Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DSPP
  • Mouse genes Dspp
  • Rat genes Dspp
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dspp

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	Dspp	IDA		Rat	PMID:22615197|RGD:12914146
Molecular Function	GO:0005515	protein binding	Dspp	IPI	UniProtKB:Q07936	Mouse	PMID:23525114
Molecular Function	GO:0005515	protein binding	Dspp	IPI	UniProtKB:P48037	Mouse	PMID:23525114
Molecular Function	GO:0005515	protein binding	Dspp	IPI	RGD:621170	Rat	PMID:23525114|RGD:12911212
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Dspp	IDA		Rat	PMID:16776771|RGD:1599799
Cellular Component	GO:0005737	cytoplasm	DSPP	IDA		Human	PMID:11856645
Cellular Component	GO:0005737	cytoplasm	Dspp	IDA		Rat	PMID:24404577|RGD:12911018
Cellular Component	GO:0031012	extracellular matrix	Dspp	IDA		Mouse	PMID:19001636
Cellular Component	GO:0031012	extracellular matrix	Dspp	IDA		Mouse	PMID:22798071
Cellular Component	GO:0005615	extracellular space	Dspp	IDA		Mouse	PMID:25027178
Cellular Component	GO:0005634	nucleus	Dspp	IDA		Mouse	PMID:19001636
Cellular Component	GO:0005634	nucleus	Dspp	IDA		Rat	PMID:23525114|RGD:12911212
Cellular Component	GO:0005886	plasma membrane	Dspp	IDA		Rat	PMID:23525114|RGD:12911212
Biological Process	GO:0036305	ameloblast differentiation	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:25027178
Biological Process	GO:0097186	amelogenesis	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:25027178
Biological Process	GO:0031214	biomineral tissue development	Dspp	IEP		Rat	PMID:20425127|RGD:4110819
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:16937369
Biological Process	GO:0051216	cartilage development	Dspp	IEP		Rat	PMID:20679519|RGD:12914771
Biological Process	GO:0030154	cell differentiation	Dspp	IEP		Rat	PMID:15308669|RGD:1599801
Biological Process	GO:0071460	cellular response to cell-matrix adhesion	Dspp	IDA		Mouse	PMID:17286598
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Dspp	IEP		Rat	PMID:20666749|RGD:5132633
Biological Process	GO:0032870	cellular response to hormone stimulus	Dspp	IEP		Rat	PMID:22946647|RGD:12911214
Biological Process	GO:0061448	connective tissue development	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:25027178
Biological Process	GO:0097187	dentinogenesis	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:25027178
Biological Process	GO:0097187	dentinogenesis	Dspp	IEP		Rat	PMID:24502800|RGD:12911210
Biological Process	GO:0060350	endochondral bone morphogenesis	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:26972716
Biological Process	GO:1901148	gene expression involved in extracellular matrix organization	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:23900597
Biological Process	GO:0048820	hair follicle maturation	Dspp	IEP		Rat	PMID:21908176|RGD:12914765
Biological Process	GO:0060425	lung morphogenesis	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:16937369
Biological Process	GO:0061978	mandibular condyle articular cartilage development	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:23900597
Biological Process	GO:0061978	mandibular condyle articular cartilage development	Dspp	IEP		Rat	PMID:20097540|RGD:15039407
Biological Process	GO:0060231	mesenchymal to epithelial transition	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:16937369
Biological Process	GO:1903011	negative regulation of bone development	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:26972716
Biological Process	GO:1902731	negative regulation of chondrocyte proliferation	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:25027178
Biological Process	GO:0061914	negative regulation of growth plate cartilage chondrocyte proliferation	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:26972716
Biological Process	GO:2001054	negative regulation of mesenchymal cell apoptotic process	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:16937369
Biological Process	GO:0071895	odontoblast differentiation	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:25027178
Biological Process	GO:0071895	odontoblast differentiation	Dspp	IEP		Rat	PMID:15763925|RGD:12911014
Biological Process	GO:0042476	odontogenesis	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:25027178
Biological Process	GO:0042476	odontogenesis	Dspp	IEP		Rat	PMID:28595095|RGD:12911016
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Dspp	IEP		Rat	PMID:15533758|RGD:1599800
Biological Process	GO:0090280	positive regulation of calcium ion import	Dspp	IDA		Rat	PMID:23525114|RGD:12911212
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:23900597
Biological Process	GO:0070175	positive regulation of enamel mineralization	Dspp	IDA		Mouse	PMID:16014627
Biological Process	GO:1901329	regulation of odontoblast differentiation	Dspp	IDA		Rat	PMID:15308669|RGD:1599801
Biological Process	GO:0009743	response to carbohydrate	Dspp	IEP		Rat	PMID:20088703|RGD:12914777
Biological Process	GO:0001666	response to hypoxia	Dspp	IEP		Rat	PMID:24661255|RGD:12911017
Biological Process	GO:0009612	response to mechanical stimulus	Dspp	IEP		Rat	PMID:22342686|RGD:12914152
Biological Process	GO:0071559	response to transforming growth factor beta	Dspp	IEP		Rat	PMID:22012415|RGD:12914763
Biological Process	GO:0072050	S-shaped body morphogenesis	Dspp	IMP	MGI:MGI:2653208	Mouse	PMID:16937369

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern