Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DUOXA1
  • Mouse genes Duoxa1
  • Rat genes Duoxa1
  • Zfish genes duox2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Duoxa1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Duoxa1	IPI	MGI:MGI:2139422	Mouse	PMID:20233719
Cellular Component	GO:0005886	plasma membrane	Duoxa1	IDA		Mouse	PMID:20233719
Biological Process	GO:0042743	hydrogen peroxide metabolic process	Duoxa1	IGI	MGI:MGI:1914061	Mouse	PMID:23770197
Biological Process	GO:0010729	positive regulation of hydrogen peroxide biosynthetic process	DUOXA1	IMP		Human	PMID:22814254
Biological Process	GO:0045666	positive regulation of neuron differentiation	Duoxa1	IMP		Mouse	PMID:20233719
Biological Process	GO:0045666	positive regulation of neuron differentiation	Duoxa1	IDA		Mouse	PMID:20233719
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Duoxa1	IGI	MGI:MGI:2139422	Mouse	PMID:20233719
Biological Process	GO:0008104	protein localization	DUOXA1	IGI	UniProtKB:Q9NRD9	Human	PMID:19339556
Biological Process	GO:0008104	protein localization	DUOXA1	IGI	UniProtKB:Q9NRD8	Human	PMID:22814254
Biological Process	GO:0008104	protein localization	DUOXA1	IGI	UniProtKB:Q9NRD9	Human	PMID:22814254
Biological Process	GO:0050727	regulation of inflammatory response	Duoxa1	IGI	MGI:MGI:1914061	Mouse	PMID:23770197
Biological Process	GO:2000609	regulation of thyroid hormone generation	Duoxa1	IGI	MGI:MGI:1914061	Mouse	PMID:22301785
Biological Process	GO:0030878	thyroid gland development	duox2	IMP	ZFIN:ZDB-GENO-190116-7	Zfish	PMID:31678421

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern