Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DUSP3
  • Mouse genes Dusp3
  • Rat genes Dusp3
  • Zfish genes dusp3a,dusp3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dusp3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008092	cytoskeletal protein binding	DUSP3	IPI	UniProtKB:P49023	Human	PMID:28759036
Molecular Function	GO:0033549	MAP kinase phosphatase activity	DUSP3	IMP		Human	PMID:16604064
Molecular Function	GO:0016791	phosphatase activity	DUSP3	IDA		Human	PMID:24531476
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	Dusp3	IDA		Mouse	PMID:18035061
Molecular Function	GO:0005515	protein binding	DUSP3	IPI	UniProtKB:P50221	Human	PMID:32296183
Molecular Function	GO:0019901	protein kinase binding	DUSP3	IDA		Human	PMID:22572157
Molecular Function	GO:1990782	protein tyrosine kinase binding	DUSP3	IPI	UniProtKB:Q05397	Human	PMID:28759036
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	DUSP3	IDA		Human	PMID:11863439
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	DUSP3	IMP		Human	PMID:28759036
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	DUSP3	IDA		Human	PMID:7876121
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	DUSP3	IMP		Human	PMID:7961745
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Dusp3	IDA		Mouse	PMID:11432789
Molecular Function	GO:0030971	receptor tyrosine kinase binding	DUSP3	IPI	UniProtKB:P00533	Human	PMID:28759036
Cellular Component	GO:0005829	cytosol	DUSP3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	DUSP3	IDA		Human	PMID:12447358
Cellular Component	GO:0005829	cytosol	DUSP3	IDA		Human	PMID:18505570
Cellular Component	GO:0001772	immunological synapse	DUSP3	IDA		Human	PMID:12447358
Cellular Component	GO:0005654	nucleoplasm	DUSP3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DUSP3	IDA		Human	PMID:16604064
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	DUSP3	IMP		Human	PMID:28759036
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Dusp3	IMP		Mouse	MGI:MGI:6101044|PMID:28759036
Biological Process	GO:0016311	dephosphorylation	DUSP3	IDA		Human	PMID:24531476
Biological Process	GO:0001701	in utero embryonic development	Dusp3	IDA		Rat	PMID:18035061|RGD:2317890
Biological Process	GO:0030336	negative regulation of cell migration	DUSP3	IMP		Human	PMID:28759036
Biological Process	GO:0050922	negative regulation of chemotaxis	DUSP3	IMP		Human	PMID:28759036
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Dusp3	IMP		Mouse	MGI:MGI:6101044|PMID:28759036
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	DUSP3	IDA		Human	PMID:11085983
Biological Process	GO:0046329	negative regulation of JNK cascade	DUSP3	IDA		Human	PMID:11085983
Biological Process	GO:0046329	negative regulation of JNK cascade	DUSP3	IMP		Human	PMID:19010898
Biological Process	GO:0043409	negative regulation of MAPK cascade	DUSP3	IMP		Human	PMID:16604064
Biological Process	GO:0050868	negative regulation of T cell activation	DUSP3	IDA		Human	PMID:12447358
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	DUSP3	IDA		Human	PMID:12447358
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	DUSP3	IDA		Human	PMID:11863439
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	DUSP3	IMP		Human	PMID:28759036
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	DUSP3	IDA		Human	PMID:7876121
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	Dusp3	IMP		Mouse	MGI:MGI:6101044|PMID:28759036
Biological Process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	Dusp3	IMP		Mouse	MGI:MGI:6101044|PMID:28759036
Biological Process	GO:0120183	positive regulation of focal adhesion disassembly	DUSP3	IMP		Human	PMID:28759036
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	DUSP3	IMP		Human	PMID:16604064
Biological Process	GO:0006470	protein dephosphorylation	Dusp3	IDA		Mouse	PMID:18035061
Biological Process	GO:0051893	regulation of focal adhesion assembly	DUSP3	IMP		Human	PMID:28759036
Biological Process	GO:0051893	regulation of focal adhesion assembly	Dusp3	IMP		Mouse	MGI:MGI:6101044|PMID:28759036

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern