Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DUSP10
  • Mouse genes Dusp10
  • Rat genes Dusp10
  • Zfish genes dusp10
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dusp10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008432	JUN kinase binding	DUSP10	IDA		Human	PMID:10391943
Molecular Function	GO:0033549	MAP kinase phosphatase activity	DUSP10	IDA		Human	PMID:22375048
Molecular Function	GO:0033549	MAP kinase phosphatase activity	Dusp10	IDA		Mouse	MGI:MGI:5905244|PMID:25772234
Molecular Function	GO:0048273	mitogen-activated protein kinase p38 binding	DUSP10	IPI	UniProtKB:Q16539	Human	PMID:10391943
Molecular Function	GO:0016791	phosphatase activity	DUSP10	IDA		Human	PMID:16806267
Molecular Function	GO:0016791	phosphatase activity	DUSP10	IDA		Human	PMID:24531476
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:P45984	Human	PMID:16288922
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:P45984	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:P45983-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:P45984	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:Q53EP0-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:Q9BYR7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:P01112	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:P02489	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:Q14204	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:Q14957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:Q86V38	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:Q9UMX0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DUSP10	IPI	UniProtKB:Q9Y5Z0	Human	PMID:32814053
Molecular Function	GO:0008330	protein tyrosine/threonine phosphatase activity	DUSP10	IDA		Human	PMID:10391943
Cellular Component	GO:0005737	cytoplasm	DUSP10	IDA		Human	PMID:10391943
Cellular Component	GO:0005829	cytosol	DUSP10	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	DUSP10	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DUSP10	IDA		Human	PMID:10391943
Biological Process	GO:0016311	dephosphorylation	DUSP10	IDA		Human	PMID:24531476
Biological Process	GO:0010633	negative regulation of epithelial cell migration	Dusp10	IMP		Mouse	MGI:MGI:5905244|PMID:25772234
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Dusp10	IMP		Mouse	MGI:MGI:5905244|PMID:25772234
Biological Process	GO:1905042	negative regulation of epithelium regeneration	Dusp10	IDA		Mouse	MGI:MGI:5905244|PMID:25772234
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Dusp10	IMP		Mouse	MGI:MGI:5905244|PMID:25772234
Biological Process	GO:0046329	negative regulation of JNK cascade	DUSP10	IDA		Human	PMID:10391943
Biological Process	GO:0046329	negative regulation of JNK cascade	Dusp10	IMP	MGI:MGI:3052343	Mouse	PMID:15306813
Biological Process	GO:0043508	negative regulation of JUN kinase activity	DUSP10	IDA		Human	PMID:10391943
Biological Process	GO:0043508	negative regulation of JUN kinase activity	Dusp10	IMP	MGI:MGI:3052343	Mouse	PMID:15306813
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	Dusp10	IMP		Rat	PMID:19139271|RGD:7775012
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	DUSP10	IDA		Human	PMID:10391943
Biological Process	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	Dusp10	IDA		Mouse	PMID:23977283
Biological Process	GO:0060266	negative regulation of respiratory burst involved in inflammatory response	Dusp10	IMP	MGI:MGI:3052343	Mouse	PMID:19696743
Biological Process	GO:0032873	negative regulation of stress-activated MAPK cascade	Dusp10	IMP	MGI:MGI:3052343	Mouse	PMID:19696743
Biological Process	GO:0048709	oligodendrocyte differentiation	Dusp10	IMP		Mouse	PMID:19139271
Biological Process	GO:0035970	peptidyl-threonine dephosphorylation	DUSP10	IDA		Human	PMID:10391943
Biological Process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	DUSP10	IDA		Human	PMID:10391943
Biological Process	GO:0045591	positive regulation of regulatory T cell differentiation	DUSP10	IMP		Human	PMID:22387553
Biological Process	GO:0006470	protein dephosphorylation	Dusp10	IDA		Mouse	MGI:MGI:5905244|PMID:25772234
Biological Process	GO:0002819	regulation of adaptive immune response	Dusp10	IMP	MGI:MGI:3052343	Mouse	PMID:15306813
Biological Process	GO:0090335	regulation of brown fat cell differentiation	Dusp10	IDA		Mouse	PMID:23874687
Biological Process	GO:0045088	regulation of innate immune response	Dusp10	IMP	MGI:MGI:3052343	Mouse	PMID:15306813
Biological Process	GO:0032496	response to lipopolysaccharide	Dusp10	IMP	MGI:MGI:3052343	Mouse	PMID:19696743
Biological Process	GO:0010033	response to organic substance	Dusp10	IEP		Rat	PMID:11027531|RGD:2301725
Biological Process	GO:0051403	stress-activated MAPK cascade	Dusp10	IMP	MGI:MGI:3052343	Mouse	PMID:19696743

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern