Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DUOX2
  • Mouse genes Duox2
  • Rat genes Duox2
  • Zfish genes duox
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Duox2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	DUOX2	IDA		Human	PMID:15972824
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	DUOX2	IDA		Human	PMID:15972824
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	DUOX2	IMP		Human	PMID:21565790
Molecular Function	GO:0005515	protein binding	DUOX2	IPI	UniProtKB:Q1HG43-2	Human	PMID:19339556
Molecular Function	GO:0005515	protein binding	DUOX2	IPI	UniProtKB:Q1HG44	Human	PMID:19339556
Molecular Function	GO:0005515	protein binding	DUOX2	IPI	UniProtKB:Q1HG44	Human	PMID:25761904
Cellular Component	GO:0045177	apical part of cell	DUOX2	IDA		Human	PMID:25761904
Cellular Component	GO:0031252	cell leading edge	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:19339556
Cellular Component	GO:0009986	cell surface	DUOX2	IGI	UniProtKB:Q1HG43	Human	PMID:22814254
Cellular Component	GO:0009986	cell surface	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:22814254
Cellular Component	GO:0005829	cytosol	DUOX2	IDA		Human	PMID:19339556
Cellular Component	GO:0005783	endoplasmic reticulum	DUOX2	IDA		Human	PMID:19339556
Cellular Component	GO:0070062	extracellular exosome	DUOX2	HDA		Human	PMID:19199708
Cellular Component	GO:0005886	plasma membrane	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:16651268
Cellular Component	GO:0005886	plasma membrane	DUOX2	IDA		Human	PMID:19339556
Cellular Component	GO:0005886	plasma membrane	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:25761904
Biological Process	GO:0048855	adenohypophysis morphogenesis	Duox2	IMP	MGI:MGI:3712359	Mouse	PMID:17440044
Biological Process	GO:0030282	bone mineralization	Duox2	IMP	MGI:MGI:3712359	Mouse	PMID:17440044
Biological Process	GO:0019221	cytokine-mediated signaling pathway	DUOX2	IDA		Human	PMID:16111680
Biological Process	GO:0050832	defense response to fungus	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:24098114
Biological Process	GO:0009566	fertilization	Duox2	IMP	MGI:MGI:3712359	Mouse	PMID:17440044
Biological Process	GO:0042445	hormone metabolic process	Duox2	IMP	MGI:MGI:3712359	Mouse	PMID:17440044
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:16651268
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:19339556
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:22814254
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:25761904
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:19494811
Biological Process	GO:0048839	inner ear development	Duox2	IMP	MGI:MGI:3712359	Mouse	PMID:17440044
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:19494811
Biological Process	GO:0048246	macrophage chemotaxis	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:25488917
Biological Process	GO:0035264	multicellular organism growth	Duox2	IMP	MGI:MGI:3712359	Mouse	PMID:17440044
Biological Process	GO:0030593	neutrophil chemotaxis	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:24842759
Biological Process	GO:2000147	positive regulation of cell motility	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:19339556
Biological Process	GO:0090303	positive regulation of wound healing	DUOX2	IGI	UniProtKB:Q1HG44	Human	PMID:19339556
Biological Process	GO:0009617	response to bacterium	duox	IMP	ZFIN:ZDB-MRPHLNO-100902-1	Zfish	PMID:20709024
Biological Process	GO:0051591	response to cAMP	DUOX2	IDA		Human	PMID:15062544
Biological Process	GO:0009615	response to virus	DUOX2	IDA		Human	PMID:16111680
Biological Process	GO:0009611	response to wounding	duox	IMP	ZFIN:ZDB-MRPHLNO-091117-1	Zfish	PMID:19494811
Biological Process	GO:0042554	superoxide anion generation	DUOX2	IGI	UniProtKB:Q1HG43	Human	PMID:22814254
Biological Process	GO:0030878	thyroid gland development	Duox2	IMP	MGI:MGI:3712359	Mouse	PMID:17440044
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-230121-3	Zfish	PMID:31678421
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-230121-1	Zfish	PMID:31678421
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-230121-4	Zfish	PMID:31678421
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-230121-2	Zfish	PMID:31678421
Biological Process	GO:0030878	thyroid gland development	duox	IMP	ZFIN:ZDB-GENO-190722-9	Zfish	PMID:30700401
Biological Process	GO:0006590	thyroid hormone generation	duox	IMP	ZFIN:ZDB-GENO-230121-4	Zfish	PMID:31678421
Biological Process	GO:0006590	thyroid hormone generation	duox	IMP	ZFIN:ZDB-GENO-230121-1	Zfish	PMID:31678421
Biological Process	GO:0006590	thyroid hormone generation	duox	IMP	ZFIN:ZDB-GENO-230121-3	Zfish	PMID:31678421
Biological Process	GO:0006590	thyroid hormone generation	duox	IMP	ZFIN:ZDB-GENO-230121-2	Zfish	PMID:31678421
Biological Process	GO:0042403	thyroid hormone metabolic process	Duox2	IMP	MGI:MGI:3712359	Mouse	PMID:17440044

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern