Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DYRK2
  • Mouse genes Dyrk2
  • Rat genes Dyrk2
  • Zfish genes dyrk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dyrk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	DYRK2	IDA		Human	PMID:11311121
Molecular Function	GO:0000287	magnesium ion binding	DYRK2	IDA		Human	PMID:9748265
Molecular Function	GO:0030145	manganese ion binding	DYRK2	IDA		Human	PMID:9748265
Molecular Function	GO:0005515	protein binding	DYRK2	IPI	UniProtKB:Q9NR20	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	DYRK2	IPI	UniProtKB:O43379	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DYRK2	IPI	UniProtKB:P23497	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DYRK2	IPI	UniProtKB:Q13422	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DYRK2	IPI	UniProtKB:Q96C00	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DYRK2	IPI	UniProtKB:Q9BQD3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DYRK2	IPI	UniProtKB:Q9BRK4	Human	PMID:25416956
Molecular Function	GO:0004674	protein serine/threonine kinase activity	DYRK2	IDA		Human	PMID:11311121
Molecular Function	GO:0004713	protein tyrosine kinase activity	DYRK2	IDA		Human	PMID:9748265
Cellular Component	GO:0005737	cytoplasm	DYRK2	IDA		Human	PMID:17349958
Cellular Component	GO:0005737	cytoplasm	DYRK2	IDA		Human	PMID:18455992
Cellular Component	GO:0005829	cytosol	DYRK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	DYRK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DYRK2	IDA		Human	PMID:17349958
Cellular Component	GO:1990904	ribonucleoprotein complex	Dyrk2	IDA		Mouse	PMID:21709260
Cellular Component	GO:0000151	ubiquitin ligase complex	DYRK2	IDA		Human	PMID:19287380
Biological Process	GO:0006974	DNA damage response	DYRK2	IEP		Human	PMID:19965871
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	DYRK2	IDA		Human	PMID:17349958
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	DYRK2	IMP		Human	PMID:16511445
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	DYRK2	IDA		Human	PMID:11311121
Biological Process	GO:0006468	protein phosphorylation	DYRK2	IDA		Human	PMID:11311121
Biological Process	GO:0007224	smoothened signaling pathway	DYRK2	IMP		Human	PMID:18455992

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern