Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes E2F6
  • Mouse genes E2f6
  • Rat genes E2f6
  • Zfish genes e2f6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set E2f6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	E2f6	IDA		Mouse	PMID:15574595
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2f6	IDA		Mouse	PMID:15574595
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	E2F6	IDA		Human	PMID:9501179
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	E2f6	IDA		Mouse	MGI:MGI:3814987|PMID:18667754
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14186	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14188	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q5H9I0	Human	PMID:17062573
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14186	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14188	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14186	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:P60409	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14186	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14188	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:P61244	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14186	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14188-5	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:P61244	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14186	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14188	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14186	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14188	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14186	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	E2F6	IPI	UniProtKB:Q14188-5	Human	PMID:32296183
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	E2F6	IDA		Human	PMID:9501179
Molecular Function	GO:0043565	sequence-specific DNA binding	E2f6	IDA		Mouse	MGI:MGI:3814987|PMID:18667754
Cellular Component	GO:0071339	MLL1 complex	E2F6	IDA		Human	PMID:15960975
Cellular Component	GO:0005654	nucleoplasm	E2F6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	E2F6	IDA		Human	PMID:17001316
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	E2F6	IDA		Human	PMID:9501179
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	E2F6	IDA		Human	PMID:9501179
Biological Process	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	E2f6	IGI	MGI:MGI:103012	Mouse	PMID:15574595

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern