Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DUSP22
  • Mouse genes Dusp22
  • Rat genes Dusp22
  • Zfish genes dusp22b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dusp22

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	DUSP22	IDA		Human	PMID:20018849
Molecular Function	GO:0005515	protein binding	Dusp22	IPI	UniProtKB:O14733	Mouse	PMID:12138158
Molecular Function	GO:1990782	protein tyrosine kinase binding	DUSP22	IPI	UniProtKB:P06239	Human	PMID:24714587
Molecular Function	GO:1990782	protein tyrosine kinase binding	Dusp22	IPI	UniProtKB:P06240	Mouse	MGI:MGI:5583944|PMID:24714587
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	DUSP22	IDA		Human	PMID:24714587
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Dusp22	IDA		Mouse	PMID:24714587
Cellular Component	GO:0005737	cytoplasm	DUSP22	IDA		Human	PMID:20018849
Cellular Component	GO:0031941	filamentous actin	DUSP22	IDA		Human	PMID:20018849
Cellular Component	GO:0061851	leading edge of lamellipodium	DUSP22	IDA		Human	PMID:20018849
Cellular Component	GO:0005886	plasma membrane	DUSP22	IDA		Human	PMID:24714587
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	DUSP22	IDA		Human	PMID:20018849
Biological Process	GO:0030336	negative regulation of cell migration	DUSP22	IMP		Human	PMID:20018849
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	DUSP22	IDA		Human	PMID:20018849
Biological Process	GO:1903996	negative regulation of non-membrane spanning protein tyrosine kinase activity	DUSP22	IMP		Human	PMID:20018849
Biological Process	GO:0050868	negative regulation of T cell activation	Dusp22	IMP		Mouse	PMID:24714587
Biological Process	GO:0002710	negative regulation of T cell mediated immunity	Dusp22	IMP		Mouse	PMID:24714587
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	Dusp22	IMP		Mouse	PMID:24714587
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	DUSP22	IMP		Human	PMID:16636663
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	DUSP22	IDA		Human	PMID:20018849
Biological Process	GO:0046330	positive regulation of JNK cascade	Dusp22	IDA		Mouse	PMID:12138158
Biological Process	GO:0042127	regulation of cell population proliferation	Dusp22	IMP		Mouse	PMID:12138158
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Dusp22	IMP		Mouse	PMID:12138158

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern