Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DVL2
  • Mouse genes Dvl2
  • Rat genes
  • Zfish genes dvl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dvl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	DVL2	IPI	UniProtKB:O75084	Human	PMID:19388021
Molecular Function	GO:0005109	frizzled binding	DVL2	IPI	UniProtKB:Q14332	Human	PMID:19388021
Molecular Function	GO:0005109	frizzled binding	DVL2	IPI	UniProtKB:Q9NPG1	Human	PMID:19388021
Molecular Function	GO:0005109	frizzled binding	DVL2	IPI	UniProtKB:Q9ULV1	Human	PMID:19388021
Molecular Function	GO:0005109	frizzled binding	DVL2	IPI	UniProtKB:Q9UP38	Human	PMID:19388021
Molecular Function	GO:0005109	frizzled binding	Dvl2	IPI	UniProtKB:Q9ULV1	Mouse	MGI:MGI:4944157|PMID:20802536
Molecular Function	GO:0042802	identical protein binding	DVL2	IPI	UniProtKB:O14641	Human	PMID:16189514
Molecular Function	GO:0042802	identical protein binding	DVL2	IPI	UniProtKB:O14641	Human	PMID:27107012
Molecular Function	GO:0042802	identical protein binding	Dvl2	IPI	UniProtKB:Q60838	Mouse	MGI:MGI:5285137|PMID:21189423
Molecular Function	GO:0042802	identical protein binding	Dvl2	IPI	UniProtKB:Q60838	Mouse	MGI:MGI:5917236|PMID:17529994
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:O75369	Human	PMID:10644691
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P35813	Human	PMID:10644691
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P63172	Human	PMID:10644691
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P29066	Human	PMID:11742073
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P04637	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P49674	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P49910	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q96CG3	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q9NYF0	Human	PMID:16446366
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P04637	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q14134	Human	PMID:19249679
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:A2A5Z6	Human	PMID:19379695
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q9Z101	Human	PMID:19379695
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q9NZC7	Human	PMID:19465938
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q5S007	Human	PMID:19625296
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P25054	Human	PMID:20224554
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q5R2U3	Human	PMID:20412773
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q9GZV5	Human	PMID:20412773
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q155Q3	Human	PMID:20823832
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:O15169	Human	PMID:21245303
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q9NYF0	Human	PMID:21262972
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q96RL1	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P53350	Human	PMID:22609948
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q9NYF0	Human	PMID:22610794
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:O15169	Human	PMID:22773187
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P57078	Human	PMID:23371553
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P49674	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q96BN8	Human	PMID:23708998
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q9UHG0	Human	PMID:25557784
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P25054	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P04637	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q08117-2	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q96CG3	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q96RL1	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q5S007	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P04637	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P49674	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P49910	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:Q96RL1	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P49674	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P53350	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P01112	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DVL2	IPI	UniProtKB:P28329-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q155Q3	Mouse	MGI:MGI:5285137|PMID:21189423
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:P48730|UniProtKB:P49674|UniProtKB:P53350	Mouse	MGI:MGI:5508708|PMID:22609948
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q9Y4D1-1	Mouse	MGI:MGI:6093197|PMID:18162551
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q8R4A3|UniProtKB:Q91ZD4	Mouse	MGI:MGI:4359544|PMID:19701191
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:P84092	Mouse	MGI:MGI:5918172|PMID:20947020
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q80Y86	Mouse	MGI:MGI:5641772|PMID:25823377
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q60610	Mouse	MGI:MGI:5466648|PMID:23109420
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:P98078	Mouse	MGI:MGI:2664441|PMID:12805222
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q80Z96|UniProtKB:Q91ZD4	Mouse	MGI:MGI:3525406|PMID:15456783
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q61062	Mouse	MGI:MGI:4946155|PMID:21092292
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q13009	Mouse	MGI:MGI:5466648|PMID:23109420
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q69ZU8-1	Mouse	MGI:MGI:6092552|PMID:17032765
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q9NZC7	Mouse	MGI:MGI:5700281|PMID:25678599
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q8K120	Mouse	MGI:MGI:5295911|PMID:21880741
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q9D1E5	Mouse	MGI:MGI:6303730|PMID:31073040
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	UniProtKB:Q8R4A3	Mouse	MGI:MGI:5437409|PMID:21718540
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	PR:Q3TP92	Mouse	PMID:23469192
Molecular Function	GO:0005515	protein binding	Dvl2	IPI	PR:P05480	Mouse	PMID:19920076
Molecular Function	GO:0005515	protein binding	dvl2	IPI	UniProtKB:Q6IVV9	Zfish	PMID:19395640
Molecular Function	GO:0019904	protein domain specific binding	Dvl2	IPI	PR:O35625	Mouse	PMID:15579909
Molecular Function	GO:0019901	protein kinase binding	Dvl2	IPI	UniProtKB:P49674|UniProtKB:Q9JMK2	Mouse	MGI:MGI:3707948|PMID:17244647
Molecular Function	GO:0043621	protein self-association	Dvl2	IDA		Mouse	MGI:MGI:5285137|PMID:21189423
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Dvl2	IDA		Mouse	MGI:MGI:5466648|PMID:23109420
Molecular Function	GO:0031267	small GTPase binding	Dvl2	IPI	UniProtKB:P63000	Mouse	MGI:MGI:5466648|PMID:23109420
Cellular Component	GO:0016235	aggresome	DVL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045177	apical part of cell	Dvl2	IDA		Mouse	PMID:19300477
Cellular Component	GO:0005938	cell cortex	dvl2	IDA		Zfish	PMID:21074723
Cellular Component	GO:0030136	clathrin-coated vesicle	Dvl2	IDA		Mouse	PMID:17005174
Cellular Component	GO:0005737	cytoplasm	DVL2	IDA		Human	PMID:23209302
Cellular Component	GO:0005737	cytoplasm	DVL2	IDA		Human	PMID:9192851
Cellular Component	GO:0005737	cytoplasm	Dvl2	IDA		Mouse	MGI:MGI:3707948|PMID:17244647
Cellular Component	GO:0005737	cytoplasm	Dvl2	IDA		Mouse	MGI:MGI:4365507|PMID:19465938
Cellular Component	GO:0005737	cytoplasm	Dvl2	IDA		Mouse	PMID:23580654
Cellular Component	GO:0005737	cytoplasm	Dvl2	IDA		Mouse	PMID:17606995
Cellular Component	GO:0031410	cytoplasmic vesicle	DVL2	IDA		Human	PMID:23209302
Cellular Component	GO:0005829	cytosol	Dvl2	IDA		Mouse	MGI:MGI:5466648|PMID:23109420
Cellular Component	GO:0005829	cytosol	Dvl2	IDA		Mouse	MGI:MGI:5285137|PMID:21189423
Cellular Component	GO:0016328	lateral plasma membrane	Dvl2	IDA		Mouse	PMID:23533177
Cellular Component	GO:0016604	nuclear body	DVL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	DVL2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Dvl2	IMP		Mouse	MGI:MGI:4365507|PMID:19465938
Cellular Component	GO:0005886	plasma membrane	Dvl2	IDA		Mouse	MGI:MGI:4887519|PMID:20534871
Cellular Component	GO:0005886	plasma membrane	Dvl2	IDA		Mouse	PMID:17005174
Cellular Component	GO:0005886	plasma membrane	Dvl2	IGI	MGI:MGI:98956	Mouse	PMID:17606995
Cellular Component	GO:0005886	plasma membrane	Dvl2	IDA		Mouse	PMID:16116426
Cellular Component	GO:0005886	plasma membrane	Dvl2	IDA		Mouse	PMID:16571627
Cellular Component	GO:0005819	spindle	dvl2	IDA		Zfish	PMID:21074723
Biological Process	GO:0060070	canonical Wnt signaling pathway	DVL2	IDA		Human	PMID:17593335
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dvl2	IMP		Mouse	MGI:MGI:5700301|PMID:18093802
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dvl2	IMP		Mouse	MGI:MGI:5285137|PMID:21189423
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dvl2	IGI	MGI:MGI:1351660	Mouse	PMID:17606995
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dvl2	IDA		Mouse	PMID:18606138
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dvl2	IMP	MGI:MGI:2429760	Mouse	PMID:19008950
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dvl2	IDA		Mouse	PMID:8887313
Biological Process	GO:0060070	canonical Wnt signaling pathway	Dvl2	IGI	MGI:MGI:98956	Mouse	PMID:10409711
Biological Process	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation	DVL2	IDA		Human	PMID:18787224
Biological Process	GO:0021535	cell migration in hindbrain	dvl2	IMP	ZFIN:ZDB-MRPHLNO-060724-1	Zfish	PMID:17392791
Biological Process	GO:0090103	cochlea morphogenesis	Dvl2	IGI	MGI:MGI:94941	Mouse	PMID:16116426
Biological Process	GO:0090103	cochlea morphogenesis	Dvl2	IGI	MGI:MGI:108100	Mouse	PMID:19008950
Biological Process	GO:0060026	convergent extension	dvl2	IMP		Zfish	ZFIN:ZDB-PUB-130605-16
Biological Process	GO:0060028	convergent extension involved in axis elongation	dvl2	IGI	ZFIN:ZDB-MRPHLNO-060724-1,ZFIN:ZDB-MRPHLNO-060724-2	Zfish	PMID:16547521
Biological Process	GO:0060028	convergent extension involved in axis elongation	dvl2	IGI	ZFIN:ZDB-GENE-041114-205,ZFIN:ZDB-MRPHLNO-060724-1	Zfish	PMID:16547521
Biological Process	GO:0022007	convergent extension involved in neural plate elongation	Dvl2	IMP	MGI:MGI:2429760	Mouse	PMID:16571627
Biological Process	GO:0022007	convergent extension involved in neural plate elongation	Dvl2	IGI	MGI:MGI:2135272	Mouse	PMID:16571627
Biological Process	GO:0022007	convergent extension involved in neural plate elongation	Dvl2	IGI	MGI:MGI:94941	Mouse	PMID:16571627
Biological Process	GO:0060029	convergent extension involved in organogenesis	Dvl2	IGI	MGI:MGI:94941	Mouse	PMID:16116426
Biological Process	GO:0060322	head development	dvl2	IGI	ZFIN:ZDB-MRPHLNO-150213-2,ZFIN:ZDB-MRPHLNO-150213-4	Zfish	PMID:25439725
Biological Process	GO:0060322	head development	dvl2	IMP	ZFIN:ZDB-MRPHLNO-150213-2	Zfish	PMID:25439725
Biological Process	GO:0060322	head development	dvl2	IGI	ZFIN:ZDB-MRPHLNO-150213-2,ZFIN:ZDB-MRPHLNO-150213-3	Zfish	PMID:25439725
Biological Process	GO:0060322	head development	dvl2	IGI	ZFIN:ZDB-MRPHLNO-150213-1,ZFIN:ZDB-MRPHLNO-150213-2	Zfish	PMID:25439725
Biological Process	GO:0007507	heart development	Dvl2	IMP	MGI:MGI:2429760	Mouse	PMID:12464179
Biological Process	GO:0007507	heart development	Dvl2	IMP	MGI:MGI:2429760	Mouse	PMID:12421720
Biological Process	GO:0001947	heart looping	Dvl2	IGI	UniProtKB:P51141	Mouse	MGI:MGI:5439040|PMID:22841628
Biological Process	GO:0003007	heart morphogenesis	Dvl2	IGI	MGI:MGI:108100	Mouse	PMID:19008950
Biological Process	GO:0001843	neural tube closure	Dvl2	IMP	MGI:MGI:2429760	Mouse	PMID:12421720
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	DVL2	IMP		Human	PMID:19137009
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	dvl2	IMP		Zfish	ZFIN:ZDB-PUB-130605-16
Biological Process	GO:0003151	outflow tract morphogenesis	Dvl2	IMP		Mouse	MGI:MGI:2446944|PMID:12464179
Biological Process	GO:0003151	outflow tract morphogenesis	Dvl2	IGI	UniProtKB:P51141	Mouse	MGI:MGI:5439040|PMID:22841628
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Dvl2	IGI	MGI:MGI:94941	Mouse	PMID:16571627
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Dvl2	IMP	MGI:MGI:2429760	Mouse	PMID:16571627
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Dvl2	IGI	MGI:MGI:2135272	Mouse	PMID:16571627
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	DVL2	IDA		Human	PMID:17593335
Biological Process	GO:0043547	positive regulation of GTPase activity	Dvl2	IDA		Mouse	MGI:MGI:5466648|PMID:23109420
Biological Process	GO:0043507	positive regulation of JUN kinase activity	DVL2	IDA		Human	PMID:17593335
Biological Process	GO:0043507	positive regulation of JUN kinase activity	DVL2	IMP		Human	PMID:19137009
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Dvl2	IDA		Mouse	MGI:MGI:4835155|PMID:10829020
Biological Process	GO:0001934	positive regulation of protein phosphorylation	DVL2	IMP		Human	PMID:20137080
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Dvl2	IGI	MGI:MGI:98956	Mouse	PMID:19920076
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DVL2	IDA		Human	PMID:12805222
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	DVL2	IDA		Human	PMID:17593335
Biological Process	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway	dvl2	IMP	ZFIN:ZDB-GENO-200527-2	Zfish	PMID:30080849
Biological Process	GO:0036342	post-anal tail morphogenesis	dvl2	IGI	ZFIN:ZDB-MRPHLNO-060724-1,ZFIN:ZDB-MRPHLNO-060724-2,ZFIN:ZDB-MRPHLNO-060818-7	Zfish	PMID:21610036
Biological Process	GO:0036342	post-anal tail morphogenesis	dvl2	IGI	ZFIN:ZDB-GENO-100601-3,ZFIN:ZDB-MRPHLNO-060724-1,ZFIN:ZDB-MRPHLNO-060724-2	Zfish	PMID:21610036
Biological Process	GO:0036342	post-anal tail morphogenesis	dvl2	IGI	ZFIN:ZDB-MRPHLNO-060724-1,ZFIN:ZDB-MRPHLNO-060724-2,ZFIN:ZDB-MRPHLNO-060815-1	Zfish	PMID:21610036
Biological Process	GO:0036342	post-anal tail morphogenesis	dvl2	IGI	ZFIN:ZDB-MRPHLNO-060724-1,ZFIN:ZDB-MRPHLNO-060724-2	Zfish	PMID:21610036
Biological Process	GO:0008104	protein localization	Dvl2	IDA		Mouse	PMID:17606995
Biological Process	GO:0006355	regulation of DNA-templated transcription	DVL2	IDA		Human	PMID:11742073
Biological Process	GO:0007379	segment specification	Dvl2	IMP	MGI:MGI:2429760	Mouse	PMID:12421720
Biological Process	GO:0035282	segmentation	Dvl2	IGI	UniProtKB:P51140	Mouse	MGI:MGI:82989|PMID:8887313
Biological Process	GO:0016055	Wnt signaling pathway	Dvl2	IMP		Mouse	PMID:25190059
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	DVL2	IDA		Human	PMID:12805222
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	Dvl2	IGI	MGI:MGI:94941	Mouse	PMID:16116426

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern