Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Dusp1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes DUSP1
- Mouse genes Dusp1
- Rat genes Dusp1
- Zfish genes dusp1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dusp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019838	growth factor binding	Dusp1	IPI	RGD:3552	Rat	PMID:18929742\|RGD:10044027
Molecular Function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Dusp1	IMP		Mouse	MGI:MGI:79138\|PMID:8221888
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	Dusp1	IPI	UniProtKB:P63085	Mouse	MGI:MGI:79138\|PMID:8221888
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	Dusp1	IDA		Mouse	MGI:MGI:79138\|PMID:8221888
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:P27361	Human	PMID:10617468
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:P0CG47	Human	PMID:16286470
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:P28482	Human	PMID:16286470
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:Q13309	Human	PMID:16286470
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:P27361	Human	PMID:20347885
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:Q16539	Human	PMID:20347885
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:Q16539	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:P27361	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:Q16539	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	DUSP1	IPI	UniProtKB:Q16539	Human	PMID:27880917
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	Dusp1	IMP		Mouse	MGI:MGI:62859\|PMID:8355678
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	DUSP1	IDA		Human	PMID:1406996
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Dusp1	IMP		Mouse	MGI:MGI:62859\|PMID:8355678
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	DUSP1	IDA		Human	PMID:17498703
Molecular Function	GO:0008330	protein tyrosine/threonine phosphatase activity	Dusp1	IDA		Rat	PMID:12435803\|RGD:633811
Cellular Component	GO:0005737	cytoplasm	DUSP1	IDA		Human	PMID:7593328
Cellular Component	GO:0005634	nucleus	DUSP1	IDA		Human	PMID:7593328
Cellular Component	GO:0005634	nucleus	Dusp1	IDA		Rat	PMID:8883936\|RGD:2298690
Biological Process	GO:1990869	cellular response to chemokine	DUSP1	IMP		Human	PMID:22991462
Biological Process	GO:0032870	cellular response to hormone stimulus	Dusp1	IEP		Rat	PMID:15358679\|RGD:2298683
Biological Process	GO:0035556	intracellular signal transduction	Dusp1	IDA		Rat	PMID:11423551\|RGD:628467
Biological Process	GO:0043066	negative regulation of apoptotic process	Dusp1	IMP		Rat	PMID:15059639\|RGD:2298685
Biological Process	GO:0007162	negative regulation of cell adhesion	DUSP1	IMP		Human	PMID:22991462
Biological Process	GO:0008285	negative regulation of cell population proliferation	Dusp1	IMP		Mouse	MGI:MGI:62859\|PMID:8355678
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	Dusp1	IDA		Rat	PMID:10446064\|RGD:7771571
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Dusp1	IMP		Rat	PMID:17437549\|RGD:7771545
Biological Process	GO:0043407	negative regulation of MAP kinase activity	DUSP1	IDA		Human	PMID:7593328
Biological Process	GO:0043409	negative regulation of MAPK cascade	Dusp1	IMP		Mouse	MGI:MGI:79138\|PMID:8221888
Biological Process	GO:0090027	negative regulation of monocyte chemotaxis	DUSP1	IMP		Human	PMID:22991462
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	DUSP1	IMP		Human	PMID:22991462
Biological Process	GO:0070262	peptidyl-serine dephosphorylation	Dusp1	IMP		Mouse	MGI:MGI:62859\|PMID:8355678
Biological Process	GO:0035970	peptidyl-threonine dephosphorylation	Dusp1	IMP		Mouse	MGI:MGI:79138\|PMID:8221888
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	DUSP1	IDA		Human	PMID:1406996
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	Dusp1	IMP		Mouse	MGI:MGI:79138\|PMID:8221888
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	Dusp1	IMP		Mouse	MGI:MGI:62859\|PMID:8355678
Biological Process	GO:0043065	positive regulation of apoptotic process	Dusp1	IMP		Rat	PMID:9228085\|RGD:2298687
Biological Process	GO:0006470	protein dephosphorylation	Dusp1	IDA		Rat	PMID:12435803\|RGD:633811
Biological Process	GO:0051592	response to calcium ion	Dusp1	IEP		Rat	PMID:11423551\|RGD:628467
Biological Process	GO:0051591	response to cAMP	Dusp1	IEP		Rat	PMID:15358679\|RGD:2298683
Biological Process	GO:0032355	response to estradiol	Dusp1	IEP		Rat	PMID:8804359\|RGD:2298691
Biological Process	GO:0051384	response to glucocorticoid	Dusp1	IEP		Rat	PMID:17403137\|RGD:2298680
Biological Process	GO:0042542	response to hydrogen peroxide	Dusp1	IEP		Rat	PMID:7540516\|RGD:2298679
Biological Process	GO:0009416	response to light stimulus	Dusp1	IEP		Rat	PMID:15527789\|RGD:2298681
Biological Process	GO:0010033	response to organic substance	Dusp1	IEP		Rat	PMID:11027531\|RGD:2301725
Biological Process	GO:0032526	response to retinoic acid	Dusp1	IEP		Rat	PMID:15494319\|RGD:2298682
Biological Process	GO:0033574	response to testosterone	Dusp1	IEP		Rat	PMID:8804359\|RGD:2298691

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.