Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DUSP4
  • Mouse genes Dusp4
  • Rat genes Dusp4
  • Zfish genes dusp4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dusp4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990439	MAP kinase serine/threonine phosphatase activity	DUSP4	IDA		Human	PMID:7535768
Molecular Function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Dusp4	IDA		Rat	PMID:7782322|RGD:633293
Molecular Function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	dusp4	IMP		Zfish	PMID:29275993
Molecular Function	GO:0016791	phosphatase activity	DUSP4	IDA		Human	PMID:24531476
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:P28482	Human	PMID:16038800
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:P45984	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:P28482	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:P28482	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:P28482	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:P45984	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q13077	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q86UR1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q8IV50-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q8N720	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q96N21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q96S90	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q9BRK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q9BUY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q9H8W4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DUSP4	IPI	UniProtKB:Q9H8Y8	Human	PMID:32296183
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	DUSP4	IDA		Human	PMID:7535768
Molecular Function	GO:0008330	protein tyrosine/threonine phosphatase activity	DUSP4	IDA		Human	PMID:7535768
Molecular Function	GO:0008330	protein tyrosine/threonine phosphatase activity	Dusp4	IDA		Rat	PMID:12435803|RGD:633811
Cellular Component	GO:0005654	nucleoplasm	DUSP4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DUSP4	IDA		Human	PMID:7535768
Biological Process	GO:0016311	dephosphorylation	DUSP4	IDA		Human	PMID:24531476
Biological Process	GO:0001706	endoderm formation	dusp4	IMP	ZFIN:ZDB-MRPHLNO-081229-8	Zfish	PMID:18719100
Biological Process	GO:0001706	endoderm formation	dusp4	IMP	ZFIN:ZDB-MRPHLNO-081229-7	Zfish	PMID:18719100
Biological Process	GO:0001714	endodermal cell fate specification	dusp4	IMP	ZFIN:ZDB-MRPHLNO-081229-7	Zfish	PMID:18719100
Biological Process	GO:0001714	endodermal cell fate specification	dusp4	IMP	ZFIN:ZDB-MRPHLNO-081229-8	Zfish	PMID:18719100
Biological Process	GO:1903225	negative regulation of endodermal cell differentiation	dusp4	IMP	ZFIN:ZDB-MRPHLNO-081229-7	Zfish	PMID:29275993
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	DUSP4	IMP		Human	PMID:7535768
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	dusp4	IMP		Zfish	PMID:29275993
Biological Process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	dusp4	IMP		Zfish	PMID:29275993
Biological Process	GO:0006470	protein dephosphorylation	Dusp4	IDA		Rat	PMID:12435803|RGD:633811

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern