI:MGI:2675755	Mouse	PMID:12867509
Biological Process	GO:0008542	visual learning	Drd5	IMP		Rat	PMID:17142305|RGD:1600982
Biological Process	GO:0042060	wound healing	Drd5	IMP	MGI:MGI:3528074	Mouse	PMID:11595429

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern