Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes E2F4
  • Mouse genes E2f4
  • Rat genes E2f4
  • Zfish genes e2f4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set E2f4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	E2f4	IDA		Mouse	PMID:22780989
Molecular Function	GO:0003677	DNA binding	E2F4	IMP		Human	PMID:11418595
Molecular Function	GO:0003677	DNA binding	E2f4	IDA		Mouse	PMID:15574595
Molecular Function	GO:0003677	DNA binding	E2f4	IDA		Mouse	PMID:10779331
Molecular Function	GO:0001216	DNA-binding transcription activator activity	E2F4	IDA		Human	PMID:17062573
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	E2F4	IDA		Human	PMID:11418595
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2F4	IDA		Human	PMID:11418595
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2f4	IDA		Mouse	PMID:15574595
Molecular Function	GO:1990841	promoter-specific chromatin binding	E2F4	IDA		Human	PMID:25100735
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q9Y4A5	Human	PMID:11418595
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:P51610	Human	PMID:14532282
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:P03129	Human	PMID:16061792
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:P06400	Human	PMID:16360038
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q14186	Human	PMID:16360038
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q14188	Human	PMID:16360038
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q5H9I0	Human	PMID:17062573
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q5TKA1	Human	PMID:17159899
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q08999	Human	PMID:17531812
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q5TKA1	Human	PMID:17531812
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q08999	Human	PMID:20133863
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:P29590	Human	PMID:22002537
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q08999	Human	PMID:22002537
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:P03129	Human	PMID:22810586
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q14186	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q14186	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q13526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q14186	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q14188-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	E2F4	IPI	UniProtKB:Q92993	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	E2f4	IPI	PR:Q64701	Mouse	PMID:7797074
Molecular Function	GO:0005515	protein binding	E2f4	IPI	PR:Q08639	Mouse	PMID:15448153
Molecular Function	GO:0019904	protein domain specific binding	E2F4	IPI	UniProtKB:P28749	Human	PMID:16360038
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	E2F4	IDA		Human	PMID:10488129
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	E2f4	IDA		Mouse	PMID:11004506
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	E2F4	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	E2F4	IDA		Human	PMID:21454377
Cellular Component	GO:0000785	chromatin	E2f4	IDA		Mouse	MGI:MGI:2178490|PMID:12007404
Cellular Component	GO:0005737	cytoplasm	E2F4	IDA		Human	PMID:17062573
Cellular Component	GO:0005654	nucleoplasm	E2F4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	E2f4	IDA		Mouse	PMID:15574595
Cellular Component	GO:0005634	nucleus	E2f4	IDA		Mouse	PMID:10779331
Cellular Component	GO:0005634	nucleus	E2f4	IDA		Mouse	PMID:17383628
Biological Process	GO:0009887	animal organ morphogenesis	E2f4	IMP	MGI:MGI:1888951	Mouse	PMID:10983977
Biological Process	GO:0009887	animal organ morphogenesis	E2f4	IMP	MGI:MGI:1888952	Mouse	PMID:10983976
Biological Process	GO:0008015	blood circulation	E2f4	IMP	MGI:MGI:1888951	Mouse	PMID:10983977
Biological Process	GO:0006884	cell volume homeostasis	E2f4	IMP	MGI:MGI:1888952	Mouse	PMID:10983976
Biological Process	GO:0060271	cilium assembly	E2f4	IMP	MGI:MGI:1888952	Mouse	PMID:17383628
Biological Process	GO:0002064	epithelial cell development	E2f4	IMP	MGI:MGI:1888952	Mouse	PMID:17383628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2F4	IDA		Human	PMID:11418595
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2f4	IGI	MGI:MGI:101934	Mouse	PMID:7797074
Biological Process	GO:0042127	regulation of cell population proliferation	E2f4	IDA		Mouse	PMID:10779331
Biological Process	GO:0008361	regulation of cell size	E2f4	IMP	MGI:MGI:1888952	Mouse	PMID:10983976
Biological Process	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	E2f4	IGI	MGI:MGI:1354159	Mouse	PMID:15574595
Biological Process	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	E2f4	IDA		Mouse	PMID:11004506

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern