Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DROSHA
  • Mouse genes Drosha
  • Rat genes Drosha
  • Zfish genes drosha
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Drosha

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0017151	DEAD/H-box RNA helicase binding	DROSHA	IPI	UniProtKB:P17844	Human	PMID:18548003
Molecular Function	GO:0001530	lipopolysaccharide binding	DROSHA	IDA		Human	PMID:20180804
Molecular Function	GO:0070878	primary miRNA binding	DROSHA	IDA		Human	PMID:31507089
Molecular Function	GO:0070878	primary miRNA binding	Drosha	IDA		Mouse	PMID:28819115
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:Q8WYQ5	Human	PMID:15574589
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:P17844	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:Q15797	Human	PMID:18548003
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:P04637	Human	PMID:19626115
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:P17844	Human	PMID:19626115
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:Q8WYQ5	Human	PMID:19626115
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:P17844	Human	PMID:22222205
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:Q8WYQ5	Human	PMID:22222205
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:Q8WYQ5	Human	PMID:22796965
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:P35637	Human	PMID:23232809
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:Q8WYQ5	Human	PMID:23995758
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:P04637	Human	PMID:24219989
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:Q8WYQ5	Human	PMID:24581491
Molecular Function	GO:0005515	protein binding	DROSHA	IPI	UniProtKB:Q8WYQ5	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	Drosha	IPI	UniProtKB:Q99MR6	Mouse	MGI:MGI:4359572|PMID:19632182
Molecular Function	GO:0005515	protein binding	drosha	IPI	ZFIN:ZDB-GENE-030131-3421	Zfish	PMID:31029426
Molecular Function	GO:0042803	protein homodimerization activity	DROSHA	IDA		Human	PMID:15574589
Molecular Function	GO:0070412	R-SMAD binding	DROSHA	IPI	UniProtKB:Q15797	Human	PMID:18548003
Molecular Function	GO:0070412	R-SMAD binding	DROSHA	IPI	UniProtKB:Q99717	Human	PMID:18548003
Molecular Function	GO:0004525	ribonuclease III activity	DROSHA	IDA		Human	PMID:14508493
Molecular Function	GO:0004525	ribonuclease III activity	DROSHA	IDA		Human	PMID:15574589
Molecular Function	GO:0003723	RNA binding	DROSHA	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	DROSHA	HDA		Human	PMID:22681889
Molecular Function	GO:0004521	RNA endonuclease activity	Drosha	IDA		Mouse	PMID:20424607
Molecular Function	GO:0046332	SMAD binding	DROSHA	IPI	UniProtKB:P84022	Human	PMID:18548003
Cellular Component	GO:0005829	cytosol	DROSHA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098978	glutamatergic synapse	Drosha	IEP		Mouse	PMID:22897173
Cellular Component	GO:0098978	glutamatergic synapse	Drosha	IPI		Mouse	PMID:22897173
Cellular Component	GO:0098978	glutamatergic synapse	Drosha	IDA		Mouse	PMID:22897173
Cellular Component	GO:0070877	microprocessor complex	DROSHA	IDA		Human	PMID:15574589
Cellular Component	GO:0005654	nucleoplasm	DROSHA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0014069	postsynaptic density	Drosha	IDA		Mouse	PMID:22897173
Cellular Component	GO:0014069	postsynaptic density	Drosha	IEP		Mouse	PMID:22897173
Cellular Component	GO:0014069	postsynaptic density	Drosha	IPI		Mouse	PMID:22897173
Biological Process	GO:0001525	angiogenesis	drosha	IMP	ZFIN:ZDB-MRPHLNO-180601-2	Zfish	PMID:29339534
Biological Process	GO:0001525	angiogenesis	drosha	IMP	ZFIN:ZDB-MRPHLNO-180601-1	Zfish	PMID:29339534
Biological Process	GO:0001525	angiogenesis	drosha	IMP	ZFIN:ZDB-MRPHLNO-180601-1,ZFIN:ZDB-MRPHLNO-180601-2	Zfish	PMID:29339534
Biological Process	GO:0048514	blood vessel morphogenesis	drosha	IMP	ZFIN:ZDB-MRPHLNO-180601-1,ZFIN:ZDB-MRPHLNO-180601-2	Zfish	PMID:29339534
Biological Process	GO:0048514	blood vessel morphogenesis	drosha	IMP	ZFIN:ZDB-MRPHLNO-180601-1	Zfish	PMID:29339534
Biological Process	GO:0048514	blood vessel morphogenesis	drosha	IMP	ZFIN:ZDB-MRPHLNO-180601-2	Zfish	PMID:29339534
Biological Process	GO:0050829	defense response to Gram-negative bacterium	DROSHA	IDA		Human	PMID:20180804
Biological Process	GO:0050830	defense response to Gram-positive bacterium	DROSHA	IDA		Human	PMID:20180804
Biological Process	GO:0010586	miRNA metabolic process	Drosha	IMP		Mouse	PMID:20424607
Biological Process	GO:0010628	positive regulation of gene expression	Drosha	IMP		Mouse	MGI:MGI:5494393|PMID:22053081
Biological Process	GO:0031054	pre-miRNA processing	Drosha	IDA		Mouse	PMID:18604195
Biological Process	GO:0031053	primary miRNA processing	DROSHA	IDA		Human	PMID:14508493
Biological Process	GO:0031053	primary miRNA processing	DROSHA	IMP		Human	PMID:14508493
Biological Process	GO:0031053	primary miRNA processing	DROSHA	IDA		Human	PMID:15574589
Biological Process	GO:0031053	primary miRNA processing	drosha	IGI	ZFIN:ZDB-GENE-030131-3421	Zfish	PMID:31029426
Biological Process	GO:0010468	regulation of gene expression	Drosha	IMP		Mouse	PMID:22000014
Biological Process	GO:0050727	regulation of inflammatory response	Drosha	IMP		Mouse	PMID:18725527
Biological Process	GO:2000628	regulation of miRNA metabolic process	Drosha	IMP		Mouse	PMID:22053081
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	Drosha	IMP		Mouse	PMID:18725527

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern